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B2ZB02

- B2ZB02_BACME

UniProt

B2ZB02 - B2ZB02_BACME

Protein
Submitted name:

Tyrosinase

Gene
N/A
Organism
Bacillus megaterium
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi13 – 131Zinc; via pros nitrogen
    Metal bindingi42 – 421Copper 1; via tele nitrogenImported
    Metal bindingi60 – 601Copper 1; via tele nitrogenImported
    Metal bindingi69 – 691Copper 1; via tele nitrogenImported
    Metal bindingi204 – 2041Copper 2; via tele nitrogenImported
    Metal bindingi208 – 2081Copper 2; via tele nitrogenImported
    Metal bindingi231 – 2311Copper 2; via tele nitrogenImported
    Metal bindingi287 – 2871Zinc

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. oxidoreductase activity Source: InterPro

    Keywords - Ligandi

    CopperImported, Metal-bindingImported, ZincImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    TyrosinaseImported
    OrganismiBacillus megateriumImported
    Taxonomic identifieri1404 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3NM8X-ray2.00A/B1-297[»]
    3NPYX-ray2.19A/B1-297[»]
    3NQ0X-ray2.20A/B1-297[»]
    3NQ1X-ray2.30A/B1-297[»]
    3NQ5X-ray2.30A/B1-297[»]
    3NTMX-ray2.30A/B1-297[»]
    4D87X-ray3.50A/B1-297[»]
    4HD4X-ray1.80A/B1-297[»]
    4HD6X-ray2.00A/B1-297[»]
    4HD7X-ray2.10A/B1-297[»]
    4J6TX-ray2.43A/B1-297[»]
    4J6UX-ray2.50A/B1-297[»]
    4J6VX-ray1.90A/B1-297[»]
    4P6RX-ray2.20A/B4-290[»]
    4P6SX-ray2.20A/B4-290[»]
    4P6TX-ray2.50A/B4-290[»]
    ProteinModelPortaliB2ZB02.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiB2ZB02.

    Family & Domainsi

    Family and domain databases

    Gene3Di1.10.1280.10. 1 hit.
    InterProiIPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view]
    PfamiPF00264. Tyrosinase. 1 hit.
    [Graphical view]
    PRINTSiPR00092. TYROSINASE.
    SUPFAMiSSF48056. SSF48056. 1 hit.
    PROSITEiPS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2ZB02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNKYRVRKN VLHLTDTEKR DFVRTVLILK EKGIYDRYIA WHGAAGKFHT    50
    PPGSDRNAAH MSSAFLPWHR EYLLRFERDL QSINPEVTLP YWEWETDAQM 100
    QDPSQSQIWS ADFMGGNGNP IKDFIVDTGP FAAGRWTTID EQGNPSGGLK 150
    RNFGATKEAP TLPTRDDVLN ALKITQYDTP PWDMTSQNSF RNQLEGFING 200
    PQLHNRVHRW VGGQMGVVPT APNDPVFFLH HANVDRIWAV WQIIHRNQNY 250
    QPMKNGPFGQ NFRDPMYPWN TTPEDVMNHR KLGYVYDIEL RKSKRSS 297
    Length:297
    Mass (Da):34,410
    Last modified:July 1, 2008 - v1
    Checksum:iF4CBDE6501B81312
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU627691 Genomic DNA. Translation: ACC86108.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU627691 Genomic DNA. Translation: ACC86108.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3NM8 X-ray 2.00 A/B 1-297 [» ]
    3NPY X-ray 2.19 A/B 1-297 [» ]
    3NQ0 X-ray 2.20 A/B 1-297 [» ]
    3NQ1 X-ray 2.30 A/B 1-297 [» ]
    3NQ5 X-ray 2.30 A/B 1-297 [» ]
    3NTM X-ray 2.30 A/B 1-297 [» ]
    4D87 X-ray 3.50 A/B 1-297 [» ]
    4HD4 X-ray 1.80 A/B 1-297 [» ]
    4HD6 X-ray 2.00 A/B 1-297 [» ]
    4HD7 X-ray 2.10 A/B 1-297 [» ]
    4J6T X-ray 2.43 A/B 1-297 [» ]
    4J6U X-ray 2.50 A/B 1-297 [» ]
    4J6V X-ray 1.90 A/B 1-297 [» ]
    4P6R X-ray 2.20 A/B 4-290 [» ]
    4P6S X-ray 2.20 A/B 4-290 [» ]
    4P6T X-ray 2.50 A/B 4-290 [» ]
    ProteinModelPortali B2ZB02.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei B2ZB02.

    Family and domain databases

    Gene3Di 1.10.1280.10. 1 hit.
    InterProi IPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view ]
    Pfami PF00264. Tyrosinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00092. TYROSINASE.
    SUPFAMi SSF48056. SSF48056. 1 hit.
    PROSITEi PS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, cloning and characterization of a tyrosinase with improved activity in organic solvents from Bacillus megaterium."
      Shuster V., Fishman A.
      J. Mol. Microbiol. Biotechnol. 17:188-200(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: VS1Imported.
    2. "First structures of an active bacterial tyrosinase reveal copper plasticity."
      Sendovski M., Kanteev M., Ben-Yosef V.S., Adir N., Fishman A.
      J. Mol. Biol. 405:227-237(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH COPPER AND ZINC.
    3. "Changes in tyrosinase specificity by ionic liquids and sodium dodecyl sulfate."
      Goldfeder M., Egozy M., Shuster Ben-Yosef V., Adir N., Fishman A.
      Appl. Microbiol. Biotechnol. 97:1953-1961(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS) IN COMPLEX WITH COPPER.
    4. "Influencing the monophenolase/diphenolase activity ratio in tyrosinase."
      Goldfeder M., Kanteev M., Adir N., Fishman A.
      Biochim. Biophys. Acta 1834:629-633(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH COPPER.
    5. "The mechanism of copper uptake by tyrosinase from Bacillus megaterium."
      Kanteev M., Goldfeder M., Chojnacki M., Adir N., Fishman A.
      J. Biol. Inorg. Chem. 18:895-903(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH COPPER.

    Entry informationi

    Entry nameiB2ZB02_BACME
    AccessioniPrimary (citable) accession number: B2ZB02
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3