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B2VKT2

- TRPB_ERWT9

UniProt

B2VKT2 - TRPB_ERWT9

Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotation

    Catalytic activityi

    L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. tryptophan synthase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciETAS465817:GI36-1659-MONOMER.
    UniPathwayiUPA00035; UER00044.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
    Gene namesi
    Name:trpBUniRule annotation
    Ordered Locus Names:ETA_16000
    OrganismiErwinia tasmaniensis (strain DSM 17950 / Et1/99)
    Taxonomic identifieri338565 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeErwinia
    ProteomesiUP000001726: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Tryptophan synthase beta chainPRO_1000095788Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei86 – 861N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiB2VKT2.

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains.UniRule annotation

    Protein-protein interaction databases

    STRINGi465817.ETA_16000.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0133.
    HOGENOMiHOG000161710.
    KOiK01696.
    OMAiEFMTLLQ.
    OrthoDBiEOG6GFGH7.

    Family and domain databases

    HAMAPiMF_00133. Trp_synth_beta.
    InterProiIPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    IPR006653. Trp_synth_b_CS.
    IPR006654. Trp_synth_beta.
    IPR023026. Trp_synth_beta/beta-like.
    [Graphical view]
    PANTHERiPTHR10314:SF3. PTHR10314:SF3. 1 hit.
    PfamiPF00291. PALP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00263. trpB. 1 hit.
    PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2VKT2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRLNPYFGE FGGMYVPQIL MPALLQLEDA FISAQSDPAF QAEFTDLLKN    50
    YAGRPTALTR CLNLTKGSKT RLYLKREDLL HGGAHKTNQV LGQALLAKRM 100
    GKKEIIAETG AGQHGVASAL ACALLGLKCR IYMGAKDIER QSPNLFRMRL 150
    MGAEVIPVHS GSATLKDACN EALRDWSGSY ETAHYMLGTA AGPHPFPTIV 200
    REFQRMIGEE TKAQILQQEG RLPDAVIACV GGGSNAIGMF ADFIDEPGVE 250
    LIGVEPGGHG IESGEHGAPL KHGRVGIYFG MKSPMMQTAD GQIEESYSIS 300
    AGLDFPSVGP QHAHLNSIGR ANYVSITDEE ALDAFKALCR SEGIIPALES 350
    SHALAHALKM MREAPEKEQL LVVNLSGRGD KDIFTVHDIL TAKGEI 396
    Length:396
    Mass (Da):42,742
    Last modified:July 1, 2008 - v1
    Checksum:iAA359CCBBD7798BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU468135 Genomic DNA. Translation: CAO96646.1.
    RefSeqiYP_001907539.1. NC_010694.1.

    Genome annotation databases

    EnsemblBacteriaiCAO96646; CAO96646; ETA_16000.
    GeneIDi6300215.
    KEGGieta:ETA_16000.
    PATRICi20429002. VBIErwTas9546_1673.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU468135 Genomic DNA. Translation: CAO96646.1 .
    RefSeqi YP_001907539.1. NC_010694.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 465817.ETA_16000.

    Proteomic databases

    PRIDEi B2VKT2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAO96646 ; CAO96646 ; ETA_16000 .
    GeneIDi 6300215.
    KEGGi eta:ETA_16000.
    PATRICi 20429002. VBIErwTas9546_1673.

    Phylogenomic databases

    eggNOGi COG0133.
    HOGENOMi HOG000161710.
    KOi K01696.
    OMAi EFMTLLQ.
    OrthoDBi EOG6GFGH7.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00044 .
    BioCyci ETAS465817:GI36-1659-MONOMER.

    Family and domain databases

    HAMAPi MF_00133. Trp_synth_beta.
    InterProi IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    IPR006653. Trp_synth_b_CS.
    IPR006654. Trp_synth_beta.
    IPR023026. Trp_synth_beta/beta-like.
    [Graphical view ]
    PANTHERi PTHR10314:SF3. PTHR10314:SF3. 1 hit.
    Pfami PF00291. PALP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001413. Trp_syn_beta. 1 hit.
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00263. trpB. 1 hit.
    PROSITEi PS00168. TRP_SYNTHASE_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia."
      Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K.
      Environ. Microbiol. 10:2211-2222(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17950 / Et1/99.

    Entry informationi

    Entry nameiTRPB_ERWT9
    AccessioniPrimary (citable) accession number: B2VKT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3