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Protein

Cytidine deaminase

Gene

cdd

Organism
Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.UniRule annotation

Catalytic activityi

Cytidine + H2O = uridine + NH3.UniRule annotation
2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi102Zinc; catalyticUniRule annotation1
Active sitei104Proton donorUniRule annotation1
Metal bindingi129Zinc; catalyticUniRule annotation1
Metal bindingi132Zinc; catalyticUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine deaminaseUniRule annotation (EC:3.5.4.5UniRule annotation)
Alternative name(s):
Cytidine aminohydrolaseUniRule annotation
Short name:
CDAUniRule annotation
Gene namesi
Name:cddUniRule annotation
Ordered Locus Names:ETA_12960
OrganismiErwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Taxonomic identifieri465817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeErwinia
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001471031 – 296Cytidine deaminaseAdd BLAST296

Proteomic databases

PRIDEiB2VIF3

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi465817.ETA_12960

Structurei

3D structure databases

ProteinModelPortaliB2VIF3
SMRiB2VIF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 168CMP/dCMP-type deaminase 1PROSITE-ProRule annotationAdd BLAST121
Domaini186 – 296CMP/dCMP-type deaminase 2PROSITE-ProRule annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni89 – 91Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T42 Bacteria
COG0295 LUCA
HOGENOMiHOG000218617
KOiK01489
OMAiGHIDAQQ
OrthoDBiPOG091H026Y

Family and domain databases

HAMAPiMF_01558 Cyt_deam, 1 hit
InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR002125 CMP_dCMP_dom
IPR013171 Cyd/dCyd_deaminase_Zn-bd
IPR006263 Cyt_deam_dimer
IPR016193 Cytidine_deaminase-like
IPR020797 Cytidine_deaminase_bacteria
PfamiView protein in Pfam
PF00383 dCMP_cyt_deam_1, 1 hit
PF08211 dCMP_cyt_deam_2, 1 hit
SUPFAMiSSF53927 SSF53927, 2 hits
TIGRFAMsiTIGR01355 cyt_deam_dimer, 1 hit
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 2 hits

Sequencei

Sequence statusi: Complete.

B2VIF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPRFQTAFA TLSPLLQQAI RPILSSADFA GFISAQQADG VKQQCGLDDS
60 70 80 90 100
ELAFTLLPLA AACAVAPLSD FNVGAVARGK SGTLYFGANM EFVGATMQQT
110 120 130 140 150
VHAEQSAVTH AWLRGESGLA GITVNYTPCG HCRQFMNELN SGTDLTIELP
160 170 180 190 200
GRAAATLGHY LPDSFGPRDL AITTLLMDEV DHGIAPRGDK LEQAALAAAN
210 220 230 240 250
QSHAPYSGAC SGVALQTRSG AIYAGRYAEN AAFNPSLPPL QGALNLLNLG
260 270 280 290
GEELSDIRRA VLAEASGAKL SQRSASAATL AALGCHDLIT IPLVKM
Length:296
Mass (Da):30,862
Last modified:July 1, 2008 - v1
Checksum:i27BAED2125A32084
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA Translation: CAO96342.1
RefSeqiWP_012441036.1, NC_010694.1

Genome annotation databases

EnsemblBacteriaiCAO96342; CAO96342; ETA_12960
KEGGieta:ETA_12960

Entry informationi

Entry nameiCDD_ERWT9
AccessioniPrimary (citable) accession number: B2VIF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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