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Protein

Mannitol 2-dehydrogenase

Gene

PTRG_03680

Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.By similarity

Catalytic activityi

D-mannitol + NAD+ = D-fructose + NADH.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi106 – 117NADBy similarityAdd BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Mannitol 2-dehydrogenase (EC:1.1.1.67)
Short name:
M2DH
Short name:
MDH
Gene namesi
ORF Names:PTRG_03680
OrganismiPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Taxonomic identifieri426418 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora
Proteomesi
  • UP000001471 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003715481 – 566Mannitol 2-dehydrogenaseAdd BLAST566

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi426418.XP_001934013.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the mannitol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG410IE1G. Eukaryota.
COG0246. LUCA.
InParanoidiB2W2N2.
OrthoDBiEOG092C1JOH.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

B2W2N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPQVARNLL RAARARAVFQ STRPAHRRPA AISCRFQSTE AVRQTPSDVY
60 70 80 90 100
QAPPRGFVPR KEEKFVPTQS RKAAPAATLK LNSKNLSSLQ NVSVPTYKRH
110 120 130 140 150
GVKQGIVHVG VGGFHRAHLA AYVDTLLEQF NVQDWSICGV DLQPFAAPMR
160 170 180 190 200
DALKPQDNLY TMIERAADGT SARVIGSITD YLFAPDSAEA VIAKMAHPDT
210 220 230 240 250
HIVSMTVTES GYYMNENTHE LQIDHPDVAA DLAGEQPART VFGYLYAAMA
260 270 280 290 300
RRHAAGLRPF TVLSCDNMQK NGDISRNMLV SFARHAGNNE VADWIASNGA
310 320 330 340 350
FPNSMVDRIT PRTNDEDKVS LAKNFGVEDA WPVVTEPFHQ WVLEDKFVDG
360 370 380 390 400
RPPFEKAGVQ IVPDVHQVEE YEMIKLRLLN GSHSAMGYAG QLAGFTYIHE
410 420 430 440 450
VISHPVYRQF VINMMQQEVK PLLPQIPGVS VDDYCNTLLG RFSNPTLKDE
460 470 480 490 500
LPRICLGGSG KIPQFIMPSI AEQIIAGGPL RRLTLVAAAW FRYNKGIDDA
510 520 530 540 550
GNAFKVDDPM VEELQAKAAE GPIAQLQIKN LFGDDLRQDK RFVQELKTAL
560
EGLEREGALA MIEKYA
Length:566
Mass (Da):62,728
Last modified:July 1, 2008 - v1
Checksum:i66AE6016BDE2FFA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231617 Genomic DNA. Translation: EDU46518.1.
RefSeqiXP_001934013.1. XM_001933978.1.

Genome annotation databases

EnsemblFungiiEDU46518; EDU46518; PTRG_03680.
GeneIDi6341912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231617 Genomic DNA. Translation: EDU46518.1.
RefSeqiXP_001934013.1. XM_001933978.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi426418.XP_001934013.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEDU46518; EDU46518; PTRG_03680.
GeneIDi6341912.

Phylogenomic databases

eggNOGiENOG410IE1G. Eukaryota.
COG0246. LUCA.
InParanoidiB2W2N2.
OrthoDBiEOG092C1JOH.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiM2DH_PYRTR
AccessioniPrimary (citable) accession number: B2W2N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 1, 2008
Last modified: September 7, 2016
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.