Reviewed, UniProtKB/Swiss-Prot B2W0K4 (KAD1_PYRTR)

Names and origin

Protein names

Recommended name:
    Adenylate kinase 1
      Short name=AK 1
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 1
    Adenylate kinase cytosolic and mitochondrial

Gene names

Name:	adk1
ORF Names:	PTRG_03989

Organism

Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)

Taxonomic identifier

426418 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporaceae › Pyrenophora

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.
Sequence caution	The sequence EDU46827.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Adenylate kinase 1		PRO_0000365686
Regions
	Nucleotide binding	49 – 57	9	ATP By similarity
	Nucleotide binding	72 – 101	30	AMP By similarity
Sites
	Binding site	73	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2W0K4-1 [UniParc]. Last modified March 3, 2009. Version 2. Checksum: B1F60A68FEFF8FEE	FASTA	276	29,967
	10 20 30 40 50 60 MAPMADSSVD DLKNDVKRLE QRIAELESRL AGHGGVAAAT ESVRMILMGP PGAGKGTQAP 70 80 90 100 110 120 RIKEKFCACH LATGDMLRAQ VAAKTPLGRE AKKIMDAGGL VSDEIMVNMI KTELENNQEC 130 140 150 160 170 180 ARGFILDGFP RTVTQAEKLD GMLAATKKPL QHAVELQIDD GLLVSRITGR LVHPASGRSY 190 200 210 220 230 240 HKIFNPPKAP MTDDVTGEPL IQRSDDNAET LKKRLSTYHA QTAPVVAYYQ KTGIWKPIDA 250 260 270 SQEPGQVWKS LLKIFDDKAM VAGRSGSLLN KIGLKN

References

[1]

"Genome sequence of Pyrenophora tritici-repentis." Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., MacCallum I.A., Young S.K., LaButti K., DeCaprio D. , Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., White J., Yandava C., Kodira C.D., Guigo R., Borodovsky M., Zeng Q., O'Leary S., Alvarado L., Pandelova I., Ciuffetti L. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS231617 Genomic DNA. Translation: EDU46827.1. Sequence problems.
RefSeq	XP_001934322.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6342225.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD1_PYRTR

Accession

Primary (citable) accession number: B2W0K4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	February 9, 2010
This is version 12 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)