Tyrosinase - Bacillus megaterium

Preferred order of sections

Names and origin

Protein names	Submitted name: Tyrosinase EMBL ACC86108.1
Organism	Bacillus megaterium EMBL ACC86108.1
Taxonomic identifier	1404 [NCBI]
Taxonomic lineage	cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Copper PDB 3NM8 PDB 3NPY PDB 3NQ5 PDB 3NQ0 PDB 3NQ1 PDB 3NTM Metal-binding PDB 3NM8 PDB 3NPY PDB 3NQ5 PDB 3NQ0 PDB 3NQ1 PDB 3NTM Zinc PDB 3NM8 PDB 3NPY PDB 3NQ5 PDB 3NQ1
Technical term	3D-structure PDB 3NM8 PDB 3NPY PDB 3NQ5 PDB 3NQ0 PDB 3NQ1 PDB 3NTM PDB 4D87 PDB 4HD4 PDB 4HD6 PDB 4HD7
Gene Ontology (GO)
Biological_process	oxidation-reduction process Inferred from electronic annotation. Source: GOC
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

13

1

Zinc; via pros nitrogen PDB 3NQ5

Metal binding

42

1

Copper 1; via tele nitrogen PDB 3NQ0 PDB 3NTM

Metal binding

60

1

Copper 1; via tele nitrogen PDB 3NQ0 PDB 3NTM

Metal binding

69

1

Copper 1; via tele nitrogen PDB 3NQ0 PDB 3NTM

Metal binding

204

1

Copper 2; via tele nitrogen PDB 3NM8 PDB 3NPY PDB 3NQ5 PDB 3NQ1 PDB 3NTM

Metal binding

208

1

Copper 2; via tele nitrogen PDB 3NM8 PDB 3NPY PDB 3NQ5 PDB 3NQ1 PDB 3NTM

Metal binding

231

1

Copper 2; via tele nitrogen PDB 3NM8 PDB 3NPY PDB 3NQ5 PDB 3NQ1 PDB 3NTM

Metal binding

287

1

Zinc PDB 3NQ5

Sequences

Sequence

Length

Mass (Da)

Tools

B2ZB02 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: F4CBDE6501B81312
Show »

FASTA

297

34,410

        10         20         30         40         50         60 
MSNKYRVRKN VLHLTDTEKR DFVRTVLILK EKGIYDRYIA WHGAAGKFHT PPGSDRNAAH 

        70         80         90        100        110        120 
MSSAFLPWHR EYLLRFERDL QSINPEVTLP YWEWETDAQM QDPSQSQIWS ADFMGGNGNP 

       130        140        150        160        170        180 
IKDFIVDTGP FAAGRWTTID EQGNPSGGLK RNFGATKEAP TLPTRDDVLN ALKITQYDTP 

       190        200        210        220        230        240 
PWDMTSQNSF RNQLEGFING PQLHNRVHRW VGGQMGVVPT APNDPVFFLH HANVDRIWAV 

       250        260        270        280        290 
WQIIHRNQNY QPMKNGPFGQ NFRDPMYPWN TTPEDVMNHR KLGYVYDIEL RKSKRSS

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References

[1]	"Isolation, cloning and characterization of a tyrosinase with improved activity in organic solvents from Bacillus megaterium." Shuster V., Fishman A. J. Mol. Microbiol. Biotechnol. 17:188-200(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: VS1 EMBL ACC86108.1.
[2]	"First structures of an active bacterial tyrosinase reveal copper plasticity." Sendovski M., Kanteev M., Ben-Yosef V.S., Adir N., Fishman A. J. Mol. Biol. 405:227-237(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH COPPER AND ZINC.
[3]	"Changes in tyrosinase specificity by ionic liquids and sodium dodecyl sulfate." Goldfeder M., Egozy M., Shuster Ben-Yosef V., Adir N., Fishman A. Appl. Microbiol. Biotechnol. 97:1953-1961(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS).
[4]	"Influencing the monophenolase/diphenolase activity ratio in tyrosinase." Goldfeder M., Kanteev M., Adir N., Fishman A. Biochim. Biophys. Acta 1834:629-633(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 3-297.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

EU627691 Genomic DNA. Translation: ACC86108.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3NM8	X-ray	2.00	A/B	1-297	[»]
3NPY	X-ray	2.19	A/B	1-297	[»]
3NQ0	X-ray	2.20	A/B	1-297	[»]
3NQ1	X-ray	2.30	A/B	1-297	[»]
3NQ5	X-ray	2.30	A/B	1-297	[»]
3NTM	X-ray	2.30	A/B	1-297	[»]
4D87	X-ray	3.50	A/B	1-297	[»]
4HD4	X-ray	1.80	A/B	3-297	[»]
4HD6	X-ray	2.00	A/B	3-297	[»]
4HD7	X-ray	2.10	A/B	3-297	[»]

ProteinModelPortal

B2ZB02.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

1.10.1280.10. 1 hit.

InterPro

IPR002227. Tyrosinase.
IPR008922. Unchr_di-copper_centre.
[Graphical view]

Pfam

PF00264. Tyrosinase. 1 hit.
[Graphical view]

PRINTS

PR00092. TYROSINASE.

SUPFAM

SSF48056. Di-copper_centre. 1 hit.

PROSITE

PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

B2ZB02.

Entry information

Entry name

B2ZB02_BACME

Accession

Primary (citable) accession number: B2ZB02

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	May 1, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)