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Protein
Submitted name:

Tyrosinase

Gene
N/A
Organism
Bacillus megaterium
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi13Zinc 1; via pros nitrogenCombined sources1
Metal bindingi42Copper 1; via tele nitrogenCombined sources1
Metal bindingi42Zinc 2; via tele nitrogenCombined sources1
Metal bindingi60Copper 1; via tele nitrogenCombined sources1
Metal bindingi60Zinc 2; via tele nitrogenCombined sources1
Metal bindingi69Copper 1; via tele nitrogenCombined sources1
Metal bindingi69Zinc 2; via tele nitrogenCombined sources1
Metal bindingi204Copper 2; via tele nitrogenCombined sources1
Metal bindingi204Zinc 3; via tele nitrogenCombined sources1
Metal bindingi208Copper 2; via tele nitrogenCombined sources1
Metal bindingi208Zinc 3; via tele nitrogenCombined sources1
Metal bindingi231Copper 2; via tele nitrogenCombined sources1
Metal bindingi231Zinc 3; via tele nitrogenCombined sources1
Metal bindingi287Zinc 1Combined sources1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

CopperCombined sources, Metal-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BRENDAi1.14.18.1. 656.

Names & Taxonomyi

Protein namesi
Submitted name:
TyrosinaseImported
OrganismiBacillus megateriumImported
Taxonomic identifieri1404 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Interactioni

Protein-protein interaction databases

STRINGi545693.BMQ_3385.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NM8X-ray2.00A/B1-297[»]
3NPYX-ray2.19A/B1-297[»]
3NQ0X-ray2.20A/B1-297[»]
3NQ1X-ray2.30A/B1-297[»]
3NQ5X-ray2.30A/B1-297[»]
3NTMX-ray2.30A/B1-297[»]
4D87X-ray3.50A/B1-297[»]
4HD4X-ray1.80A/B1-297[»]
4HD6X-ray2.00A/B1-297[»]
4HD7X-ray2.10A/B1-297[»]
4J6TX-ray2.43A/B1-297[»]
4J6UX-ray2.50A/B1-297[»]
4J6VX-ray1.90A/B1-297[»]
4P6RX-ray2.20A/B4-290[»]
4P6SX-ray2.20A/B4-290[»]
4P6TX-ray2.50A/B4-290[»]
ProteinModelPortaliB2ZB02.
SMRiB2ZB02.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiB2ZB02.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 77Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini224 – 235Tyrosinase_Cu-bdInterPro annotationAdd BLAST12

Phylogenomic databases

eggNOGiENOG4108VB6. Bacteria.
ENOG4111JCJ. LUCA.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2ZB02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKYRVRKN VLHLTDTEKR DFVRTVLILK EKGIYDRYIA WHGAAGKFHT
60 70 80 90 100
PPGSDRNAAH MSSAFLPWHR EYLLRFERDL QSINPEVTLP YWEWETDAQM
110 120 130 140 150
QDPSQSQIWS ADFMGGNGNP IKDFIVDTGP FAAGRWTTID EQGNPSGGLK
160 170 180 190 200
RNFGATKEAP TLPTRDDVLN ALKITQYDTP PWDMTSQNSF RNQLEGFING
210 220 230 240 250
PQLHNRVHRW VGGQMGVVPT APNDPVFFLH HANVDRIWAV WQIIHRNQNY
260 270 280 290
QPMKNGPFGQ NFRDPMYPWN TTPEDVMNHR KLGYVYDIEL RKSKRSS
Length:297
Mass (Da):34,410
Last modified:July 1, 2008 - v1
Checksum:iF4CBDE6501B81312
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU627691 Genomic DNA. Translation: ACC86108.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU627691 Genomic DNA. Translation: ACC86108.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NM8X-ray2.00A/B1-297[»]
3NPYX-ray2.19A/B1-297[»]
3NQ0X-ray2.20A/B1-297[»]
3NQ1X-ray2.30A/B1-297[»]
3NQ5X-ray2.30A/B1-297[»]
3NTMX-ray2.30A/B1-297[»]
4D87X-ray3.50A/B1-297[»]
4HD4X-ray1.80A/B1-297[»]
4HD6X-ray2.00A/B1-297[»]
4HD7X-ray2.10A/B1-297[»]
4J6TX-ray2.43A/B1-297[»]
4J6UX-ray2.50A/B1-297[»]
4J6VX-ray1.90A/B1-297[»]
4P6RX-ray2.20A/B4-290[»]
4P6SX-ray2.20A/B4-290[»]
4P6TX-ray2.50A/B4-290[»]
ProteinModelPortaliB2ZB02.
SMRiB2ZB02.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi545693.BMQ_3385.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108VB6. Bacteria.
ENOG4111JCJ. LUCA.

Enzyme and pathway databases

BRENDAi1.14.18.1. 656.

Miscellaneous databases

EvolutionaryTraceiB2ZB02.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2ZB02_BACME
AccessioniPrimary (citable) accession number: B2ZB02
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 2, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.