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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei724 – 7241Charge relay systemBy similarity
Active sitei801 – 8011Charge relay systemBy similarity
Active sitei834 – 8341Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:PTRG_07545
OrganismiPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Taxonomic identifieri426418 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora
ProteomesiUP000001471 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9393CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei94 – 11421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini115 – 880766VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 880880Probable dipeptidyl-aminopeptidase BPRO_0000412160Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi533 – 5331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi778 – 7781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB2WC36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiB2WC36.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B2WC36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRQRAPKEE EAELLTKQER SARSSEDASD TSISSISTTS LVLEHINDPA
60 70 80 90 100
INGTSRSRRG EKYTDEDDEA QEAFDVEGGR YKSPISVDKK TRRWLWIVGI
110 120 130 140 150
ACVTGWALAL VFFLMSGSYK HVSTRPHDPL ASSTKGSGKK ITMDDVFGGR
160 170 180 190 200
FYAREQSLKW IAGPNGEDGL LLERDAGNAE YLVVEDIRNK GDGDSSAKKT
210 220 230 240 250
KLMQKSGFNV NGYFVRPVEV WPSKDFKKTG EPLDPENQDG RVQLASLSPQ
260 270 280 290 300
SDAVVFTRNN NMYLRKLDSK EVIQITRDGG SELFYGIPDW VYEEEVFQTN
310 320 330 340 350
SATWWSEDGK YIAFLRTDES TVPTYPVQYF VSRPSGDKPK AGEENYPEVR
360 370 380 390 400
NIKYPKAGAP NPIVTLQFYD VEKAEVFSVE IEDDFRDNNR LITEIVWAGK
410 420 430 440 450
TKQVLVRETN RESDILKVVL MDVEKRTGKT VRTENVAELD GGWFEVSQKT
460 470 480 490 500
TFVPADPANG RKDDGYIDTI IHEGYDHIGY FTPLDNDKPI VLSQGEWEVV
510 520 530 540 550
DAPSRVDLKN NIVYYISTAK SSMERHAYSV FLNGTGTSEV VENSGSGYYG
560 570 580 590 600
ASFSAGGSYA LITYQGPGIP WQKIISTPSS KDKFEKVLEE NKALDRFVRE
610 620 630 640 650
REMPILNYQT IEVDGFKLNV LERRPPHFNE KKKYPVLFYQ YSGPGSQEVN
660 670 680 690 700
KKFHVDFQAY IAANLEYIVV TVDGRGTGFL GRKLRCITRG NIGYYEAHDQ
710 720 730 740 750
IAAAKIWASK KYVDADRLAI WGWSYGGFNT LKTLEQDAGQ TFKYGMAVAP
760 770 780 790 800
VTDWRYYDSI YTERYMHTPQ NNAAGYNNST ITDVASLAKN TRFLLMHGVA
810 820 830 840 850
DDNVHMQNTL TLLDRLDLAG VENYDVHVFP DSDHSIYFHN ANRIVYDKLR
860 870 880
WWLINAFNGE WAKIKTAEPK AQVDARMERR
Length:880
Mass (Da):99,739
Last modified:July 1, 2008 - v1
Checksum:i2EBBF7438A194B42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231622 Genomic DNA. Translation: EDU50464.1.
RefSeqiXP_001937877.1. XM_001937842.1.

Genome annotation databases

EnsemblFungiiEDU50464; EDU50464; PTRG_07545.
GeneIDi6345817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231622 Genomic DNA. Translation: EDU50464.1.
RefSeqiXP_001937877.1. XM_001937842.1.

3D structure databases

ProteinModelPortaliB2WC36.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS09.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEDU50464; EDU50464; PTRG_07545.
GeneIDi6345817.

Phylogenomic databases

InParanoidiB2WC36.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-repentis, reveals transduplication and the impact of repeat elements on pathogenicity and population divergence."
    Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B., Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H., Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W., Schwartz D.C., Spatafora J.W.
    , Turgeon B.G., Yandava C., Young S., Zhou S., Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.
    G3 (Bethesda) 3:41-63(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pt-1C-BFP.

Entry informationi

Entry nameiDAPB_PYRTR
AccessioniPrimary (citable) accession number: B2WC36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 1, 2008
Last modified: January 7, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.