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B2WAQ3 (LCPS_PYRTR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional lycopene cyclase/phytoene synthase

Including the following 2 domains:

  1. Lycopene beta-cyclase
    EC=5.5.1.19
    Alternative name(s):
    Lycopene cyclase
  2. Phytoene synthase
    EC=2.5.1.32
Gene names
ORF Names:PTRG_07366
OrganismPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis) [Complete proteome]
Taxonomic identifier426418 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora

Protein attributes

Sequence length583 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activity

Carotenoid psi-end group = carotenoid beta-end group.

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathway

Carotenoid biosynthesis; beta-carotene biosynthesis.

Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

In the N-terminal section; belongs to the lycopene beta-cyclase family.

In the C-terminal section; belongs to the phytoene/squalene synthase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 583583Bifunctional lycopene cyclase/phytoene synthase
PRO_0000409242

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane35 – 5521Helical; Potential
Transmembrane75 – 9723Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane173 – 19321Helical; Potential
Transmembrane221 – 24121Helical; Potential
Region1 – 243243Lycopene beta-cyclase
Region250 – 583334Phytoene synthase

Sequences

Sequence LengthMass (Da)Tools
B2WAQ3 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: F0851DA16FAE327E

FASTA58366,281
        10         20         30         40         50         60 
MGFDYALVHL KYTIPPAVLL TWLYRPFFTK LDVYKVGYLV SIAVASTIPW DSYLIRTGIW 

        70         80         90        100        110        120 
SYPTHVIIGP KLCDIPLEEV FFFIIQTYNT SLLYLLLSRP TFQPVYLNTE RGAARRQWRY 

       130        140        150        160        170        180 
MRLAGQVFFL ALIAWGWRCI RHGGLGTYTG LILVWAGPFL LMLWSLAYQF ILALPVTNTA 

       190        200        210        220        230        240 
LPIFLPTLYL WVVDTLALRR GTWVISTGTK YGLHLWDGLE IEEALFFLAT NALIVFGQLA 

       250        260        270        280        290        300 
FDNALAVLYT FPHLFTGPSL LPSPVLLMRA LLTPCSKYHD ARIKGLDEAV NRLKRKSRSF 

       310        320        330        340        350        360 
YLASATFPGP LRADLLLLYS FCRVADDLVD NASDADEARA WIAKMRKFLN NVYSDKLPQS 

       370        380        390        400        410        420 
VVHSQICDDF PPSTQSALLQ LPATKLSPQP LEDLLHGFEM DLAFQQGPII RTMEDLRVYS 

       430        440        450        460        470        480 
ERVAGTVAQM CIQLIFYWYP STLDTEEKNV IVAAGNSMGV ALQYVNIARD IEVDAQIGRV 

       490        500        510        520        530        540 
YLPLNWLSEA GLSYDDVLKK PNQAQIQTLR KHLLNHAFSV YEKAKDSIER LPIEARGPIR 

       550        560        570        580 
VAVESYMEIG RILRSEQYQV KAGRATVPKS RRIMVAWRTL NSK 

« Hide

References

[1]"Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-repentis, reveals transduplication and the impact of repeat elements on pathogenicity and population divergence."
Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B., Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H., Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W., Schwartz D.C., Spatafora J.W. expand/collapse author list , Turgeon B.G., Yandava C., Young S., Zhou S., Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.
G3 (Bethesda) 3:41-63(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pt-1C-BFP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS231621 Genomic DNA. Translation: EDU50285.1.
RefSeqXP_001937698.1. XM_001937663.1.

3D structure databases

ProteinModelPortalB2WAQ3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEDU50285; EDU50285; PTRG_07366.
GeneID6345639.

Phylogenomic databases

OrthoDBEOG7RBZJ2.

Enzyme and pathway databases

UniPathwayUPA00799; UER00773.
UPA00802.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR03462. CarR_dom_SF. 2 hits.
PROSITEPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLCPS_PYRTR
AccessionPrimary (citable) accession number: B2WAQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways