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B2VJX8 (ASTD_ERWT9) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71
Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD
Gene names
Name:astD
Ordered Locus Names:ETA_18570
OrganismErwinia tasmaniensis (strain DSM 17950 / Et1/99) [Complete proteome] [HAMAP]
Taxonomic identifier338565 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Erwinia

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174
PRO_1000138049

Regions

Nucleotide binding216 – 2216NAD By similarity

Sites

Active site2391 By similarity
Active site2731 By similarity

Sequences

Sequence LengthMass (Da)Tools
B2VJX8 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 882E7189BC838B34

FASTA48952,719
        10         20         30         40         50         60 
MTHCINGQWL AGEGETVIKT DPVSGEVLWQ GRGASAAQVA AACEAARGAF PAWARQPFAE 

        70         80         90        100        110        120 
RQAIVEKFAA LLDTNRVELS EAIARETGKP RWETQTEVQA MINKVAISLR AWHVRCPEQV 

       130        140        150        160        170        180 
EGESSVRHRP HGVMAVFGPY NFPGHLPNGH IVPALLAGNC VLFKPSELTP LTAEIAMRLW 

       190        200        210        220        230        240 
NHAGLPQGVL HLLQGGRETG QALVQQPQVD GILFTGSAAT GYQLHRQLAG QPEKMLALEM 

       250        260        270        280        290        300 
GGNNALIVED PDDIDAAVHI AIQSAFISAG QRCTCARRLL VRRGAAGDAF LARLAAVAAT 

       310        320        330        340        350        360 
IRVGRWNDEP QPFMGSVISP QAAEKIYAEW QARIDAGGNV LLPMCWPERS SALLTPGIID 

       370        380        390        400        410        420 
VTEVRDLPDE EIFGPLLQVM RYDDFTHAIQ LANDTRYGLA CGLISPQREK FDRLLVEARA 

       430        440        450        460        470        480 
GIVNWNKPLT GAASTAPFGG VGASGNHRPS AWYAADYCAW PMASLASADL SLPDTLSPGL 


DFSVNKEAE

« Hide

References

[1]"The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia."
Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K.
Environ. Microbiol. 10:2211-2222(2008) [PubMed: 18462403] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17950 / Et1/99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU468135 Genomic DNA. Translation: CAO96903.1.
RefSeqYP_001907790.1. NC_010694.1.

3D structure databases

ProteinModelPortalB2VJX8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6297827.
GenomeReviewsGene locus ETA_18570 in contig CU468135_GR.
PATRIC20429543. VBIErwTas9546_1940.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG752218.
OMATHYIAGN.
ProtClustDBCLSK2543534.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699:SF24. PTHR11699:SF24. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03240. Arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASTD_ERWT9
AccessionPrimary (citable) accession number: B2VJX8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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