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Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

Gene

smarcal1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi361 – 3688ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: ZFIN
  • cartilage development Source: ZFIN
  • developmental growth Source: ZFIN
  • DNA metabolic process Source: UniProtKB
  • embryonic body morphogenesis Source: ZFIN
  • hemopoiesis Source: ZFIN
  • mitotic cell cycle Source: ZFIN
  • regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC:3.6.4.-)
Alternative name(s):
HepA-related protein
Sucrose nonfermenting protein 2-like 1
Gene namesi
Name:smarcal1
Synonyms:harp
ORF Names:si:ch211-239d11.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-041210-303. smarcal1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1PRO_0000361533Add
BLAST

Proteomic databases

PaxDbiB2ZFP3.
PeptideAtlasiB2ZFP3.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000106260.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini127 – 19872HARP 1PROSITE-ProRule annotationAdd
BLAST
Domaini231 – 30272HARP 2PROSITE-ProRule annotationAdd
BLAST
Domaini348 – 504157Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini620 – 773154Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili8 – 3326Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi453 – 4564DESH box

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.PROSITE-ProRule annotation
Contains 2 HARP domains.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1000. Eukaryota.
COG0553. LUCA.
HOGENOMiHOG000018734.
HOVERGENiHBG054110.
InParanoidiB2ZFP3.
KOiK14440.
PhylomeDBiB2ZFP3.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR010003. HARP_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF07443. HARP. 2 hits.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51467. HARP. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2ZFP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSLTPEQQ RRIEENRKKA LARRAERQAQ IADPGPAQNK HTQSGTTGGP
60 70 80 90 100
AKNNQHFASD RGQSGAPTRQ TQLIDINAAC TKTAPPTSIT AASTASSFYG
110 120 130 140 150
QAGKPSTGEK RPPKPPEPAA NIPAKKPAVY LRGRCVSHSE NRFRVEVGYH
160 170 180 190 200
ADLILVFKSI PSKNYDPATK MWNFSLEDYQ MLMEQVAHLP SISLKPLEGM
210 220 230 240 250
EGLNISASTC RPKDAAAMAA LMRLCQGWQK PGATIKGKCV LVSRSRLEVD
260 270 280 290 300
IGYQADVIGI FKQMPSKSYD MKTRKWTFLL EDYGKLMADL NELPTVETEP
310 320 330 340 350
LPHAVLQSFS SQFEKTQSQA PVPPEADLSH IDPQLTRSLM PFQRDGVNFA
360 370 380 390 400
VSREGRLLLA DDMGLGKTVQ AICIAAYYRS EWPLLVVAPS SVRFTWAEAF
410 420 430 440 450
RRWLPSVKPD SINVVVKGKD SLRSGLINII SYDLLNKMDK QPPSSPFNVI
460 470 480 490 500
IMDESHFLKN MKTARCRAAL PLLKTAKRVI LLSGTPAMSR PAELYTQIQA
510 520 530 540 550
VRPALFPRFH DFGTRYCDAK QLPWGWDYSS SSNLTELKLL LEESLMLRRL
560 570 580 590 600
KSEVLSQLPA KQRKVVTVTT DGINSRTKAA LNAAARELAK GYHNKSQEKE
610 620 630 640 650
ALLVFFNHTA EAKIRAIMEY ISDMLECGRE KFLVFAHHKL VLDSITKELG
660 670 680 690 700
EKSISFIRID GSTPSAERQL LCERFQASQQ SCVAVLSITA ANMGLTLHSA
710 720 730 740 750
ALVVFAELFW NPGVLIQAED RVHRIGQTSN VDIHYLVAKG TADDYLWPMI
760 770 780 790 800
QAKMNVLEQV GLSESNISEN AESASFHSRD RQQLTITEMF QRSFDEDEML

ALMDQDP
Length:807
Mass (Da):89,896
Last modified:July 1, 2008 - v1
Checksum:iEB65E571C4CB674E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU655703 mRNA. Translation: ACD03327.1.
RefSeqiNP_001120938.1. NM_001127466.1.
UniGeneiDr.105797.

Genome annotation databases

GeneIDi560412.
KEGGidre:560412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU655703 mRNA. Translation: ACD03327.1.
RefSeqiNP_001120938.1. NM_001127466.1.
UniGeneiDr.105797.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000106260.

Proteomic databases

PaxDbiB2ZFP3.
PeptideAtlasiB2ZFP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi560412.
KEGGidre:560412.

Organism-specific databases

CTDi50485.
ZFINiZDB-GENE-041210-303. smarcal1.

Phylogenomic databases

eggNOGiKOG1000. Eukaryota.
COG0553. LUCA.
HOGENOMiHOG000018734.
HOVERGENiHBG054110.
InParanoidiB2ZFP3.
KOiK14440.
PhylomeDBiB2ZFP3.

Miscellaneous databases

PROiB2ZFP3.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR010003. HARP_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF07443. HARP. 2 hits.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51467. HARP. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Deficiency of smarcal1 causes developmental defects through the inhibition of cell proliferation in zebrafish."
    Huang C., Gu S., Yu P., Yu F., Feng C., Gao N., Qin-Zang Y., Du J.
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSMAL1_DANRE
AccessioniPrimary (citable) accession number: B2ZFP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 1, 2008
Last modified: July 6, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.