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Protein

Chorismate pyruvate-lyase

Gene

ubiC

Organism
Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.UniRule annotation

Catalytic activityi

Chorismate = 4-hydroxybenzoate + pyruvate.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36Substrate; via amide nitrogenUniRule annotation1
Binding sitei78SubstrateUniRule annotation1
Binding sitei116Substrate; via amide nitrogenUniRule annotation1
Binding sitei157SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processUbiquinone biosynthesis
LigandPyruvate

Enzyme and pathway databases

UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
Chorismate pyruvate-lyaseUniRule annotation (EC:4.1.3.40UniRule annotation)
Short name:
CLUniRule annotation
Short name:
CPLUniRule annotation
Gene namesi
Name:ubiCUniRule annotation
Ordered Locus Names:ETA_31050
OrganismiErwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Taxonomic identifieri465817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeErwinia
Proteomesi
  • UP000001726 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001865281 – 174Chorismate pyruvate-lyaseAdd BLAST174

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi465817.ETA_31050

Structurei

3D structure databases

ProteinModelPortaliB2VKA5
SMRiB2VKA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105VEI Bacteria
COG3161 LUCA
HOGENOMiHOG000137785
KOiK03181
OMAiELWGRRS
OrthoDBiPOG091H047C

Family and domain databases

Gene3Di3.40.1410.10, 1 hit
HAMAPiMF_01632 UbiC, 1 hit
InterProiView protein in InterPro
IPR007440 Chorismate--pyruvate_lyase
IPR028978 Chorismate_lyase_/UTRA_dom_sf
PANTHERiPTHR38683 PTHR38683, 1 hit
PfamiView protein in Pfam
PF04345 Chor_lyase, 1 hit
SUPFAMiSSF64288 SSF64288, 1 hit

Sequencei

Sequence statusi: Complete.

B2VKA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENALPLLS AIEWLPEPSP LLTASLLDWL LEADSMTRRF EAHCQKVTVN
60 70 80 90 100
LLREAFISPE EIAAEAALLP PEKQYWLREI ELCADGIPWL VARTLVPEST
110 120 130 140 150
LVGPEQKLRQ LGSVPLGRYL FASSSLTRDF IDVGQSAGLW ARRSRLRLAG
160 170
KPLLLTELFL PASPLYGSLA KENT
Length:174
Mass (Da):19,364
Last modified:July 1, 2008 - v1
Checksum:i1505D734C3C8D749
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA Translation: CAO98151.1
RefSeqiWP_012442801.1, NC_010694.1

Genome annotation databases

EnsemblBacteriaiCAO98151; CAO98151; ETA_31050
KEGGieta:ETA_31050

Similar proteinsi

Entry informationi

Entry nameiUBIC_ERWT9
AccessioniPrimary (citable) accession number: B2VKA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health