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B2W791

- BGALB_PYRTR

UniProt

B2W791 - BGALB_PYRTR

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Protein

Probable beta-galactosidase B

Gene

lacB

Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961SubstrateBy similarity
Binding sitei141 – 1411SubstrateBy similarity
Binding sitei142 – 1421Substrate; via amide nitrogenBy similarity
Binding sitei143 – 1431SubstrateBy similarity
Binding sitei201 – 2011SubstrateBy similarity
Active sitei202 – 2021Proton donorSequence Analysis
Binding sitei271 – 2711SubstrateBy similarity
Active sitei314 – 3141NucleophileSequence Analysis
Binding sitei379 – 3791SubstrateBy similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase B (EC:3.2.1.23)
Alternative name(s):
Lactase B
Gene namesi
Name:lacB
ORF Names:PTRG_05679
OrganismiPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Taxonomic identifieri426418 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora
ProteomesiUP000001471: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 1009982Probable beta-galactosidase BPRO_0000395232Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi277 ↔ 330By similarity
Glycosylationi467 – 4671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi495 – 4951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi593 – 5931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi632 – 6321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi672 – 6721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi707 – 7071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi775 – 7751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi782 – 7821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi789 – 7891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi795 – 7951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi914 – 9141N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB2W791.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiB2W791.
OrthoDBiEOG7ZGXBD.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2W791-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTIAGLSWI SALSSLASLP NGLGVSAQNN TPSTWPLHDN GLSDVVQWDH
60 70 80 90 100
YSFKVNGKRL FVFSGEIHYW RIPVYEVWED LLEKIKAAGF TAFAFYGNWA
110 120 130 140 150
YHSANNKTLD FESGAHDFSK LFEIAHRVGL YVITRPGPYV NAEANAGGFP
160 170 180 190 200
LWLTTGAYGK LRDDDPRYLQ ALDPYFSKFS ELTSKHLVTN GGNALVYQIE
210 220 230 240 250
NEYGEQWKDR TKKIPNDAAG RYMQALEDSA RANGIEIPLI HNDPNMNTKS
260 270 280 290 300
WSKDYAPGAV GNVDVAGLDS YPSCWSCNLA ECTGTNGKYV AYQVVNYYDH
310 320 330 340 350
FKEVSPTQPS FFPEFQGGSY NPWGGPEGGC PGDIGADFAN LFYRNLISQR
360 370 380 390 400
VTAVSLYMMF GGTNWGAIAA PVTATSYDYS SPISENREIG AKFYETKNLA
410 420 430 440 450
MFTRVADDLT VTDRLGSSSS YTTNPAVTAS ELRNPITKAA FYVTIHSVSS
460 470 480 490 500
SSTTESFKLH ISTSVGNLTI PQHSGSIVLN GHQSKIISTD FAMGNKTLTY
510 520 530 540 550
STAEILTYAL IDSSPVVVLS TDVGGSVEFH VKGATKGSLA SSGFTSNATF
560 570 580 590 600
RAEAGGVTTN IERVTGMGVY QFNNGVKVVL ADKPTAYLFW APNLSNDPFA
610 620 630 640 650
PVDQSVLIQG PYLVRGAALD GDVVALKGDV KNSTTIEVFA HETALTLSWN
660 670 680 690 700
GKKLETSRTP YGSLKAQISA FNGTIPLPSL NDWKVNEGLP EKMPEYDDNG
710 720 730 740 750
AAWVVANHTT TPNPTKPDTL PVLYVDEYGF HNSFHLFRGY FEGSATGAQL
760 770 780 790 800
SVQGGLAFGW SAWLNGDLVG SWLGNTTLGV GNMTLSFANA TVHANGTNVL
810 820 830 840 850
LIAQDNTGHD LRGGATDPRG ILRATLDGAD FTSWKIAGEA GGENIQLDPV
860 870 880 890 900
RGPLAEGGLT AERLGWHLSG FSDCDWASAS PSTGFSGADI KFYRTTFPLD
910 920 930 940 950
IPEDVDASFA FILNATGPKT VRVQLFVNGY QYARFNPYVG NEVKFPIPPG
960 970 980 990 1000
ILNYAGDNVI GLSVWAQGND GAKVDVEFVQ EYAVESSWSS RFDSEYLRPE

WTEERLAYA
Length:1,009
Mass (Da):109,564
Last modified:July 1, 2008 - v1
Checksum:i572EAEC64D06F663
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231619 Genomic DNA. Translation: EDU48599.1.
RefSeqiXP_001936012.1. XM_001935977.1.

Genome annotation databases

EnsemblFungiiEDU48599; EDU48599; PTRG_05679.
GeneIDi6343933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231619 Genomic DNA. Translation: EDU48599.1 .
RefSeqi XP_001936012.1. XM_001935977.1.

3D structure databases

ProteinModelPortali B2W791.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EDU48599 ; EDU48599 ; PTRG_05679 .
GeneIDi 6343933.

Phylogenomic databases

InParanoidi B2W791.
OrthoDBi EOG7ZGXBD.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-repentis, reveals transduplication and the impact of repeat elements on pathogenicity and population divergence."
    Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B., Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H., Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W., Schwartz D.C., Spatafora J.W.
    , Turgeon B.G., Yandava C., Young S., Zhou S., Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.
    G3 (Bethesda) 3:41-63(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pt-1C-BFP.

Entry informationi

Entry nameiBGALB_PYRTR
AccessioniPrimary (citable) accession number: B2W791
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3