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B2VGJ3

- UPPP_ERWT9

UniProt

B2VGJ3 - UPPP_ERWT9

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, ETA_04210
Organism
Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciETAS465817:GI36-456-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:ETA_04210
OrganismiErwinia tasmaniensis (strain DSM 17950 / Et1/99)
Taxonomic identifieri338565 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeErwinia
ProteomesiUP000001726: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed predictionAdd
BLAST
Transmembranei45 – 6521Helical; Reviewed predictionAdd
BLAST
Transmembranei89 – 10921Helical; Reviewed predictionAdd
BLAST
Transmembranei115 – 13521Helical; Reviewed predictionAdd
BLAST
Transmembranei152 – 17120Helical; Reviewed predictionAdd
BLAST
Transmembranei189 – 20921Helical; Reviewed predictionAdd
BLAST
Transmembranei221 – 24121Helical; Reviewed predictionAdd
BLAST
Transmembranei253 – 27321Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Undecaprenyl-diphosphataseUniRule annotationPRO_1000197364Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi465817.ETA_04210.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

B2VGJ3-1 [UniParc]FASTAAdd to Basket

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MTDIHQLWIA AILGLVEGLT EFLPVSSTGH MILVGHLLGF EGNKAETFEV    50
VIQLGSILAV VVMFWRRLFG LIGIHFGEVP HEGSGQGRLT LIHILLGMVP 100
AVVIGLLLHD QIKTLFNPVN VMYALVVGGV LLIAAELLKP KRPKSPGVDD 150
ITYRQAFMIG CFQCLALWPG FSRSGATISG GMLVGVSRYA ASEFSFLLAV 200
PMMIGATGLD LYKSMGFLSM ADFPMFAVGF VTAFIVALIA IKSFLHIIKR 250
ISFIPFAIYR FIVAAAVYAL FVL 273
Length:273
Mass (Da):29,632
Last modified:July 1, 2008 - v1
Checksum:iDE96D57060A3DD00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU468135 Genomic DNA. Translation: CAO95467.1.
RefSeqiYP_001906372.1. NC_010694.1.

Genome annotation databases

EnsemblBacteriaiCAO95467; CAO95467; ETA_04210.
GeneIDi6301038.
KEGGieta:ETA_04210.
PATRICi20426548. VBIErwTas9546_0469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU468135 Genomic DNA. Translation: CAO95467.1 .
RefSeqi YP_001906372.1. NC_010694.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 465817.ETA_04210.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAO95467 ; CAO95467 ; ETA_04210 .
GeneIDi 6301038.
KEGGi eta:ETA_04210.
PATRICi 20426548. VBIErwTas9546_0469.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci ETAS465817:GI36-456-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia."
    Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K.
    Environ. Microbiol. 10:2211-2222(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17950 / Et1/99.

Entry informationi

Entry nameiUPPP_ERWT9
AccessioniPrimary (citable) accession number: B2VGJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi