B2VUU7 (AMPP1_PYRTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	ampp
ORF Names:	PTRG_01084

Organism

Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis) [Complete proteome]

Taxonomic identifier

426418 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › dothideomyceta › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporineae › Pleosporaceae › Pyrenophora › Pyrenophora tritici-repentis

Protein attributes

Sequence length	594 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 594	594	Probable Xaa-Pro aminopeptidase P		PRO_0000411807
Sites
	Metal binding	391	1	Manganese 2 By similarity
	Metal binding	402	1	Manganese 1 By similarity
	Metal binding	402	1	Manganese 2 By similarity
	Metal binding	500	1	Manganese 1 By similarity
	Metal binding	514	1	Manganese 1 By similarity
	Metal binding	514	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2VUU7 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: A1FAEF86BA116F09	FASTA	594	66,842
	10 20 30 40 50 60 MAKVDTSHRL AELRKLMKER NVDIYTYISG FTGSAGYAVI THDKAALSTD GRYFNQAEKQ 70 80 90 100 110 120 LDSNWELLKQ GIQDVPTIQE WTADQAEGGK VVGVDPSVVT AGDARKLAEK IKKKGGEYKA 130 140 150 160 170 180 IDENLVDLVW SSERPARPSE KVIVQPERYA CKGFEDKIDD LRKELEKKKS LGFVVSMLDE 190 200 210 220 230 240 VAWLFNLRGS DIPYNPVFFS YAVVTPTAAT LYVDENKLPE DVKEHLGNKI TIRPYEAIFG 250 260 270 280 290 300 DVTALSKELF EASDKNETQK KFLTSNRASW ALNKALGGDD KVEETRSPVG DSKAVKNEVE 310 320 330 340 350 360 LEGMRQCHIR DGAALSEYFA WLEDQLINKK ATLDEVDGAD KLEEIRKKHD MFMGLSFDTI 370 380 390 400 410 420 SSTGANAAVI HYKPEKGECA TIDPKAIYLC DSGAQYRDGT TDTTRTLHFT EPTEMERKAY 430 440 450 460 470 480 TLVLKGNMAL ERVKFPKGTT GFALDALARQ FLWAEGLDYR HGTGHGVGSF LNVHEGPIGI 490 500 510 520 530 540 GTRVQYSEVS LAVGNVVSDE PGYYEDGKFG IRIENMVMVK EVETKHKFGD KPYLGFEHVT 550 560 570 580 590 MTPHCRNLVD MSLLTEDEKK FINEYHKEVY EKTSKYFEND ALTLEWLKRE TAPY

References

[1]

"Genome sequence of Pyrenophora tritici-repentis." Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., MacCallum I.A., Young S.K., LaButti K., DeCaprio D. , Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., White J., Yandava C., Kodira C.D., Guigo R., Borodovsky M., Zeng Q., O'Leary S., Alvarado L., Pandelova I., Ciuffetti L. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pt-1C-BFP.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS231615 Genomic DNA. Translation: EDU40522.1.
RefSeq	XP_001931417.1. XM_001931382.1.
3D structure databases
ProteinModelPortal	B2VUU7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EDU40522; EDU40522; PTRG_01084.
GeneID	6338674.
Phylogenomic databases
OrthoDB	EOG45F0XX.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_PYRTR

Accession

Primary (citable) accession number: B2VUU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	July 1, 2008
Last modified:	May 29, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program