Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B2WAQ3

- LCPS_PYRTR

UniProt

B2WAQ3 - LCPS_PYRTR

Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

PTRG_07366

Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

    Catalytic activityi

    Carotenoid psi-end group = carotenoid beta-end group.
    2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

    Pathwayi

    GO - Molecular functioni

    1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
    2. intramolecular lyase activity Source: InterPro

    GO - Biological processi

    1. carotenoid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Transferase

    Keywords - Biological processi

    Carotenoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00799; UER00773.
    UPA00802.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional lycopene cyclase/phytoene synthase
    Including the following 2 domains:
    Lycopene beta-cyclase (EC:5.5.1.19)
    Alternative name(s):
    Lycopene cyclase
    Phytoene synthase (EC:2.5.1.32)
    Gene namesi
    ORF Names:PTRG_07366
    OrganismiPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
    Taxonomic identifieri426418 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora
    ProteomesiUP000001471: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 583583Bifunctional lycopene cyclase/phytoene synthasePRO_0000409242Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliB2WAQ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei75 – 9723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 243243Lycopene beta-cyclaseAdd
    BLAST
    Regioni250 – 583334Phytoene synthaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
    In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG7RBZJ2.

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR017825. Lycopene_cyclase_dom.
    IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00494. SQS_PSY. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
    PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2WAQ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFDYALVHL KYTIPPAVLL TWLYRPFFTK LDVYKVGYLV SIAVASTIPW    50
    DSYLIRTGIW SYPTHVIIGP KLCDIPLEEV FFFIIQTYNT SLLYLLLSRP 100
    TFQPVYLNTE RGAARRQWRY MRLAGQVFFL ALIAWGWRCI RHGGLGTYTG 150
    LILVWAGPFL LMLWSLAYQF ILALPVTNTA LPIFLPTLYL WVVDTLALRR 200
    GTWVISTGTK YGLHLWDGLE IEEALFFLAT NALIVFGQLA FDNALAVLYT 250
    FPHLFTGPSL LPSPVLLMRA LLTPCSKYHD ARIKGLDEAV NRLKRKSRSF 300
    YLASATFPGP LRADLLLLYS FCRVADDLVD NASDADEARA WIAKMRKFLN 350
    NVYSDKLPQS VVHSQICDDF PPSTQSALLQ LPATKLSPQP LEDLLHGFEM 400
    DLAFQQGPII RTMEDLRVYS ERVAGTVAQM CIQLIFYWYP STLDTEEKNV 450
    IVAAGNSMGV ALQYVNIARD IEVDAQIGRV YLPLNWLSEA GLSYDDVLKK 500
    PNQAQIQTLR KHLLNHAFSV YEKAKDSIER LPIEARGPIR VAVESYMEIG 550
    RILRSEQYQV KAGRATVPKS RRIMVAWRTL NSK 583
    Length:583
    Mass (Da):66,281
    Last modified:July 1, 2008 - v1
    Checksum:iF0851DA16FAE327E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231621 Genomic DNA. Translation: EDU50285.1.
    RefSeqiXP_001937698.1. XM_001937663.1.

    Genome annotation databases

    EnsemblFungiiEDU50285; EDU50285; PTRG_07366.
    GeneIDi6345639.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231621 Genomic DNA. Translation: EDU50285.1 .
    RefSeqi XP_001937698.1. XM_001937663.1.

    3D structure databases

    ProteinModelPortali B2WAQ3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EDU50285 ; EDU50285 ; PTRG_07366 .
    GeneIDi 6345639.

    Phylogenomic databases

    OrthoDBi EOG7RBZJ2.

    Enzyme and pathway databases

    UniPathwayi UPA00799 ; UER00773 .
    UPA00802 .

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR017825. Lycopene_cyclase_dom.
    IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00494. SQS_PSY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
    PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-repentis, reveals transduplication and the impact of repeat elements on pathogenicity and population divergence."
      Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B., Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H., Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W., Schwartz D.C., Spatafora J.W.
      , Turgeon B.G., Yandava C., Young S., Zhou S., Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.
      G3 (Bethesda) 3:41-63(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pt-1C-BFP.

    Entry informationi

    Entry nameiLCPS_PYRTR
    AccessioniPrimary (citable) accession number: B2WAQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 31, 2011
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3