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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei183 – 1831PROSITE-ProRule annotation
Active sitei384 – 3841PROSITE-ProRule annotation
Active sitei446 – 4461PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:PTRG_03838
OrganismiPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Taxonomic identifieri426418 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora
ProteomesiUP000001471 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 517487LumenalSequence AnalysisAdd
BLAST
Transmembranei518 – 53821HelicalSequence AnalysisAdd
BLAST
Topological domaini539 – 639101CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 639609Pheromone-processing carboxypeptidase kex1PRO_0000411943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi495 – 4951N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi426418.XP_001934171.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiB2W340.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2W340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFSHAPSGW RTALLAGLIA TVAWLPAIVA QEKTQADYFI HDLPGAPKPL
60 70 80 90 100
LKMHAGHIEV DAEHNGNLFF WHYQNRHIAD RQRTVLWLNG GPGCSSMDGA
110 120 130 140 150
MMEIGPYRVR EGGKLEYNNG SWDEFANLLF VDQPVGTGFS YVNTDSYLTE
160 170 180 190 200
LDQMAAHMVI FLEKWFALFP EYENDDLYIA GESYAGQHIP YIARAILDRN
210 220 230 240 250
KKNQAKSPWP LKGLLIGNGW MSPVDQYLSY IPFAYQNGLM RSGTDMAKRV
260 270 280 290 300
EEQQRICVQK LEAGGMDAVD TRDCEQIMVR ILQETKNENA DPMNQCLNMY
310 320 330 340 350
DIRLRDDSSC GMNWPPDLAQ VTPYLRRADV VQALHINTDK KTGWQECNGA
360 370 380 390 400
VSSHFRAKNS KPSVKFLPEV IEQVPVLLFS GDKDFICNHV GTEAMIQNLQ
410 420 430 440 450
WNGGKGFEAS PGVQNAKQDW MFEGEAAGTW QEARNLTYVV FYNSSHMVPF
460 470 480 490 500
DYPRRTRDML DRFMGVNIEA IGGAPADSLI DGEKGPLTSV GDHPNSTKAE
510 520 530 540 550
EDKSKELKAA EWKAYTRSGE VALVIAVIVA CICGFLLCRS RRAKSAYKGD
560 570 580 590 600
DSDEGRESLL TGMGLDNFRR KERRQDVEAA DFDERELDEV PKKSGKGYGQ
610 620 630
ISSEKGRVPH NDSSFSLGVD SDDDEAGSSD RGRRKEESR
Length:639
Mass (Da):71,619
Last modified:July 1, 2008 - v1
Checksum:i7F261923AB81FA5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231617 Genomic DNA. Translation: EDU46676.1.
RefSeqiXP_001934171.1. XM_001934136.1.

Genome annotation databases

EnsemblFungiiEDU46676; EDU46676; PTRG_03838.
GeneIDi6342074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231617 Genomic DNA. Translation: EDU46676.1.
RefSeqiXP_001934171.1. XM_001934136.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi426418.XP_001934171.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEDU46676; EDU46676; PTRG_03838.
GeneIDi6342074.

Phylogenomic databases

InParanoidiB2W340.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-repentis, reveals transduplication and the impact of repeat elements on pathogenicity and population divergence."
    Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B., Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H., Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W., Schwartz D.C., Spatafora J.W.
    , Turgeon B.G., Yandava C., Young S., Zhou S., Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.
    G3 (Bethesda) 3:41-63(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pt-1C-BFP.

Entry informationi

Entry nameiKEX1_PYRTR
AccessioniPrimary (citable) accession number: B2W340
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 1, 2008
Last modified: June 24, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.