Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B2W2N2 (M2DH_PYRTR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannitol 2-dehydrogenase

Short name=M2DH
Short name=MDH
EC=1.1.1.67
Gene names
ORF Names:PTRG_03680
OrganismPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis) [Complete proteome]
Taxonomic identifier426418 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora

Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway By similarity.

Catalytic activity

D-mannitol + NAD+ = D-fructose + NADH.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol 2-dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 566566Mannitol 2-dehydrogenase
PRO_0000371548

Regions

Nucleotide binding106 – 11712NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B2W2N2 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 66AE6016BDE2FFA3

FASTA56662,728
        10         20         30         40         50         60 
MPPQVARNLL RAARARAVFQ STRPAHRRPA AISCRFQSTE AVRQTPSDVY QAPPRGFVPR 

        70         80         90        100        110        120 
KEEKFVPTQS RKAAPAATLK LNSKNLSSLQ NVSVPTYKRH GVKQGIVHVG VGGFHRAHLA 

       130        140        150        160        170        180 
AYVDTLLEQF NVQDWSICGV DLQPFAAPMR DALKPQDNLY TMIERAADGT SARVIGSITD 

       190        200        210        220        230        240 
YLFAPDSAEA VIAKMAHPDT HIVSMTVTES GYYMNENTHE LQIDHPDVAA DLAGEQPART 

       250        260        270        280        290        300 
VFGYLYAAMA RRHAAGLRPF TVLSCDNMQK NGDISRNMLV SFARHAGNNE VADWIASNGA 

       310        320        330        340        350        360 
FPNSMVDRIT PRTNDEDKVS LAKNFGVEDA WPVVTEPFHQ WVLEDKFVDG RPPFEKAGVQ 

       370        380        390        400        410        420 
IVPDVHQVEE YEMIKLRLLN GSHSAMGYAG QLAGFTYIHE VISHPVYRQF VINMMQQEVK 

       430        440        450        460        470        480 
PLLPQIPGVS VDDYCNTLLG RFSNPTLKDE LPRICLGGSG KIPQFIMPSI AEQIIAGGPL 

       490        500        510        520        530        540 
RRLTLVAAAW FRYNKGIDDA GNAFKVDDPM VEELQAKAAE GPIAQLQIKN LFGDDLRQDK 

       550        560 
RFVQELKTAL EGLEREGALA MIEKYA 

« Hide

References

[1]"Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-repentis, reveals transduplication and the impact of repeat elements on pathogenicity and population divergence."
Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B., Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H., Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W., Schwartz D.C., Spatafora J.W. expand/collapse author list , Turgeon B.G., Yandava C., Young S., Zhou S., Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.
G3 (Bethesda) 3:41-63(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pt-1C-BFP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS231617 Genomic DNA. Translation: EDU46518.1.
RefSeqXP_001934013.1. XM_001933978.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEDU46518; EDU46518; PTRG_03680.
GeneID6341912.

Phylogenomic databases

OrthoDBEOG7PCJRT.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
ProtoNetSearch...

Entry information

Entry nameM2DH_PYRTR
AccessionPrimary (citable) accession number: B2W2N2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families