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B2WC36

- DAPB_PYRTR

UniProt

B2WC36 - DAPB_PYRTR

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Protein

Probable dipeptidyl-aminopeptidase B

Gene
dapB, PTRG_07545
Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei724 – 7241Charge relay system By similarity
Active sitei801 – 8011Charge relay system By similarity
Active sitei834 – 8341Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:PTRG_07545
OrganismiPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Taxonomic identifieri426418 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora
ProteomesiUP000001471: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9393Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei94 – 11421Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini115 – 880766Vacuolar Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 880880Probable dipeptidyl-aminopeptidase BPRO_0000412160Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi533 – 5331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi778 – 7781N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB2WC36.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B2WC36-1 [UniParc]FASTAAdd to Basket

« Hide

MPRQRAPKEE EAELLTKQER SARSSEDASD TSISSISTTS LVLEHINDPA    50
INGTSRSRRG EKYTDEDDEA QEAFDVEGGR YKSPISVDKK TRRWLWIVGI 100
ACVTGWALAL VFFLMSGSYK HVSTRPHDPL ASSTKGSGKK ITMDDVFGGR 150
FYAREQSLKW IAGPNGEDGL LLERDAGNAE YLVVEDIRNK GDGDSSAKKT 200
KLMQKSGFNV NGYFVRPVEV WPSKDFKKTG EPLDPENQDG RVQLASLSPQ 250
SDAVVFTRNN NMYLRKLDSK EVIQITRDGG SELFYGIPDW VYEEEVFQTN 300
SATWWSEDGK YIAFLRTDES TVPTYPVQYF VSRPSGDKPK AGEENYPEVR 350
NIKYPKAGAP NPIVTLQFYD VEKAEVFSVE IEDDFRDNNR LITEIVWAGK 400
TKQVLVRETN RESDILKVVL MDVEKRTGKT VRTENVAELD GGWFEVSQKT 450
TFVPADPANG RKDDGYIDTI IHEGYDHIGY FTPLDNDKPI VLSQGEWEVV 500
DAPSRVDLKN NIVYYISTAK SSMERHAYSV FLNGTGTSEV VENSGSGYYG 550
ASFSAGGSYA LITYQGPGIP WQKIISTPSS KDKFEKVLEE NKALDRFVRE 600
REMPILNYQT IEVDGFKLNV LERRPPHFNE KKKYPVLFYQ YSGPGSQEVN 650
KKFHVDFQAY IAANLEYIVV TVDGRGTGFL GRKLRCITRG NIGYYEAHDQ 700
IAAAKIWASK KYVDADRLAI WGWSYGGFNT LKTLEQDAGQ TFKYGMAVAP 750
VTDWRYYDSI YTERYMHTPQ NNAAGYNNST ITDVASLAKN TRFLLMHGVA 800
DDNVHMQNTL TLLDRLDLAG VENYDVHVFP DSDHSIYFHN ANRIVYDKLR 850
WWLINAFNGE WAKIKTAEPK AQVDARMERR 880
Length:880
Mass (Da):99,739
Last modified:July 1, 2008 - v1
Checksum:i2EBBF7438A194B42
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS231622 Genomic DNA. Translation: EDU50464.1.
RefSeqiXP_001937877.1. XM_001937842.1.

Genome annotation databases

EnsemblFungiiEDU50464; EDU50464; PTRG_07545.
GeneIDi6345817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS231622 Genomic DNA. Translation: EDU50464.1 .
RefSeqi XP_001937877.1. XM_001937842.1.

3D structure databases

ProteinModelPortali B2WC36.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EDU50464 ; EDU50464 ; PTRG_07545 .
GeneIDi 6345817.

Phylogenomic databases

OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-repentis, reveals transduplication and the impact of repeat elements on pathogenicity and population divergence."
    Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B., Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H., Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W., Schwartz D.C., Spatafora J.W.
    , Turgeon B.G., Yandava C., Young S., Zhou S., Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.
    G3 (Bethesda) 3:41-63(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pt-1C-BFP.

Entry informationi

Entry nameiDAPB_PYRTR
AccessioniPrimary (citable) accession number: B2WC36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 1, 2008
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3