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B2ZGJ1 (CLAT_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Choline O-acetyltransferase

Short name=CHOACTase
Short name=ChAT
Short name=Choline acetylase
EC=2.3.1.6
Gene names
Name:chat
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length637 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Ref.1

Catalytic activity

Acetyl-CoA + choline = CoA + O-acetylcholine.

Sequence similarities

Belongs to the carnitine/choline acetyltransferase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 637637Choline O-acetyltransferase
PRO_0000351550

Regions

Region407 – 41913Coenzyme A binding By similarity

Sites

Active site3291Proton acceptor By similarity
Binding site4451Coenzyme A By similarity
Binding site5451Coenzyme A By similarity

Sequences

Sequence LengthMass (Da)Tools
B2ZGJ1 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 2379C23ADABC755A

FASTA63771,840
        10         20         30         40         50         60 
MPVSKREQSK DTGDPCALPK LPIPPLKQTL DMYLTCMGHL VPEDQFRKTK AVVEKFGAPG 

        70         80         90        100        110        120 
GVGETLQKKL LERSEQKANW VYDYWLEDMY LNNRLALPVN SSPVMVFHKQ NFKGQSDVLR 

       130        140        150        160        170        180 
FAANLISGVL EYKALIDGRA LPVEHARGQL AGTPLCMDQY NKVFTSYRLP GTKTDTLVAQ 

       190        200        210        220        230        240 
KSTVMPEPEH IIVACKNQFF VLDVMVNFRR LNEKDLYTQL ERIRKMADIE EERQPPIGLL 

       250        260        270        280        290        300 
TSDGRTQWAE ARNILIKDST NRDSLDMIER CLCLVCLDEE TATELNDSNR ALLMLHGGGT 

       310        320        330        340        350        360 
DKNGGNRWYD KPMQFVIGAD GCCGVVCEHS PFEGIVLVQC SEYLLRYMRG SPSKLVRAAS 

       370        380        390        400        410        420 
MSELPAPRRL RWKCSPDIQT FLSASADRLQ KLVKNLDMNV HKFTGYGKEF IKRQKMSPDA 

       430        440        450        460        470        480 
YVQVALQFTF YRCHGRLVPT YESASIRRFQ EGRVDNIRSS TPEALAFVKA MASGSKITDA 

       490        500        510        520        530        540 
EKMELLWTAI KAQTNYTILA ITGMAIDNHL LGLREIAKEL KLEKPELFSD TTYATSIHFT 

       550        560        570        580        590        600 
LSTSQVPTTE EMFCCYGPVV PNGYGACYNP QTDHILFCVS SFRECAETSS DLFVKTLEGC 

       610        620        630 
LKEMQDLCRK CNTEVKPADS TQRMEGNPKV MKNGSKS 

« Hide

References

[1]"Function of neuromuscular synapses in the zebrafish choline-acetyltransferase mutant bajan."
Wang M., Wen H., Brehm P.
J. Neurophysiol. 100:1995-2004(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EU660883 mRNA. Translation: ACD40042.1.
RefSeqNP_001124191.1. NM_001130719.1.
XP_005156786.1. XM_005156729.1.
UniGeneDr.117574.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000025508.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000024225; ENSDARP00000025508; ENSDARG00000015854.
ENSDART00000150228; ENSDARP00000125038; ENSDARG00000015854.
GeneID100170938.
KEGGdre:100170938.

Organism-specific databases

CTD1103.
ZFINZDB-GENE-080102-2. chat.

Phylogenomic databases

eggNOGNOG70127.
GeneTreeENSGT00740000115446.
HOGENOMHOG000233845.
HOVERGENHBG107717.
KOK00623.
OMAATYLQCM.
OrthoDBEOG7WHH90.
TreeFamTF313836.

Gene expression databases

BgeeB2ZGJ1.

Family and domain databases

InterProIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERPTHR22589. PTHR22589. 1 hit.
PfamPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEPS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20795505.
PROB2ZGJ1.

Entry information

Entry nameCLAT_DANRE
AccessionPrimary (citable) accession number: B2ZGJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: July 1, 2008
Last modified: February 19, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families