SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B2ZGJ1

- CLAT_DANRE

UniProt

B2ZGJ1 - CLAT_DANRE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Choline O-acetyltransferase

Gene
chat
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.1 Publication

Catalytic activityi

Acetyl-CoA + choline = CoA + O-acetylcholine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei329 – 3291Proton acceptor By similarity
Binding sitei445 – 4451Coenzyme A By similarity
Binding sitei545 – 5451Coenzyme A By similarity

GO - Molecular functioni

  1. choline O-acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. locomotory behavior Source: UniProtKB
  2. neurotransmitter biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Neurotransmitter biosynthesis

Enzyme and pathway databases

ReactomeiREACT_174660. Synthesis of PC.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline O-acetyltransferase (EC:2.3.1.6)
Short name:
CHOACTase
Short name:
ChAT
Short name:
Choline acetylase
Gene namesi
Name:chat
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-080102-2. chata.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 637637Choline O-acetyltransferasePRO_0000351550Add
BLAST

Expressioni

Gene expression databases

BgeeiB2ZGJ1.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000025508.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni407 – 41913Coenzyme A binding By similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG70127.
GeneTreeiENSGT00740000115446.
HOGENOMiHOG000233845.
HOVERGENiHBG107717.
KOiK00623.
OMAiHVIVACC.
OrthoDBiEOG7WHH90.
PhylomeDBiB2ZGJ1.
TreeFamiTF313836.

Family and domain databases

InterProiIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERiPTHR22589. PTHR22589. 1 hit.
PfamiPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEiPS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2ZGJ1-1 [UniParc]FASTAAdd to Basket

« Hide

MPVSKREQSK DTGDPCALPK LPIPPLKQTL DMYLTCMGHL VPEDQFRKTK    50
AVVEKFGAPG GVGETLQKKL LERSEQKANW VYDYWLEDMY LNNRLALPVN 100
SSPVMVFHKQ NFKGQSDVLR FAANLISGVL EYKALIDGRA LPVEHARGQL 150
AGTPLCMDQY NKVFTSYRLP GTKTDTLVAQ KSTVMPEPEH IIVACKNQFF 200
VLDVMVNFRR LNEKDLYTQL ERIRKMADIE EERQPPIGLL TSDGRTQWAE 250
ARNILIKDST NRDSLDMIER CLCLVCLDEE TATELNDSNR ALLMLHGGGT 300
DKNGGNRWYD KPMQFVIGAD GCCGVVCEHS PFEGIVLVQC SEYLLRYMRG 350
SPSKLVRAAS MSELPAPRRL RWKCSPDIQT FLSASADRLQ KLVKNLDMNV 400
HKFTGYGKEF IKRQKMSPDA YVQVALQFTF YRCHGRLVPT YESASIRRFQ 450
EGRVDNIRSS TPEALAFVKA MASGSKITDA EKMELLWTAI KAQTNYTILA 500
ITGMAIDNHL LGLREIAKEL KLEKPELFSD TTYATSIHFT LSTSQVPTTE 550
EMFCCYGPVV PNGYGACYNP QTDHILFCVS SFRECAETSS DLFVKTLEGC 600
LKEMQDLCRK CNTEVKPADS TQRMEGNPKV MKNGSKS 637
Length:637
Mass (Da):71,840
Last modified:July 1, 2008 - v1
Checksum:i2379C23ADABC755A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU660883 mRNA. Translation: ACD40042.1.
RefSeqiNP_001124191.1. NM_001130719.1.
XP_005156786.1. XM_005156729.1.
UniGeneiDr.117574.

Genome annotation databases

EnsembliENSDART00000024225; ENSDARP00000025508; ENSDARG00000015854.
ENSDART00000150228; ENSDARP00000125038; ENSDARG00000015854.
GeneIDi100170938.
KEGGidre:100170938.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU660883 mRNA. Translation: ACD40042.1 .
RefSeqi NP_001124191.1. NM_001130719.1.
XP_005156786.1. XM_005156729.1.
UniGenei Dr.117574.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000025508.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000024225 ; ENSDARP00000025508 ; ENSDARG00000015854 .
ENSDART00000150228 ; ENSDARP00000125038 ; ENSDARG00000015854 .
GeneIDi 100170938.
KEGGi dre:100170938.

Organism-specific databases

CTDi 100170938.
ZFINi ZDB-GENE-080102-2. chata.

Phylogenomic databases

eggNOGi NOG70127.
GeneTreei ENSGT00740000115446.
HOGENOMi HOG000233845.
HOVERGENi HBG107717.
KOi K00623.
OMAi HVIVACC.
OrthoDBi EOG7WHH90.
PhylomeDBi B2ZGJ1.
TreeFami TF313836.

Enzyme and pathway databases

Reactomei REACT_174660. Synthesis of PC.

Miscellaneous databases

NextBioi 20795505.
PROi B2ZGJ1.

Gene expression databases

Bgeei B2ZGJ1.

Family and domain databases

InterProi IPR000542. Carn_acyl_trans.
[Graphical view ]
PANTHERi PTHR22589. PTHR22589. 1 hit.
Pfami PF00755. Carn_acyltransf. 1 hit.
[Graphical view ]
PROSITEi PS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Function of neuromuscular synapses in the zebrafish choline-acetyltransferase mutant bajan."
    Wang M., Wen H., Brehm P.
    J. Neurophysiol. 100:1995-2004(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.

Entry informationi

Entry nameiCLAT_DANRE
AccessioniPrimary (citable) accession number: B2ZGJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: July 1, 2008
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi