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B2WC36

- DAPB_PYRTR

UniProt

B2WC36 - DAPB_PYRTR

Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei724 – 7241Charge relay systemBy similarity
    Active sitei801 – 8011Charge relay systemBy similarity
    Active sitei834 – 8341Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:dapB
    ORF Names:PTRG_07545
    OrganismiPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
    Taxonomic identifieri426418 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora
    ProteomesiUP000001471: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 880880Probable dipeptidyl-aminopeptidase BPRO_0000412160Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi533 – 5331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi778 – 7781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliB2WC36.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9393CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini115 – 880766VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei94 – 11421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2WC36-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRQRAPKEE EAELLTKQER SARSSEDASD TSISSISTTS LVLEHINDPA    50
    INGTSRSRRG EKYTDEDDEA QEAFDVEGGR YKSPISVDKK TRRWLWIVGI 100
    ACVTGWALAL VFFLMSGSYK HVSTRPHDPL ASSTKGSGKK ITMDDVFGGR 150
    FYAREQSLKW IAGPNGEDGL LLERDAGNAE YLVVEDIRNK GDGDSSAKKT 200
    KLMQKSGFNV NGYFVRPVEV WPSKDFKKTG EPLDPENQDG RVQLASLSPQ 250
    SDAVVFTRNN NMYLRKLDSK EVIQITRDGG SELFYGIPDW VYEEEVFQTN 300
    SATWWSEDGK YIAFLRTDES TVPTYPVQYF VSRPSGDKPK AGEENYPEVR 350
    NIKYPKAGAP NPIVTLQFYD VEKAEVFSVE IEDDFRDNNR LITEIVWAGK 400
    TKQVLVRETN RESDILKVVL MDVEKRTGKT VRTENVAELD GGWFEVSQKT 450
    TFVPADPANG RKDDGYIDTI IHEGYDHIGY FTPLDNDKPI VLSQGEWEVV 500
    DAPSRVDLKN NIVYYISTAK SSMERHAYSV FLNGTGTSEV VENSGSGYYG 550
    ASFSAGGSYA LITYQGPGIP WQKIISTPSS KDKFEKVLEE NKALDRFVRE 600
    REMPILNYQT IEVDGFKLNV LERRPPHFNE KKKYPVLFYQ YSGPGSQEVN 650
    KKFHVDFQAY IAANLEYIVV TVDGRGTGFL GRKLRCITRG NIGYYEAHDQ 700
    IAAAKIWASK KYVDADRLAI WGWSYGGFNT LKTLEQDAGQ TFKYGMAVAP 750
    VTDWRYYDSI YTERYMHTPQ NNAAGYNNST ITDVASLAKN TRFLLMHGVA 800
    DDNVHMQNTL TLLDRLDLAG VENYDVHVFP DSDHSIYFHN ANRIVYDKLR 850
    WWLINAFNGE WAKIKTAEPK AQVDARMERR 880
    Length:880
    Mass (Da):99,739
    Last modified:July 1, 2008 - v1
    Checksum:i2EBBF7438A194B42
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231622 Genomic DNA. Translation: EDU50464.1.
    RefSeqiXP_001937877.1. XM_001937842.1.

    Genome annotation databases

    EnsemblFungiiEDU50464; EDU50464; PTRG_07545.
    GeneIDi6345817.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231622 Genomic DNA. Translation: EDU50464.1 .
    RefSeqi XP_001937877.1. XM_001937842.1.

    3D structure databases

    ProteinModelPortali B2WC36.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EDU50464 ; EDU50464 ; PTRG_07545 .
    GeneIDi 6345817.

    Phylogenomic databases

    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-repentis, reveals transduplication and the impact of repeat elements on pathogenicity and population divergence."
      Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B., Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H., Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W., Schwartz D.C., Spatafora J.W.
      , Turgeon B.G., Yandava C., Young S., Zhou S., Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.
      G3 (Bethesda) 3:41-63(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pt-1C-BFP.

    Entry informationi

    Entry nameiDAPB_PYRTR
    AccessioniPrimary (citable) accession number: B2WC36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3