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Protein

Mitochondrial glycine transporter

Gene

PTRG_00728

Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:PTRG_00728
OrganismiPyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)
Taxonomic identifieri426418 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaePyrenophora
Proteomesi
  • UP000001471 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 39Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei66 – 92Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei122 – 147Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei175 – 198Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei226 – 252Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei281 – 299Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789431 – 318Mitochondrial glycine transporterAdd BLAST318

Interactioni

Protein-protein interaction databases

STRINGi426418.XP_001931061.1

Structurei

3D structure databases

ProteinModelPortaliB2VSU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 91Solcar 1UniRule annotationAdd BLAST84
Repeati116 – 200Solcar 2UniRule annotationAdd BLAST85
Repeati222 – 306Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0766 Eukaryota
ENOG410XRMK LUCA
InParanoidiB2VSU4
OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 1 hit
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

B2VSU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDGGKSSSS YFHFFAGLNS GILSAVLLQP ADLLKTRVQQ SRSSTLFGTI
60 70 80 90 100
QSIASGPNPV RQFWRGTLPS TLRTGFGSAI YFSSLNALRH RASLGAAGRA
110 120 130 140 150
DAAAKGAEHS SSLPKLSNTA NLATGAFART WAGFIMMPIT VLKVRYESNL
160 170 180 190 200
YAYNSLFTAS RDIFRTEGLK GFFAGFGATA VRDAPYAGLY VLFYEQSKRK
210 220 230 240 250
LSSLATKIEQ TSGASTKLST STSAGINFVS GVAAAGLGTT ITNPFDAIKT
260 270 280 290 300
RIQLMPERYG NMVQATKKMY MEEGLRCFFD GLGIRIARKA VSSALAWTLY
310
EELIRRAETL KEVVEDKI
Length:318
Mass (Da):34,364
Last modified:July 1, 2008 - v1
Checksum:iBFF739B77B742211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231615 Genomic DNA Translation: EDU40166.1
RefSeqiXP_001931061.1, XM_001931026.1

Genome annotation databases

EnsemblFungiiEDU40166; EDU40166; PTRG_00728
GeneIDi6340039

Similar proteinsi

Entry informationi

Entry nameiS2538_PYRTR
AccessioniPrimary (citable) accession number: B2VSU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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