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B2W2N2

- M2DH_PYRTR

UniProt

B2W2N2 - M2DH_PYRTR

Protein

Mannitol 2-dehydrogenase

Gene

PTRG_03680

Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.By similarity

    Catalytic activityi

    D-mannitol + NAD+ = D-fructose + NADH.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi106 – 11712NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. mannitol 2-dehydrogenase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannitol 2-dehydrogenase (EC:1.1.1.67)
    Short name:
    M2DH
    Short name:
    MDH
    Gene namesi
    ORF Names:PTRG_03680
    OrganismiPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
    Taxonomic identifieri426418 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora
    ProteomesiUP000001471: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 566566Mannitol 2-dehydrogenasePRO_0000371548Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mannitol dehydrogenase family.Curated

    Phylogenomic databases

    OrthoDBiEOG7PCJRT.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view]
    PRINTSiPR00084. MTLDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2W2N2-1 [UniParc]FASTAAdd to Basket

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    MPPQVARNLL RAARARAVFQ STRPAHRRPA AISCRFQSTE AVRQTPSDVY    50
    QAPPRGFVPR KEEKFVPTQS RKAAPAATLK LNSKNLSSLQ NVSVPTYKRH 100
    GVKQGIVHVG VGGFHRAHLA AYVDTLLEQF NVQDWSICGV DLQPFAAPMR 150
    DALKPQDNLY TMIERAADGT SARVIGSITD YLFAPDSAEA VIAKMAHPDT 200
    HIVSMTVTES GYYMNENTHE LQIDHPDVAA DLAGEQPART VFGYLYAAMA 250
    RRHAAGLRPF TVLSCDNMQK NGDISRNMLV SFARHAGNNE VADWIASNGA 300
    FPNSMVDRIT PRTNDEDKVS LAKNFGVEDA WPVVTEPFHQ WVLEDKFVDG 350
    RPPFEKAGVQ IVPDVHQVEE YEMIKLRLLN GSHSAMGYAG QLAGFTYIHE 400
    VISHPVYRQF VINMMQQEVK PLLPQIPGVS VDDYCNTLLG RFSNPTLKDE 450
    LPRICLGGSG KIPQFIMPSI AEQIIAGGPL RRLTLVAAAW FRYNKGIDDA 500
    GNAFKVDDPM VEELQAKAAE GPIAQLQIKN LFGDDLRQDK RFVQELKTAL 550
    EGLEREGALA MIEKYA 566
    Length:566
    Mass (Da):62,728
    Last modified:July 1, 2008 - v1
    Checksum:i66AE6016BDE2FFA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231617 Genomic DNA. Translation: EDU46518.1.
    RefSeqiXP_001934013.1. XM_001933978.1.

    Genome annotation databases

    EnsemblFungiiEDU46518; EDU46518; PTRG_03680.
    GeneIDi6341912.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS231617 Genomic DNA. Translation: EDU46518.1 .
    RefSeqi XP_001934013.1. XM_001933978.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EDU46518 ; EDU46518 ; PTRG_03680 .
    GeneIDi 6341912.

    Phylogenomic databases

    OrthoDBi EOG7PCJRT.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00084. MTLDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-repentis, reveals transduplication and the impact of repeat elements on pathogenicity and population divergence."
      Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B., Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H., Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W., Schwartz D.C., Spatafora J.W.
      , Turgeon B.G., Yandava C., Young S., Zhou S., Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.
      G3 (Bethesda) 3:41-63(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pt-1C-BFP.

    Entry informationi

    Entry nameiM2DH_PYRTR
    AccessioniPrimary (citable) accession number: B2W2N2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3