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Protein
Submitted name:

5-HT2C receptor

Gene

htr2cl1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
5-HT2C receptorImported
Gene namesi
Name:htr2cl1Imported
Synonyms:5-ht2crImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-081104-48. htr2cl1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei70 – 93HelicalSequence analysisAdd BLAST24
Transmembranei105 – 124HelicalSequence analysisAdd BLAST20
Transmembranei144 – 165HelicalSequence analysisAdd BLAST22
Transmembranei186 – 207HelicalSequence analysisAdd BLAST22
Transmembranei227 – 250HelicalSequence analysisAdd BLAST24
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei397 – 419HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiB2WSB2.

Structurei

3D structure databases

ProteinModelPortaliB2WSB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 416G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST332

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000240378.
HOVERGENiHBG107487.

Family and domain databases

InterProiView protein in InterPro
IPR000377. 5HT2C_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PANTHERiPTHR24247:SF32. PTHR24247:SF32. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B2WSB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGAPGGPVL GGFSSTTSSL DLVGWMIWPG NTTVSLNQSF FGTDYSFNLS
60 70 80 90 100
SSSSSSPHGV KREEMKEKNW PALLILVIII LTIEGNILVI LAVSLEKKLQ
110 120 130 140 150
NATNFFLRSL AVADMLVGIL VMPISLINIL YDYAWPLPSA LCPIWIYLDV
160 170 180 190 200
LFSTASIMHL CAISLDRYVA IRNPIEHSRF NSRTKAMLKI AAVWTISIGI
210 220 230 240 250
SMPIPVIGLS NREKVLKNGI CALNEELFIL VGSFVAFFIP LVIMVVTYCL
260 270 280 290 300
TVQALQRQAT VFLYEGKASS QQPLQPPAPP SSQLVPPLAP SRRSSLNCLR
310 320 330 340 350
ISNSDGNTLG LTVPPDTISI IPSSEAPSQM NSPAGRDPAG AHGRRGMMQA
360 370 380 390 400
IKNERRASKV LGVVFFLFLF MWCPFFVTNV LYVLCHRTCK ETLLTELLNV
410 420 430 440 450
FVWVGYISSG VNPLVYTLFN KTYRRAFSNY MHCQYRHVGL KPITINVPCP
460 470 480 490 500
SHAVVTPILM CDKVSIDRNS NCRNGDGNGI RNLETLDIDT DTGLELKPGI
510
SEISISSGHS HTEHTSSV
Length:518
Mass (Da):56,897
Last modified:July 1, 2008 - v1
Checksum:i7D24C720672D2842
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF207947 mRNA. Translation: ABP04055.1.
RefSeqiNP_001123365.1. NM_001129893.1.
UniGeneiDr.134134.

Genome annotation databases

GeneIDi100000981.

Similar proteinsi

Entry informationi

Entry nameiB2WSB2_DANRE
AccessioniPrimary (citable) accession number: B2WSB2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 22, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)