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B2WKF1

- CBPYA_PYRTR

UniProt

B2WKF1 - CBPYA_PYRTR

Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei266 – 2661PROSITE-ProRule annotation
    Active sitei457 – 4571PROSITE-ProRule annotation
    Active sitei516 – 5161PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:cpyA
    ORF Names:PTRG_10461
    OrganismiPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
    Taxonomic identifieri426418 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora
    ProteomesiUP000001471: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 125108By similarityPRO_0000407474Add
    BLAST
    Chaini126 – 541416Carboxypeptidase Y homolog APRO_0000407475Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi179 ↔ 418By similarity
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi313 ↔ 327By similarity
    Disulfide bondi337 ↔ 360By similarity
    Disulfide bondi344 ↔ 353By similarity
    Disulfide bondi382 ↔ 388By similarity
    Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B2WKF1-1 [UniParc]FASTAAdd to Basket

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    MKVATSALLI GAAAAQQQQI LKFPDSFSEL KESSWTKPLQ NLEESLKSLT    50
    GEARATWDEI AMMFPESFEK AAFFSEPKPH TRKQDSEWDH IIKGADIQSV 100
    WVENEKGEKE REIDGKLEQY SLRAKKVDPS VLGVDKVKQY SGYLDDEEED 150
    KHLFYWFFES RNDPKNDPVV LWLNGGPGCS SLTGLFMELG PASITKDQKI 200
    KHNPYSWNSN ASVIFLDQPV NVGYSYSSGS VSNTVAAGKD IYALLTLFFK 250
    QFPEYSHQSF HISGESYAGH YIPVFASEIL SHKNRNINLQ SVLIGNGLTD 300
    GLTQYEYYRP MACGEGGWPA VLDESQCKAM DNAYPRCASL IENCYNSESV 350
    WSCVPASIYC NNAMIGPYQR TGQNVYDVRK PCGSNSLCYD ELDWIQGYLN 400
    KKEVMKAVGA EVSNYESCNF DINRNFLLQG DWMKPFHRVV PGILEKIPVL 450
    IYAGDADYIC NWLGNKAWTE ALEWPGAKAY NQAKMEDFKI DGDGKTVGQV 500
    KSSGNFTFMR LHAGGHMVPY DQPEASLEML NRWLGGGFWK A 541
    Length:541
    Mass (Da):60,888
    Last modified:July 1, 2008 - v1
    Checksum:iC6380578F2E78391
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231628 Genomic DNA. Translation: EDU43511.1.
    RefSeqiXP_001940792.1. XM_001940757.1.

    Genome annotation databases

    EnsemblFungiiEDU43511; EDU43511; PTRG_10461.
    GeneIDi6348766.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231628 Genomic DNA. Translation: EDU43511.1 .
    RefSeqi XP_001940792.1. XM_001940757.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EDU43511 ; EDU43511 ; PTRG_10461 .
    GeneIDi 6348766.

    Phylogenomic databases

    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-repentis, reveals transduplication and the impact of repeat elements on pathogenicity and population divergence."
      Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B., Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H., Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W., Schwartz D.C., Spatafora J.W.
      , Turgeon B.G., Yandava C., Young S., Zhou S., Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.
      G3 (Bethesda) 3:41-63(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pt-1C-BFP.

    Entry informationi

    Entry nameiCBPYA_PYRTR
    AccessioniPrimary (citable) accession number: B2WKF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3