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B2WME4 (MTLD_PYRTR) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
Short name=M1PDH
Short name=MPD
Short name=MPDH
EC=1.1.1.17
Gene names
ORF Names:PTRG_11154
OrganismPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis) [Complete proteome]
Taxonomic identifier426418 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporineae › Pleosporaceae › Pyrenophora

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Mannitol-1-phosphate 5-dehydrogenase
PRO_0000371536

Regions

Nucleotide binding7 – 1812NAD By similarity

Sites

Active site2161 By similarity

Sequences

Sequence LengthMass (Da)Tools
B2WME4 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 68CDA666C271B70A

FASTA38943,570
        10         20         30         40         50         60 
MPYEKKAVHF GGGNIGRGFV AEFLHNSGYE VVFVDVMDSI IESLQKTSTY KVTEIGDDGE 

        70         80         90        100        110        120 
REFTIDHYRA INSKNEMDKV IEEIATADVV TCAVGPNILK FVAEPVAKAI EARKLDYPIA 

       130        140        150        160        170        180 
VIACENAINA TTTWRGFIES KLSEETKKNI DSKARFANSA IDRIVPQQPP NAGLNVVIEK 

       190        200        210        220        230        240 
FHEWCVEQKP FENGGKKPDV KGIHYVDDLE PYIERKLFTV NTSHATAAYY GHQNKIAYIH 

       250        260        270        280        290        300 
EVLQDKKLHD IVRDAVKETA NLIVKKHGVS TQEQSDYVEQ IIKRISNPVL KDNVERVGRA 

       310        320        330        340        350        360 
PLRKLSRKER FIGPAAQLAE RGESYQTLLG AVEQAYRFQN VEGDEESVEL AKILKEHSPE 

       370        380 
EVVTKVNGIE KGHALFDPLV AIVKKVQGS

« Hide

References

[1]"Genome sequence of Pyrenophora tritici-repentis."
Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., MacCallum I.A., Young S.K., LaButti K., DeCaprio D. expand/collapse author list , Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., White J., Yandava C., Kodira C.D., Guigo R., Borodovsky M., Zeng Q., O'Leary S., Alvarado L., Pandelova I., Ciuffetti L.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pt-1C-BFP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DS231630 Genomic DNA. Translation: EDU44204.1.
RefSeqXP_001941485.1. XM_001941450.1.

3D structure databases

ProteinModelPortalB2WME4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6349466.

Phylogenomic databases

OrthoDBEOG469V3C.
PhylomeDBB2WME4.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_PYRTR
AccessionPrimary (citable) accession number: B2WME4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 1, 2008
Last modified: December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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