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B2ZGJ1

- CLAT_DANRE

UniProt

B2ZGJ1 - CLAT_DANRE

Protein

Choline O-acetyltransferase

Gene

chat

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.1 Publication

    Catalytic activityi

    Acetyl-CoA + choline = CoA + O-acetylcholine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei329 – 3291Proton acceptorBy similarity
    Binding sitei445 – 4451Coenzyme ABy similarity
    Binding sitei545 – 5451Coenzyme ABy similarity

    GO - Molecular functioni

    1. choline O-acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. locomotory behavior Source: UniProtKB
    2. neurotransmitter biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Neurotransmitter biosynthesis

    Enzyme and pathway databases

    ReactomeiREACT_174660. Synthesis of PC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Choline O-acetyltransferase (EC:2.3.1.6)
    Short name:
    CHOACTase
    Short name:
    ChAT
    Short name:
    Choline acetylase
    Gene namesi
    Name:chat
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 13

    Organism-specific databases

    ZFINiZDB-GENE-080102-2. chata.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 637637Choline O-acetyltransferasePRO_0000351550Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiB2ZGJ1.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000025508.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni407 – 41913Coenzyme A bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG70127.
    GeneTreeiENSGT00740000115446.
    HOGENOMiHOG000233845.
    HOVERGENiHBG107717.
    KOiK00623.
    OMAiHVIVACC.
    OrthoDBiEOG7WHH90.
    PhylomeDBiB2ZGJ1.
    TreeFamiTF313836.

    Family and domain databases

    InterProiIPR000542. Carn_acyl_trans.
    [Graphical view]
    PANTHERiPTHR22589. PTHR22589. 1 hit.
    PfamiPF00755. Carn_acyltransf. 1 hit.
    [Graphical view]
    PROSITEiPS00439. ACYLTRANSF_C_1. 1 hit.
    PS00440. ACYLTRANSF_C_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2ZGJ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVSKREQSK DTGDPCALPK LPIPPLKQTL DMYLTCMGHL VPEDQFRKTK    50
    AVVEKFGAPG GVGETLQKKL LERSEQKANW VYDYWLEDMY LNNRLALPVN 100
    SSPVMVFHKQ NFKGQSDVLR FAANLISGVL EYKALIDGRA LPVEHARGQL 150
    AGTPLCMDQY NKVFTSYRLP GTKTDTLVAQ KSTVMPEPEH IIVACKNQFF 200
    VLDVMVNFRR LNEKDLYTQL ERIRKMADIE EERQPPIGLL TSDGRTQWAE 250
    ARNILIKDST NRDSLDMIER CLCLVCLDEE TATELNDSNR ALLMLHGGGT 300
    DKNGGNRWYD KPMQFVIGAD GCCGVVCEHS PFEGIVLVQC SEYLLRYMRG 350
    SPSKLVRAAS MSELPAPRRL RWKCSPDIQT FLSASADRLQ KLVKNLDMNV 400
    HKFTGYGKEF IKRQKMSPDA YVQVALQFTF YRCHGRLVPT YESASIRRFQ 450
    EGRVDNIRSS TPEALAFVKA MASGSKITDA EKMELLWTAI KAQTNYTILA 500
    ITGMAIDNHL LGLREIAKEL KLEKPELFSD TTYATSIHFT LSTSQVPTTE 550
    EMFCCYGPVV PNGYGACYNP QTDHILFCVS SFRECAETSS DLFVKTLEGC 600
    LKEMQDLCRK CNTEVKPADS TQRMEGNPKV MKNGSKS 637
    Length:637
    Mass (Da):71,840
    Last modified:July 1, 2008 - v1
    Checksum:i2379C23ADABC755A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU660883 mRNA. Translation: ACD40042.1.
    RefSeqiNP_001124191.1. NM_001130719.1.
    XP_005156786.1. XM_005156729.1.
    UniGeneiDr.117574.

    Genome annotation databases

    EnsembliENSDART00000024225; ENSDARP00000025508; ENSDARG00000015854.
    ENSDART00000150228; ENSDARP00000125038; ENSDARG00000015854.
    GeneIDi100170938.
    KEGGidre:100170938.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU660883 mRNA. Translation: ACD40042.1 .
    RefSeqi NP_001124191.1. NM_001130719.1.
    XP_005156786.1. XM_005156729.1.
    UniGenei Dr.117574.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000025508.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000024225 ; ENSDARP00000025508 ; ENSDARG00000015854 .
    ENSDART00000150228 ; ENSDARP00000125038 ; ENSDARG00000015854 .
    GeneIDi 100170938.
    KEGGi dre:100170938.

    Organism-specific databases

    CTDi 100170938.
    ZFINi ZDB-GENE-080102-2. chata.

    Phylogenomic databases

    eggNOGi NOG70127.
    GeneTreei ENSGT00740000115446.
    HOGENOMi HOG000233845.
    HOVERGENi HBG107717.
    KOi K00623.
    OMAi HVIVACC.
    OrthoDBi EOG7WHH90.
    PhylomeDBi B2ZGJ1.
    TreeFami TF313836.

    Enzyme and pathway databases

    Reactomei REACT_174660. Synthesis of PC.

    Miscellaneous databases

    NextBioi 20795505.
    PROi B2ZGJ1.

    Gene expression databases

    Bgeei B2ZGJ1.

    Family and domain databases

    InterProi IPR000542. Carn_acyl_trans.
    [Graphical view ]
    PANTHERi PTHR22589. PTHR22589. 1 hit.
    Pfami PF00755. Carn_acyltransf. 1 hit.
    [Graphical view ]
    PROSITEi PS00439. ACYLTRANSF_C_1. 1 hit.
    PS00440. ACYLTRANSF_C_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Function of neuromuscular synapses in the zebrafish choline-acetyltransferase mutant bajan."
      Wang M., Wen H., Brehm P.
      J. Neurophysiol. 100:1995-2004(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.

    Entry informationi

    Entry nameiCLAT_DANRE
    AccessioniPrimary (citable) accession number: B2ZGJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 14, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3