B2WMQ2 (AMPP3_PYRTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase pepP
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	pepP
ORF Names:	PTRG_11262

Organism

Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis) [Complete proteome]

Taxonomic identifier

426418 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › dothideomyceta › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporineae › Pleosporaceae › Pyrenophora › Pyrenophora tritici-repentis

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	Probable Xaa-Pro aminopeptidase pepP		PRO_0000411886
Sites
	Metal binding	259	1	Manganese 2 By similarity
	Metal binding	270	1	Manganese 1 By similarity
	Metal binding	270	1	Manganese 2 By similarity
	Metal binding	393	1	Manganese 1 By similarity
	Metal binding	433	1	Manganese 1 By similarity
	Metal binding	433	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2WMQ2 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: F74145C5533E74B4	FASTA	463	52,110
	10 20 30 40 50 60 MAIAENYEDV LKGKYPAKAH AKKVAEWIIA KGGDKNGTIY LEAQKQKLNE DNDGEAPFRQ 70 80 90 100 110 120 RRYFFYLSGC ELPDSYLTYE IATEKLTLFI PPVEPDEVIW SGLPMSPEEA KEKYDIDQCL 130 140 150 160 170 180 TTKDVNAHLT STSESAQSTI YAIPEQVSDH ITFISYKEKE FKQLKPAIEY CRVIKSDYEI 190 200 210 220 230 240 ALIRKANIIS TAAHEAVMKA ASTAKNECEL EAVFLKACVE RNAKNQAYHS IVAAGEHAAT 250 260 270 280 290 300 LHYVHNAAPI SDQNLLLLDA GCEVDCYASD ITRTFPLKGK FTTESLAIYK IVLDMQHQCI 310 320 330 340 350 360 NALKEGVVWD SVHELAHKVA IKGLLELGIL KGDAEEIFTK RISVAFFPHG LGHYLGMDTH 370 380 390 400 410 420 DTGGNPNYAD KDVMFRYLRT RGSLPERSVI TVEPGVYFCR FIIEPYLKDE EKKKYIDESV 430 440 450 460 LEKYWSVGGV RIEDNVLVTK NGFENLTPTP KEIDDITKLI LST

References

[1]

"Genome sequence of Pyrenophora tritici-repentis." Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., MacCallum I.A., Young S.K., LaButti K., DeCaprio D. , Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., White J., Yandava C., Kodira C.D., Guigo R., Borodovsky M., Zeng Q., O'Leary S., Alvarado L., Pandelova I., Ciuffetti L. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pt-1C-BFP.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS231630 Genomic DNA. Translation: EDU44312.1.
RefSeq	XP_001941593.1. XM_001941558.1.
3D structure databases
ProteinModelPortal	B2WMQ2.
ModBase	Search...
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6349575.
Phylogenomic databases
OrthoDB	EOG4J40RD.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP3_PYRTR

Accession

Primary (citable) accession number: B2WMQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	July 1, 2008
Last modified:	March 6, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program