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B2VG81

- PUR9_ERWT9

UniProt

B2VG81 - PUR9_ERWT9

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciETAS465817:GI36-193-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:ETA_01800
    OrganismiErwinia tasmaniensis (strain DSM 17950 / Et1/99)
    Taxonomic identifieri338565 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeErwinia
    ProteomesiUP000001726: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 529529Bifunctional purine biosynthesis protein PurHPRO_1000096064Add
    BLAST

    Proteomic databases

    PRIDEiB2VG81.

    Interactioni

    Protein-protein interaction databases

    STRINGi465817.ETA_01800.

    Structurei

    3D structure databases

    ProteinModelPortaliB2VG81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230372.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2VG81-1 [UniParc]FASTAAdd to Basket

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    MQQHRPVRRA LLSVSDKAGI LEFAQALSQR GVELLSTGGT ARLLADAGLP    50
    VTEVSDYTGF PEMMDGRVKT LHPKVHGGIL GRRGQDDAIM TEHGISPIDM 100
    VVVNLYPFAQ TVSRADCSLE DAVENIDIGG PTMVRSAAKN HKDVAIVVKS 150
    SDYQAIIAEL DANECSLTLA TRFDLAIKAF EHTAAYDSMI ANYFGSMVPA 200
    YHGETTEPAG RFPRTLNLNF IKKQDMRYGE NSHQQAAFYI EEHVGEASVA 250
    TAQQVQGKAL SYNNIADTDA ALECVKEFDQ PACVIVKHAN PCGVATGSAI 300
    IEAYERAYQT DPTSAFGGII AFNRELDEAT ARAIISRQFV EVIIAPSASD 350
    AALKITAAKQ NVRVLTCGQW QQRQTGLDFK RVNGGLLVQD RDLGMVSDSQ 400
    LRVVSKRQPS EQELRDALFC WKVAKFVKSN AIVYARDNMT IGIGAGQMSR 450
    VYSAKIAAIK AADEGLEVTG SSMASDAFFP FRDGIDAAAA VGITCVIQPG 500
    GSIRDDEVIA AADEHGIAMI FTGMRHFRH 529
    Length:529
    Mass (Da):57,225
    Last modified:July 1, 2008 - v1
    Checksum:iD889C15E4486CBC2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU468135 Genomic DNA. Translation: CAO95226.1.
    RefSeqiYP_001906134.1. NC_010694.1.

    Genome annotation databases

    EnsemblBacteriaiCAO95226; CAO95226; ETA_01800.
    GeneIDi6299713.
    KEGGieta:ETA_01800.
    PATRICi20426020. VBIErwTas9546_0227.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU468135 Genomic DNA. Translation: CAO95226.1 .
    RefSeqi YP_001906134.1. NC_010694.1.

    3D structure databases

    ProteinModelPortali B2VG81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 465817.ETA_01800.

    Proteomic databases

    PRIDEi B2VG81.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAO95226 ; CAO95226 ; ETA_01800 .
    GeneIDi 6299713.
    KEGGi eta:ETA_01800.
    PATRICi 20426020. VBIErwTas9546_0227.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230372.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci ETAS465817:GI36-193-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia."
      Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K.
      Environ. Microbiol. 10:2211-2222(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17950 / Et1/99.

    Entry informationi

    Entry nameiPUR9_ERWT9
    AccessioniPrimary (citable) accession number: B2VG81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3