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B2VI13 (HEM6_ERWT9) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic
Short name=Coprogen oxidase
Short name=Coproporphyrinogenase
EC=1.3.3.3
Gene names
Name:hemF
Ordered Locus Names:ETA_10850
OrganismErwinia tasmaniensis (strain DSM 17950 / Et1/99) [Complete proteome] [HAMAP]
Taxonomic identifier338565 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Erwinia

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333

Subunit structure

Homodimer By similarity. HAMAP MF_00333

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncoproporphyrinogen oxidase activity

Inferred from electronic annotation. Source: EC

protein homodimerization activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
PRO_1000119803

Regions

Region50 – 5910Important for dimerization By similarity
Region110 – 1123Substrate binding By similarity
Region242 – 27736Important for dimerization By similarity
Region260 – 2656Substrate binding By similarity

Sites

Active site1081Proton donor By similarity
Binding site941Substrate By similarity
Site1771Important for dimerization By similarity

Sequences

Sequence LengthMass (Da)Tools
B2VI13 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 46FA2EBF9739AF1D

FASTA30234,851
        10         20         30         40         50         60 
MNTPDIAQVK RFLLNLQDEI CQKLEQADGA ARFAEDSWQR PGGGGGRSRV LRQGRVFEQA 

        70         80         90        100        110        120 
GVNFSHVHGD EMPASATAHR PELAGRSFEA LGVSLVIHPE NPYIPTSHAN VRFFIAEKPG 

       130        140        150        160        170        180 
ADPVWWFGGG FDLTPFYGFT EDAVHWHQTA FDLCLPFGAE VYPRYKKWCD DYFHLKHRNE 

       190        200        210        220        230        240 
QRGIGGLFFD DLNAHGFDQS FRFMQAVGRG FCDAYLPIVE RRKALTWGER ERDFQLYRRG 

       250        260        270        280        290        300 
RYVEFNLVWD RGTLFGLQTG GRTESILMSM PPLVRWEYDY QPREDSPEAA LYRDFIVVKE 


WL

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References

[1]"The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia."
Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K.
Environ. Microbiol. 10:2211-2222(2008) [PubMed: 18462403] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17950 / Et1/99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU468135 Genomic DNA. Translation: CAO96131.1.
RefSeqYP_001907028.1. NC_010694.1.

3D structure databases

ProteinModelPortalB2VI13.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6300065.
GenomeReviewsGene locus ETA_10850 in contig CU468135_GR.
PATRIC20427880. VBIErwTas9546_1127.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG631180.
OMAVKAYLLD.
ProtClustDBPRK05330.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM6_ERWT9
AccessionPrimary (citable) accession number: B2VI13
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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