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Protein

Catalase-peroxidase

Gene

katG

Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei90Transition state stabilizerUniRule annotation1
Active sitei94Proton acceptorUniRule annotation1
Metal bindingi283Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
ORF Names:PTRG_09343
OrganismiPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Taxonomic identifieri426418 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora
Proteomesi
  • UP000001471 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003541111 – 760Catalase-peroxidaseAdd BLAST760

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki93 ↔ 242Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-268)UniRule annotation
Cross-linki242 ↔ 268Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-93)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiB2WH84.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi426418.XP_001939675.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IEWS. Eukaryota.
COG0376. LUCA.
InParanoidiB2WH84.
OrthoDBiEOG092C0YTX.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 3 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2WH84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGECPVKK VPNVAGSGTR NTDWWPNELR TNILRQHDPR QNPLGPDFNY
60 70 80 90 100
VEEFKKLDYD ALKKDLNALM TDSQDWWPAD FGHYGGLFIR MAWHSAGTYR
110 120 130 140 150
VTDGRGGGGD GQQRFAPLNA WPDNVSLDKA RRLLWPIKQK YGNKISWADL
160 170 180 190 200
MLLTGNVALE SMGCPTFGFA GGRADTFQSD ESVYWGGETE WLGSDVRYAD
210 220 230 240 250
GAKGVKGEGI MDGDQHKTDK SEPHTSRNLE QPLAAAHMGL IYVNPEGPEG
260 270 280 290 300
IPDPVAAAHD IRTTFGRMAM NDAETAALII GGHSFGKTHG AAPSENTGPD
310 320 330 340 350
PNSEDLATQG FGWMNKHGRG NGPDTITSGL EVTWTGTPTK WSNKYLEYLY
360 370 380 390 400
KFEWELEKSP AGANQWVAKT DEHIIPDAYD QNKKHKPRML TTDLAMRMDP
410 420 430 440 450
AYEKITRRWL EHPQELHDTF VRAWFKLLHR DMGPRSRWLG PEVPKEVLIW
460 470 480 490 500
EDPVPQPEGE LIGESDIATL KKQVLDAGVE PAKLIRTAWA SAASFRGSDK
510 520 530 540 550
RGGANGARIR LAPQKDWEVN NPKELAEVLK ALEGVQSKFN SGSKKVSLAD
560 570 580 590 600
LIVLAGTAAV EKAAGVQVPF TPGRTDATQE QTDAKSFEHL EPVTDGFRNY
610 620 630 640 650
GKGTDRVRTE QLDVDKAHLL RLTAPEMVVL TGGMRALNAN WDGSSHGVFT
660 670 680 690 700
KRPGQLTNDF FVNLLDNNLE WKAADSSKEL YEGFDRKSGQ KKWTATRHDL
710 720 730 740 750
VFGHHPELRA VAETYAQADN TDKFVKDFVA GWEKIMNNDR FDIKNKSVSA
760
QSRGANKPRL
Length:760
Mass (Da):84,558
Last modified:July 1, 2008 - v1
Checksum:iD58CD69D18472B54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231625 Genomic DNA. Translation: EDU42394.1.
RefSeqiXP_001939675.1. XM_001939640.1.

Genome annotation databases

EnsemblFungiiEDU42394; EDU42394; PTRG_09343.
GeneIDi6347633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231625 Genomic DNA. Translation: EDU42394.1.
RefSeqiXP_001939675.1. XM_001939640.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi426418.XP_001939675.1.

Proteomic databases

PRIDEiB2WH84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEDU42394; EDU42394; PTRG_09343.
GeneIDi6347633.

Phylogenomic databases

eggNOGiENOG410IEWS. Eukaryota.
COG0376. LUCA.
InParanoidiB2WH84.
OrthoDBiEOG092C0YTX.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 3 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_PYRTR
AccessioniPrimary (citable) accession number: B2WH84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 1, 2008
Last modified: September 7, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.