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Protein

3-dehydroquinate dehydratase

Gene

aroQ

Organism
Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes a trans-dehydration via an enolate intermediate.UniRule annotation

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.UniRule annotation

Pathwayi: chorismate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (aroF), Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG), Phospho-2-dehydro-3-deoxyheptonate aldolase (aroH)
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase 2 (aroL), Shikimate kinase 1 (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei21Transition state stabilizerUniRule annotation1
Active sitei26Proton acceptorUniRule annotation1
Binding sitei77SubstrateUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei90SubstrateUniRule annotation1
Active sitei103Proton donorUniRule annotation1
Binding sitei114SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00053; UER00086

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydrataseUniRule annotation (EC:4.2.1.10UniRule annotation)
Short name:
3-dehydroquinaseUniRule annotation
Alternative name(s):
Type II DHQaseUniRule annotation
Gene namesi
Name:aroQUniRule annotation
Ordered Locus Names:ETA_02790
OrganismiErwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Taxonomic identifieri465817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeErwinia
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000975991 – 1503-dehydroquinate dehydrataseAdd BLAST150

Interactioni

Subunit structurei

Homododecamer.UniRule annotation

Protein-protein interaction databases

STRINGi465817.ETA_02790

Structurei

3D structure databases

SMRiB2VGX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 105Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the type-II 3-dehydroquinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z38 Bacteria
COG0757 LUCA
HOGENOMiHOG000217278
KOiK03786
OMAiAYTHYSY
OrthoDBiPOG091H03XJ

Family and domain databases

CDDicd00466 DHQase_II, 1 hit
Gene3Di3.40.50.9100, 1 hit
HAMAPiMF_00169 AroQ, 1 hit
InterProiView protein in InterPro
IPR001874 DHquinase_II
IPR018509 DHquinase_II_CS
IPR036441 DHquinase_II_sf
PANTHERiPTHR21272 PTHR21272, 1 hit
PfamiView protein in Pfam
PF01220 DHquinase_II, 1 hit
PIRSFiPIRSF001399 DHquinase_II, 1 hit
SUPFAMiSSF52304 SSF52304, 1 hit
TIGRFAMsiTIGR01088 aroQ, 1 hit
PROSITEiView protein in PROSITE
PS01029 DEHYDROQUINASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

B2VGX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKLHVLLL NGPNLNLLGT REPEKYGHTS LDEIVSELTL QASALGVTLS
60 70 80 90 100
HLQSNAEHAL IDRIHQAKGN VDYIVINPAA FTHTSVALRD ALLAVSIPFI
110 120 130 140 150
EVHLSNVHAR EPFRHHSYLS DISTGVICGL GVDGYSWALQ TAVKRLSLSH
Length:150
Mass (Da):16,361
Last modified:July 1, 2008 - v1
Checksum:i490CFBFF77C2DED8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA Translation: CAO95325.1
RefSeqiWP_012440044.1, NC_010694.1

Genome annotation databases

EnsemblBacteriaiCAO95325; CAO95325; ETA_02790
KEGGieta:ETA_02790

Entry informationi

Entry nameiAROQ_ERWT9
AccessioniPrimary (citable) accession number: B2VGX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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