B2VL12 (PQQC_ERWT9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrroloquinoline-quinone synthase
EC=1.3.3.11

Alternative name(s):
Coenzyme PQQ synthesis protein C
Pyrroloquinoline quinone biosynthesis protein C

Gene names

Name:	pqqC
Ordered Locus Names:	ETA_28880

Organism

Erwinia tasmaniensis (strain DSM 17950 / Et1/99) [Complete proteome] [HAMAP]

Taxonomic identifier

338565 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Erwinia

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity. HAMAP MF_00654
Catalytic activity	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O. HAMAP MF_00654
Pathway	Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. HAMAP MF_00654
Sequence similarities	Belongs to the pqqC family.

Ontologies

Keywords
Biological process	PQQ biosynthesis
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrroloquinoline quinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyrroloquinoline-quinone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	Pyrroloquinoline-quinone synthase HAMAP MF_00654		PRO_1000131176

Sequences

	Sequence		Length	Mass (Da)
	B2VL12 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 3ED600C541DBEDC7	FASTA	251	29,088
	10 20 30 40 50 60 MTEPALMTPQ QFEQALRARG AYYHIYHPYH IAMHNGEATR EQIQGWVANR FYYQTRIPLK 70 80 90 100 110 120 DAAIMANCPD AATRRKWVQR ILDHDGHDDS DGGIEAWLRL GEAVGLDREV LLSEQLVLPG 130 140 150 160 170 180 VRFAVDAYVS FARRAVWQEA ACSSLTELFA PEIHQSRLDS WPQHYPWIEE EGYGYFRGRL 190 200 210 220 230 240 GQARRDVEHG LQLALAYCNS VEKQQRMLEI LQFKLDILWS MLDAMTMAYT LNRAPYHTVT 250 DQPVWHQGKL L

References

[1]

"The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia." Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K. Environ. Microbiol. 10:2211-2222(2008) [PubMed: 18462403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17950 / Et1/99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU468135 Genomic DNA. Translation: CAO97934.1.
RefSeq	YP_001908803.1. NC_010694.1.
3D structure databases
ProteinModelPortal	B2VL12.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6299655.
GenomeReviews	Gene locus ETA_28880 in contig CU468135_GR.
PATRIC	20431693. VBIErwTas9546_2981.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG288944.
OMA	DSWPQHY.
ProtClustDB	PRK05157.
Family and domain databases
HAMAP	MF_00654. PQQ_syn_PqqC. [Tree]
InterPro	IPR016084. Haem_Oase-like_multi-hlx. IPR011845. PQQ_synth_PqqC. IPR004305. TENA/THI4/PQQ_synthPqqC_dom. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
Pfam	PF03070. TENA_THI-4. 1 hit. [Graphical view]
SUPFAM	SSF48613. Heme_oxygenase. 1 hit.
TIGRFAMs	TIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PQQC_ERWT9

Accession

Primary (citable) accession number: B2VL12

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program