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B2VG72 (GPPA_ERWT9) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:ETA_01930
OrganismErwinia tasmaniensis (strain DSM 17950 / Et1/99) [Complete proteome] [HAMAP]
Taxonomic identifier338565 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeErwinia

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_1000146872

Sequences

Sequence LengthMass (Da)Tools
B2VG72 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 164A4574EE6E56D0

FASTA49454,728
        10         20         30         40         50         60 
MRSASSLYAA IDLGSNSFHM LVVREVAGSI QTIARIKRKV RLAAGLDADN NLSAEAMDRG 

        70         80         90        100        110        120 
WQCLRLFSEQ LQDIPPEQIR VVATATLRIA ANAGSFLAQA QKLLGCPVNV ISGEEEARLI 

       130        140        150        160        170        180 
YQGVSHTTGG SDKRLVVDIG GGSTELVTGR GSQPTTLYSL SMGCVTWLER YFSDRQLGKV 

       190        200        210        220        230        240 
NFEQAEQAAR AMIRPIADSL KAQGWQVCVG ASGTVQALQE IMMAQGMDER ITLNKLQQLK 

       250        260        270        280        290        300 
QRAIECGKLE ELEIEGLTLE RALVFPSGLS ILIAIFSELN ISSMTLAGGA LREGLLYGML 

       310        320        330        340        350        360 
PLPVDRDIRS RTLHDVQRRF SVDPEQAERV RQLADSFARQ VSLQWKLDDR SRELLGSACL 

       370        380        390        400        410        420 
LHEIGLSVDF RQAPQHAAYL VRYLDLPGFT PAQKKLLATL LQNQVGNIDL PLLSQQNALL 

       430        440        450        460        470        480 
PRIAERLSRL LRLAIIFASR RRDDRLPAVR LQADDDNLTV TLPSGWLEAH PLRAELLEQE 

       490 
ARWQGYVHWP LIIA 

« Hide

References

[1]"The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia."
Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K.
Environ. Microbiol. 10:2211-2222(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17950 / Et1/99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU468135 Genomic DNA. Translation: CAO95239.1.
RefSeqYP_001906147.1. NC_010694.1.

3D structure databases

ProteinModelPortalB2VG72.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING465817.ETA_01930.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAO95239; CAO95239; ETA_01930.
GeneID6299772.
KEGGeta:ETA_01930.
PATRIC20426060. VBIErwTas9546_0240.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMAGLHIEYK.
OrthoDBEOG6M6JN6.

Enzyme and pathway databases

BioCycETAS465817:GI36-213-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsTIGR03706. exo_poly_only. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGPPA_ERWT9
AccessionPrimary (citable) accession number: B2VG72
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways