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Protein

5'-deoxynucleotidase ETA_12010

Gene

ETA_12010

Organism
Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.UniRule annotation

Catalytic activityi

A 2'-deoxyribonucleoside 5'-monophosphate + H2O = a 2'-deoxyribonucleoside + phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei18Appears to be important in orienting the phosphate for catalysisUniRule annotation1
Metal bindingi33Divalent metal cation; via tele nitrogenUniRule annotation1
Binding sitei33SubstrateUniRule annotation1
Metal bindingi68Divalent metal cation; via tele nitrogenUniRule annotation1
Metal bindingi69Divalent metal cationUniRule annotation1
Binding sitei69SubstrateUniRule annotation1
Metal bindingi137Divalent metal cationUniRule annotation1
Binding sitei137SubstrateUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
5'-deoxynucleotidase ETA_12010UniRule annotation (EC:3.1.3.89UniRule annotation)
Alternative name(s):
5'-deoxyribonucleotidaseUniRule annotation
Nucleoside 5'-monophosphate phosphohydrolaseUniRule annotation
Gene namesi
Ordered Locus Names:ETA_12010
OrganismiErwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Taxonomic identifieri465817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeErwinia
Proteomesi
  • UP000001726 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001369691 – 1985'-deoxynucleotidase ETA_12010Add BLAST198

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi465817.ETA_12010.

Structurei

3D structure databases

ProteinModelPortaliB2VIV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni18 – 19Substrate bindingUniRule annotation2
Regioni77 – 80Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the 5DNU family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DK2. Bacteria.
COG1896. LUCA.
HOGENOMiHOG000276964.
KOiK08722.
OMAiMPTPIKY.
OrthoDBiPOG091H00DC.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
HAMAPiMF_01100. 5DNU. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR022971. YfbR.
[Graphical view]
PfamiPF13023. HD_3. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2VIV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHSHFFAHL SRLKLINRWP LMRNVRTENV SEHSLQVAMV AHALALIKNA
60 70 80 90 100
RFAGNLNPER IALMAVYHDA SEVLTGDLPT PVKYYNAQIA HEYKKIEKIA
110 120 130 140 150
QHKLIEMLPE ELRSAYAPLI DEHQHSEAET AIVKQADALC AYLKCLEELS
160 170 180 190
AGNNEFLTAK ARLEKTLAQR RSQEMDYFME VFVPSFSLSL DEISQESL
Length:198
Mass (Da):22,617
Last modified:July 1, 2008 - v1
Checksum:iC7B92F8641362310
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA. Translation: CAO96247.1.
RefSeqiWP_012440944.1. NC_010694.1.

Genome annotation databases

EnsemblBacteriaiCAO96247; CAO96247; ETA_12010.
KEGGieta:ETA_12010.
PATRICi20428130. VBIErwTas9546_1245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA. Translation: CAO96247.1.
RefSeqiWP_012440944.1. NC_010694.1.

3D structure databases

ProteinModelPortaliB2VIV0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi465817.ETA_12010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAO96247; CAO96247; ETA_12010.
KEGGieta:ETA_12010.
PATRICi20428130. VBIErwTas9546_1245.

Phylogenomic databases

eggNOGiENOG4105DK2. Bacteria.
COG1896. LUCA.
HOGENOMiHOG000276964.
KOiK08722.
OMAiMPTPIKY.
OrthoDBiPOG091H00DC.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
HAMAPiMF_01100. 5DNU. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR022971. YfbR.
[Graphical view]
PfamiPF13023. HD_3. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei5DNU_ERWT9
AccessioniPrimary (citable) accession number: B2VIV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: November 30, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.