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B2VG72

- GPPA_ERWT9

UniProt

B2VG72 - GPPA_ERWT9

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. exopolyphosphatase activity Source: InterPro
  2. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
  3. polyphosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciETAS465817:GI36-213-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:ETA_01930
OrganismiErwinia tasmaniensis (strain DSM 17950 / Et1/99)
Taxonomic identifieri338565 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeErwinia
ProteomesiUP000001726: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000146872Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi465817.ETA_01930.

Structurei

3D structure databases

ProteinModelPortaliB2VG72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

Sequencei

Sequence statusi: Complete.

B2VG72-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSASSLYAA IDLGSNSFHM LVVREVAGSI QTIARIKRKV RLAAGLDADN
60 70 80 90 100
NLSAEAMDRG WQCLRLFSEQ LQDIPPEQIR VVATATLRIA ANAGSFLAQA
110 120 130 140 150
QKLLGCPVNV ISGEEEARLI YQGVSHTTGG SDKRLVVDIG GGSTELVTGR
160 170 180 190 200
GSQPTTLYSL SMGCVTWLER YFSDRQLGKV NFEQAEQAAR AMIRPIADSL
210 220 230 240 250
KAQGWQVCVG ASGTVQALQE IMMAQGMDER ITLNKLQQLK QRAIECGKLE
260 270 280 290 300
ELEIEGLTLE RALVFPSGLS ILIAIFSELN ISSMTLAGGA LREGLLYGML
310 320 330 340 350
PLPVDRDIRS RTLHDVQRRF SVDPEQAERV RQLADSFARQ VSLQWKLDDR
360 370 380 390 400
SRELLGSACL LHEIGLSVDF RQAPQHAAYL VRYLDLPGFT PAQKKLLATL
410 420 430 440 450
LQNQVGNIDL PLLSQQNALL PRIAERLSRL LRLAIIFASR RRDDRLPAVR
460 470 480 490
LQADDDNLTV TLPSGWLEAH PLRAELLEQE ARWQGYVHWP LIIA
Length:494
Mass (Da):54,728
Last modified:July 1, 2008 - v1
Checksum:i164A4574EE6E56D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA. Translation: CAO95239.1.
RefSeqiYP_001906147.1. NC_010694.1.

Genome annotation databases

EnsemblBacteriaiCAO95239; CAO95239; ETA_01930.
GeneIDi6299772.
KEGGieta:ETA_01930.
PATRICi20426060. VBIErwTas9546_0240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA. Translation: CAO95239.1 .
RefSeqi YP_001906147.1. NC_010694.1.

3D structure databases

ProteinModelPortali B2VG72.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 465817.ETA_01930.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAO95239 ; CAO95239 ; ETA_01930 .
GeneIDi 6299772.
KEGGi eta:ETA_01930.
PATRICi 20426060. VBIErwTas9546_0240.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci ETAS465817:GI36-213-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03706. exo_poly_only. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia."
    Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K.
    Environ. Microbiol. 10:2211-2222(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17950 / Et1/99.

Entry informationi

Entry nameiGPPA_ERWT9
AccessioniPrimary (citable) accession number: B2VG72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: October 1, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3