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B2WAQ3

- LCPS_PYRTR

UniProt

B2WAQ3 - LCPS_PYRTR

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Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

PTRG_07366

Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
  2. intramolecular lyase activity Source: InterPro

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
ORF Names:PTRG_07366
OrganismiPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Taxonomic identifieri426418 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora
ProteomesiUP000001471: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence AnalysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Transmembranei75 – 9723HelicalSequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 583583Bifunctional lycopene cyclase/phytoene synthasePRO_0000409242Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB2WAQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 243243Lycopene beta-cyclaseAdd
BLAST
Regioni250 – 583334Phytoene synthaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiB2WAQ3.
OrthoDBiEOG7RBZJ2.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2WAQ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGFDYALVHL KYTIPPAVLL TWLYRPFFTK LDVYKVGYLV SIAVASTIPW
60 70 80 90 100
DSYLIRTGIW SYPTHVIIGP KLCDIPLEEV FFFIIQTYNT SLLYLLLSRP
110 120 130 140 150
TFQPVYLNTE RGAARRQWRY MRLAGQVFFL ALIAWGWRCI RHGGLGTYTG
160 170 180 190 200
LILVWAGPFL LMLWSLAYQF ILALPVTNTA LPIFLPTLYL WVVDTLALRR
210 220 230 240 250
GTWVISTGTK YGLHLWDGLE IEEALFFLAT NALIVFGQLA FDNALAVLYT
260 270 280 290 300
FPHLFTGPSL LPSPVLLMRA LLTPCSKYHD ARIKGLDEAV NRLKRKSRSF
310 320 330 340 350
YLASATFPGP LRADLLLLYS FCRVADDLVD NASDADEARA WIAKMRKFLN
360 370 380 390 400
NVYSDKLPQS VVHSQICDDF PPSTQSALLQ LPATKLSPQP LEDLLHGFEM
410 420 430 440 450
DLAFQQGPII RTMEDLRVYS ERVAGTVAQM CIQLIFYWYP STLDTEEKNV
460 470 480 490 500
IVAAGNSMGV ALQYVNIARD IEVDAQIGRV YLPLNWLSEA GLSYDDVLKK
510 520 530 540 550
PNQAQIQTLR KHLLNHAFSV YEKAKDSIER LPIEARGPIR VAVESYMEIG
560 570 580
RILRSEQYQV KAGRATVPKS RRIMVAWRTL NSK
Length:583
Mass (Da):66,281
Last modified:July 1, 2008 - v1
Checksum:iF0851DA16FAE327E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231621 Genomic DNA. Translation: EDU50285.1.
RefSeqiXP_001937698.1. XM_001937663.1.

Genome annotation databases

EnsemblFungiiEDU50285; EDU50285; PTRG_07366.
GeneIDi6345639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231621 Genomic DNA. Translation: EDU50285.1 .
RefSeqi XP_001937698.1. XM_001937663.1.

3D structure databases

ProteinModelPortali B2WAQ3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EDU50285 ; EDU50285 ; PTRG_07366 .
GeneIDi 6345639.

Phylogenomic databases

InParanoidi B2WAQ3.
OrthoDBi EOG7RBZJ2.

Enzyme and pathway databases

UniPathwayi UPA00799 ; UER00773 .
UPA00802 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-repentis, reveals transduplication and the impact of repeat elements on pathogenicity and population divergence."
    Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B., Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H., Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W., Schwartz D.C., Spatafora J.W.
    , Turgeon B.G., Yandava C., Young S., Zhou S., Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.
    G3 (Bethesda) 3:41-63(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pt-1C-BFP.

Entry informationi

Entry nameiLCPS_PYRTR
AccessioniPrimary (citable) accession number: B2WAQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3