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B2W340 (KEX1_PYRTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase kex1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:kex1
ORF Names:PTRG_03838
OrganismPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis) [Complete proteome]
Taxonomic identifier426418 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora

Protein attributes

Sequence length639 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 639609Pheromone-processing carboxypeptidase kex1
PRO_0000411943

Regions

Topological domain31 – 517487Lumenal Potential
Transmembrane518 – 53821Helical; Potential
Topological domain539 – 639101Cytoplasmic Potential

Sites

Active site1831 By similarity
Active site3841 By similarity
Active site4461 By similarity

Amino acid modifications

Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation4351N-linked (GlcNAc...) Potential
Glycosylation4431N-linked (GlcNAc...) Potential
Glycosylation4951N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B2W340 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 7F261923AB81FA5A

FASTA63971,619
        10         20         30         40         50         60 
MAFSHAPSGW RTALLAGLIA TVAWLPAIVA QEKTQADYFI HDLPGAPKPL LKMHAGHIEV 

        70         80         90        100        110        120 
DAEHNGNLFF WHYQNRHIAD RQRTVLWLNG GPGCSSMDGA MMEIGPYRVR EGGKLEYNNG 

       130        140        150        160        170        180 
SWDEFANLLF VDQPVGTGFS YVNTDSYLTE LDQMAAHMVI FLEKWFALFP EYENDDLYIA 

       190        200        210        220        230        240 
GESYAGQHIP YIARAILDRN KKNQAKSPWP LKGLLIGNGW MSPVDQYLSY IPFAYQNGLM 

       250        260        270        280        290        300 
RSGTDMAKRV EEQQRICVQK LEAGGMDAVD TRDCEQIMVR ILQETKNENA DPMNQCLNMY 

       310        320        330        340        350        360 
DIRLRDDSSC GMNWPPDLAQ VTPYLRRADV VQALHINTDK KTGWQECNGA VSSHFRAKNS 

       370        380        390        400        410        420 
KPSVKFLPEV IEQVPVLLFS GDKDFICNHV GTEAMIQNLQ WNGGKGFEAS PGVQNAKQDW 

       430        440        450        460        470        480 
MFEGEAAGTW QEARNLTYVV FYNSSHMVPF DYPRRTRDML DRFMGVNIEA IGGAPADSLI 

       490        500        510        520        530        540 
DGEKGPLTSV GDHPNSTKAE EDKSKELKAA EWKAYTRSGE VALVIAVIVA CICGFLLCRS 

       550        560        570        580        590        600 
RRAKSAYKGD DSDEGRESLL TGMGLDNFRR KERRQDVEAA DFDERELDEV PKKSGKGYGQ 

       610        620        630 
ISSEKGRVPH NDSSFSLGVD SDDDEAGSSD RGRRKEESR 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS231617 Genomic DNA. Translation: EDU46676.1.
RefSeqXP_001934171.1. XM_001934136.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEDU46676; EDU46676; PTRG_03838.
GeneID6342074.

Phylogenomic databases

OrthoDBEOG7TJ3SJ.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_PYRTR
AccessionPrimary (citable) accession number: B2W340
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 1, 2008
Last modified: February 19, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries