B2VH50 (DEOC_ERWT9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	ETA_06660

Organism

Erwinia tasmaniensis (strain DSM 17950 / Et1/99) [Complete proteome] [HAMAP]

Taxonomic identifier

338565 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Erwinia

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00592
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00592
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00592
Subcellular location	Cytoplasm By similarity HAMAP MF_00592.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Deoxyribose-phosphate aldolase HAMAP MF_00592		PRO_1000129807
Sites
	Active site	167	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	201	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2VH50 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 4BDE274F9F5DA068	FASTA	259	27,594
	10 20 30 40 50 60 MSEVKDRALR ALQLMDLTTL NDDDTDAKVI ALCHQAKSPA GNTAAICIYP RFIPLARKTL 70 80 90 100 110 120 REQGTPEIRI ATVTNFPHGN DDSEIALAET RAAIAYGADE VDVVFPYRAL MAGNEAIGFE 130 140 150 160 170 180 LVKACKQACR EANVLLKVII ESGELKEASL IRKASEIAID AGADFIKTST GKVAVNATPE 190 200 210 220 230 240 VAEIMLRTIA AKGVQKQVGF KPAGGVRSAD DAALYLKLAD NILGPDWADA RHFRFGASSL 250 LASLLNAAGF NGATSDSNY

References

[1]

"The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia." Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K. Environ. Microbiol. 10:2211-2222(2008) [PubMed: 18462403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17950 / Et1/99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU468135 Genomic DNA. Translation: CAO95712.1.
RefSeq	YP_001906610.1. NC_010694.1.
3D structure databases
ProteinModelPortal	B2VH50.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6300604.
GenomeReviews	Gene locus ETA_06660 in contig CU468135_GR.
PATRIC	20427046. VBIErwTas9546_0714.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG636421.
OMA	ELVQQCK.
ProtClustDB	PRK05283.
Family and domain databases
HAMAP	MF_00592. DeoC_type2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR023649. DeoC_bac. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_ERWT9

Accession

Primary (citable) accession number: B2VH50

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program