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B2VKT2 (TRPB_ERWT9) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan synthase beta chain

EC=4.2.1.20
Gene names
Name:trpB
Ordered Locus Names:ETA_16000
OrganismErwinia tasmaniensis (strain DSM 17950 / Et1/99) [Complete proteome] [HAMAP]
Taxonomic identifier338565 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeErwinia

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine By similarity. HAMAP-Rule MF_00133

Catalytic activity

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_00133

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00133

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP-Rule MF_00133

Subunit structure

Tetramer of two alpha and two beta chains By similarity.

Sequence similarities

Belongs to the TrpB family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   LigandPyridoxal phosphate
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functiontryptophan synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396Tryptophan synthase beta chain HAMAP-Rule MF_00133
PRO_1000095788

Amino acid modifications

Modified residue861N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B2VKT2 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: AA359CCBBD7798BA

FASTA39642,742
        10         20         30         40         50         60 
MTRLNPYFGE FGGMYVPQIL MPALLQLEDA FISAQSDPAF QAEFTDLLKN YAGRPTALTR 

        70         80         90        100        110        120 
CLNLTKGSKT RLYLKREDLL HGGAHKTNQV LGQALLAKRM GKKEIIAETG AGQHGVASAL 

       130        140        150        160        170        180 
ACALLGLKCR IYMGAKDIER QSPNLFRMRL MGAEVIPVHS GSATLKDACN EALRDWSGSY 

       190        200        210        220        230        240 
ETAHYMLGTA AGPHPFPTIV REFQRMIGEE TKAQILQQEG RLPDAVIACV GGGSNAIGMF 

       250        260        270        280        290        300 
ADFIDEPGVE LIGVEPGGHG IESGEHGAPL KHGRVGIYFG MKSPMMQTAD GQIEESYSIS 

       310        320        330        340        350        360 
AGLDFPSVGP QHAHLNSIGR ANYVSITDEE ALDAFKALCR SEGIIPALES SHALAHALKM 

       370        380        390 
MREAPEKEQL LVVNLSGRGD KDIFTVHDIL TAKGEI 

« Hide

References

[1]"The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia."
Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K.
Environ. Microbiol. 10:2211-2222(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17950 / Et1/99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU468135 Genomic DNA. Translation: CAO96646.1.
RefSeqYP_001907539.1. NC_010694.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING465817.ETA_16000.

Proteomic databases

PRIDEB2VKT2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAO96646; CAO96646; ETA_16000.
GeneID6300215.
KEGGeta:ETA_16000.
PATRIC20429002. VBIErwTas9546_1673.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0133.
HOGENOMHOG000161710.
KOK01696.
OMAIGRAEYV.
OrthoDBEOG6GFGH7.
ProtClustDBPRK04346.

Enzyme and pathway databases

BioCycETAS465817:GI36-1659-MONOMER.
UniPathwayUPA00035; UER00044.

Family and domain databases

HAMAPMF_00133. Trp_synth_beta.
InterProIPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
IPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
[Graphical view]
PANTHERPTHR10314:SF3. PTHR10314:SF3. 1 hit.
PfamPF00291. PALP. 1 hit.
[Graphical view]
PIRSFPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMSSF53686. SSF53686. 1 hit.
TIGRFAMsTIGR00263. trpB. 1 hit.
PROSITEPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPB_ERWT9
AccessionPrimary (citable) accession number: B2VKT2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: February 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways