Reviewed, UniProtKB/Swiss-Prot B2WME4 (MTLD_PYRTR)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
      Short name=M1PDH
      Short name=MPDH
      Short name=MPD
    EC=1.1.1.17

Gene names

ORF Names:

PTRG_11154

Organism

Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)

Taxonomic identifier

426418 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporaceae › Pyrenophora

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.
Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000371536
Regions
	Nucleotide binding	7 – 18	12	NAD By similarity
Sites
	Active site	216	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2WME4-1 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 68CDA666C271B70A	FASTA	389	43,570
	10 20 30 40 50 60 MPYEKKAVHF GGGNIGRGFV AEFLHNSGYE VVFVDVMDSI IESLQKTSTY KVTEIGDDGE 70 80 90 100 110 120 REFTIDHYRA INSKNEMDKV IEEIATADVV TCAVGPNILK FVAEPVAKAI EARKLDYPIA 130 140 150 160 170 180 VIACENAINA TTTWRGFIES KLSEETKKNI DSKARFANSA IDRIVPQQPP NAGLNVVIEK 190 200 210 220 230 240 FHEWCVEQKP FENGGKKPDV KGIHYVDDLE PYIERKLFTV NTSHATAAYY GHQNKIAYIH 250 260 270 280 290 300 EVLQDKKLHD IVRDAVKETA NLIVKKHGVS TQEQSDYVEQ IIKRISNPVL KDNVERVGRA 310 320 330 340 350 360 PLRKLSRKER FIGPAAQLAE RGESYQTLLG AVEQAYRFQN VEGDEESVEL AKILKEHSPE 370 380 EVVTKVNGIE KGHALFDPLV AIVKKVQGS

References

[1]

"Genome sequence of Pyrenophora tritici-repentis." Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., MacCallum I.A., Young S.K., LaButti K., DeCaprio D. , Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., White J., Yandava C., Kodira C.D., Guigo R., Borodovsky M., Zeng Q., O'Leary S., Alvarado L., Pandelova I., Ciuffetti L. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DS231630 Genomic DNA. Translation: EDU44204.1.
RefSeq	XP_001941485.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6349466.
Family and domain databases
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_PYRTR

Accession

Primary (citable) accession number: B2WME4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	July 1, 2008
Last modified:	June 16, 2009
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)