Reviewed, UniProtKB/Swiss-Prot B2VK11 (ADD_ERWT9)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	ETA_17650

Organism

Erwinia tasmaniensis (strain DSM 17950 / Et1/99) [Complete proteome] [HAMAP]

Taxonomic identifier

338565 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Erwinia

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Adenosine deaminase HAMAP MF_00540		PRO_1000128847
Sites
	Active site	197	1	Potential
	Active site	245	1	Potential
	Active site	278	1	Potential
	Active site	279	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	B2VK11-1 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: E7A57711BC50B7F4	FASTA	332	35,708
	10 20 30 40 50 60 MIDSQLPLTD IHRHLDGNIR AQTILDLGRE FNLTLPATTL AALRPHVQVI EAEPDLVSFL 70 80 90 100 110 120 NKLDWGVKVL GSLDACRRVA LENVEDAARA GIHYAELRFS PGYMAMTHGL PVAGVVEAVI 130 140 150 160 170 180 DGIRAGCAAH NIDVRLIGIM SRTFGEDACL RELDGLLAHR DGITALDLAG DELGFPGRRF 190 200 210 220 230 240 LSHFNRARDA GLRITVHAGE AAGAESIWQA IRELGAERIG HGVKAVEDPA LMDFLAQEGI 250 260 270 280 290 300 GIESCLTSNI QTSTVATLAD HPLKTFLNHG ILATINTDDP AVQGIEIEHE YHVAAPAAGL 310 320 330 SVQQMRVAQE NGLKIAFLSE EEKAAVRARL AA

References

[1]

"The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia." Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K. Environ. Microbiol. 10:2211-2222(2008) [PubMed: 18462403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU468135 Genomic DNA. Translation: CAO96811.1.
RefSeq	YP_001907700.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6300718.
GenomeReviews	Gene locus ETA_17650 in contig CU468135_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	FLKKLDW.
Family and domain databases
HAMAP	MF_00540. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_ERWT9

Accession

Primary (citable) accession number: B2VK11

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 1, 2008
Last modified:	November 3, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)