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B2WC36 (DAPB_PYRTR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:dapB
ORF Names:PTRG_07545
OrganismPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis) [Complete proteome]
Taxonomic identifier426418 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora

Protein attributes

Sequence length880 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 880880Probable dipeptidyl-aminopeptidase B
PRO_0000412160

Regions

Topological domain1 – 9393Cytoplasmic Potential
Transmembrane94 – 11421Helical; Signal-anchor for type II membrane protein; Potential
Topological domain115 – 880766Vacuolar Potential

Sites

Active site7241Charge relay system By similarity
Active site8011Charge relay system By similarity
Active site8341Charge relay system By similarity

Amino acid modifications

Glycosylation5331N-linked (GlcNAc...) Potential
Glycosylation7781N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B2WC36 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 2EBBF7438A194B42

FASTA88099,739
        10         20         30         40         50         60 
MPRQRAPKEE EAELLTKQER SARSSEDASD TSISSISTTS LVLEHINDPA INGTSRSRRG 

        70         80         90        100        110        120 
EKYTDEDDEA QEAFDVEGGR YKSPISVDKK TRRWLWIVGI ACVTGWALAL VFFLMSGSYK 

       130        140        150        160        170        180 
HVSTRPHDPL ASSTKGSGKK ITMDDVFGGR FYAREQSLKW IAGPNGEDGL LLERDAGNAE 

       190        200        210        220        230        240 
YLVVEDIRNK GDGDSSAKKT KLMQKSGFNV NGYFVRPVEV WPSKDFKKTG EPLDPENQDG 

       250        260        270        280        290        300 
RVQLASLSPQ SDAVVFTRNN NMYLRKLDSK EVIQITRDGG SELFYGIPDW VYEEEVFQTN 

       310        320        330        340        350        360 
SATWWSEDGK YIAFLRTDES TVPTYPVQYF VSRPSGDKPK AGEENYPEVR NIKYPKAGAP 

       370        380        390        400        410        420 
NPIVTLQFYD VEKAEVFSVE IEDDFRDNNR LITEIVWAGK TKQVLVRETN RESDILKVVL 

       430        440        450        460        470        480 
MDVEKRTGKT VRTENVAELD GGWFEVSQKT TFVPADPANG RKDDGYIDTI IHEGYDHIGY 

       490        500        510        520        530        540 
FTPLDNDKPI VLSQGEWEVV DAPSRVDLKN NIVYYISTAK SSMERHAYSV FLNGTGTSEV 

       550        560        570        580        590        600 
VENSGSGYYG ASFSAGGSYA LITYQGPGIP WQKIISTPSS KDKFEKVLEE NKALDRFVRE 

       610        620        630        640        650        660 
REMPILNYQT IEVDGFKLNV LERRPPHFNE KKKYPVLFYQ YSGPGSQEVN KKFHVDFQAY 

       670        680        690        700        710        720 
IAANLEYIVV TVDGRGTGFL GRKLRCITRG NIGYYEAHDQ IAAAKIWASK KYVDADRLAI 

       730        740        750        760        770        780 
WGWSYGGFNT LKTLEQDAGQ TFKYGMAVAP VTDWRYYDSI YTERYMHTPQ NNAAGYNNST 

       790        800        810        820        830        840 
ITDVASLAKN TRFLLMHGVA DDNVHMQNTL TLLDRLDLAG VENYDVHVFP DSDHSIYFHN 

       850        860        870        880 
ANRIVYDKLR WWLINAFNGE WAKIKTAEPK AQVDARMERR 

« Hide

References

[1]"Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-repentis, reveals transduplication and the impact of repeat elements on pathogenicity and population divergence."
Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B., Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H., Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W., Schwartz D.C., Spatafora J.W. expand/collapse author list , Turgeon B.G., Yandava C., Young S., Zhou S., Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.
G3 (Bethesda) 3:41-63(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pt-1C-BFP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS231622 Genomic DNA. Translation: EDU50464.1.
RefSeqXP_001937877.1. XM_001937842.1.

3D structure databases

ProteinModelPortalB2WC36.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEDU50464; EDU50464; PTRG_07545.
GeneID6345817.

Phylogenomic databases

OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDAPB_PYRTR
AccessionPrimary (citable) accession number: B2WC36
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 1, 2008
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries