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B2ZB02

- B2ZB02_BACME

UniProt

B2ZB02 - B2ZB02_BACME

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Protein
Submitted name:

Tyrosinase

Gene
N/A
Organism
Bacillus megaterium
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131Zinc 1; via pros nitrogenImported
Metal bindingi13 – 131Zinc; via pros nitrogen
Metal bindingi42 – 421Copper 1; via tele nitrogenImported
Metal bindingi42 – 421Zinc 2; via tele nitrogenImported
Metal bindingi60 – 601Copper 1; via tele nitrogenImported
Metal bindingi60 – 601Zinc 2; via tele nitrogenImported
Metal bindingi69 – 691Copper 1; via tele nitrogenImported
Metal bindingi69 – 691Zinc 2; via tele nitrogenImported
Metal bindingi204 – 2041Copper 2; via tele nitrogenImported
Metal bindingi204 – 2041Zinc 3; via tele nitrogenImported
Metal bindingi208 – 2081Copper 2; via tele nitrogenImported
Metal bindingi208 – 2081Zinc 3; via tele nitrogenImported
Metal bindingi231 – 2311Copper 2; via tele nitrogenImported
Metal bindingi231 – 2311Zinc 3; via tele nitrogenImported
Metal bindingi287 – 2871Zinc
Metal bindingi287 – 2871Zinc 1Imported

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CopperImported, Metal-bindingImported, ZincImported

Names & Taxonomyi

Protein namesi
Submitted name:
TyrosinaseImported
OrganismiBacillus megateriumImported
Taxonomic identifieri1404 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NM8X-ray2.00A/B1-297[»]
3NPYX-ray2.19A/B1-297[»]
3NQ0X-ray2.20A/B1-297[»]
3NQ1X-ray2.30A/B1-297[»]
3NQ5X-ray2.30A/B1-297[»]
3NTMX-ray2.30A/B1-297[»]
4D87X-ray3.50A/B1-297[»]
4HD4X-ray1.80A/B1-297[»]
4HD6X-ray2.00A/B1-297[»]
4HD7X-ray2.10A/B1-297[»]
4J6TX-ray2.43A/B1-297[»]
4J6UX-ray2.50A/B1-297[»]
4J6VX-ray1.90A/B1-297[»]
4P6RX-ray2.20A/B4-290[»]
4P6SX-ray2.20A/B4-290[»]
4P6TX-ray2.50A/B4-290[»]
ProteinModelPortaliB2ZB02.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiB2ZB02.

Family & Domainsi

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2ZB02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNKYRVRKN VLHLTDTEKR DFVRTVLILK EKGIYDRYIA WHGAAGKFHT
60 70 80 90 100
PPGSDRNAAH MSSAFLPWHR EYLLRFERDL QSINPEVTLP YWEWETDAQM
110 120 130 140 150
QDPSQSQIWS ADFMGGNGNP IKDFIVDTGP FAAGRWTTID EQGNPSGGLK
160 170 180 190 200
RNFGATKEAP TLPTRDDVLN ALKITQYDTP PWDMTSQNSF RNQLEGFING
210 220 230 240 250
PQLHNRVHRW VGGQMGVVPT APNDPVFFLH HANVDRIWAV WQIIHRNQNY
260 270 280 290
QPMKNGPFGQ NFRDPMYPWN TTPEDVMNHR KLGYVYDIEL RKSKRSS
Length:297
Mass (Da):34,410
Last modified:July 1, 2008 - v1
Checksum:iF4CBDE6501B81312
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU627691 Genomic DNA. Translation: ACC86108.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU627691 Genomic DNA. Translation: ACC86108.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3NM8 X-ray 2.00 A/B 1-297 [» ]
3NPY X-ray 2.19 A/B 1-297 [» ]
3NQ0 X-ray 2.20 A/B 1-297 [» ]
3NQ1 X-ray 2.30 A/B 1-297 [» ]
3NQ5 X-ray 2.30 A/B 1-297 [» ]
3NTM X-ray 2.30 A/B 1-297 [» ]
4D87 X-ray 3.50 A/B 1-297 [» ]
4HD4 X-ray 1.80 A/B 1-297 [» ]
4HD6 X-ray 2.00 A/B 1-297 [» ]
4HD7 X-ray 2.10 A/B 1-297 [» ]
4J6T X-ray 2.43 A/B 1-297 [» ]
4J6U X-ray 2.50 A/B 1-297 [» ]
4J6V X-ray 1.90 A/B 1-297 [» ]
4P6R X-ray 2.20 A/B 4-290 [» ]
4P6S X-ray 2.20 A/B 4-290 [» ]
4P6T X-ray 2.50 A/B 4-290 [» ]
ProteinModelPortali B2ZB02.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei B2ZB02.

Family and domain databases

Gene3Di 1.10.1280.10. 1 hit.
InterProi IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
Pfami PF00264. Tyrosinase. 1 hit.
[Graphical view ]
PRINTSi PR00092. TYROSINASE.
SUPFAMi SSF48056. SSF48056. 1 hit.
PROSITEi PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation, cloning and characterization of a tyrosinase with improved activity in organic solvents from Bacillus megaterium."
    Shuster V., Fishman A.
    J. Mol. Microbiol. Biotechnol. 17:188-200(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: VS1Imported.
  2. "First structures of an active bacterial tyrosinase reveal copper plasticity."
    Sendovski M., Kanteev M., Ben-Yosef V.S., Adir N., Fishman A.
    J. Mol. Biol. 405:227-237(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH COPPER AND ZINC.
  3. "Changes in tyrosinase specificity by ionic liquids and sodium dodecyl sulfate."
    Goldfeder M., Egozy M., Shuster Ben-Yosef V., Adir N., Fishman A.
    Appl. Microbiol. Biotechnol. 97:1953-1961(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS) IN COMPLEX WITH COPPER.
  4. "Influencing the monophenolase/diphenolase activity ratio in tyrosinase."
    Goldfeder M., Kanteev M., Adir N., Fishman A.
    Biochim. Biophys. Acta 1834:629-633(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH COPPER.
  5. "The mechanism of copper uptake by tyrosinase from Bacillus megaterium."
    Kanteev M., Goldfeder M., Chojnacki M., Adir N., Fishman A.
    J. Biol. Inorg. Chem. 18:895-903(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH COPPER.
  6. "Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins."
    Goldfeder M., Kanteev M., Isaschar-Ovdat S., Adir N., Fishman A.
    Nat. Commun. 5:4505-4505(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 4-290 IN COMPLEX WITH COPPER AND ZINC.

Entry informationi

Entry nameiB2ZB02_BACME
AccessioniPrimary (citable) accession number: B2ZB02
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3