Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi: ppGpp biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes ppGpp from GTP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA)
This subpathway is part of the pathway ppGpp biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ppGpp from GTP, the pathway ppGpp biosynthesis and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00908; UER00885

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:ETA_01930
OrganismiErwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Taxonomic identifieri465817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeErwinia
Proteomesi
  • UP000001726 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001468721 – 494Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseAdd BLAST494

Interactioni

Protein-protein interaction databases

STRINGi465817.ETA_01930

Structurei

3D structure databases

ProteinModelPortaliB2VG72
SMRiB2VG72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9X Bacteria
COG0248 LUCA
HOGENOMiHOG000258672
KOiK01524
OMAiWQICVGA
OrthoDBiPOG091H00D6

Family and domain databases

HAMAPiMF_01550 GppA, 1 hit
InterProiView protein in InterPro
IPR022371 Exopolyphosphatase
IPR023709 Guo-5TP_3DP_PyrP
IPR003695 Ppx_GppA
IPR030673 PyroPPase_GppA_Ppx
PfamiView protein in Pfam
PF02541 Ppx-GppA, 1 hit
PIRSFiPIRSF001267 Pyrophosphatase_GppA_Ppx, 1 hit
TIGRFAMsiTIGR03706 exo_poly_only, 1 hit

Sequencei

Sequence statusi: Complete.

B2VG72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSASSLYAA IDLGSNSFHM LVVREVAGSI QTIARIKRKV RLAAGLDADN
60 70 80 90 100
NLSAEAMDRG WQCLRLFSEQ LQDIPPEQIR VVATATLRIA ANAGSFLAQA
110 120 130 140 150
QKLLGCPVNV ISGEEEARLI YQGVSHTTGG SDKRLVVDIG GGSTELVTGR
160 170 180 190 200
GSQPTTLYSL SMGCVTWLER YFSDRQLGKV NFEQAEQAAR AMIRPIADSL
210 220 230 240 250
KAQGWQVCVG ASGTVQALQE IMMAQGMDER ITLNKLQQLK QRAIECGKLE
260 270 280 290 300
ELEIEGLTLE RALVFPSGLS ILIAIFSELN ISSMTLAGGA LREGLLYGML
310 320 330 340 350
PLPVDRDIRS RTLHDVQRRF SVDPEQAERV RQLADSFARQ VSLQWKLDDR
360 370 380 390 400
SRELLGSACL LHEIGLSVDF RQAPQHAAYL VRYLDLPGFT PAQKKLLATL
410 420 430 440 450
LQNQVGNIDL PLLSQQNALL PRIAERLSRL LRLAIIFASR RRDDRLPAVR
460 470 480 490
LQADDDNLTV TLPSGWLEAH PLRAELLEQE ARWQGYVHWP LIIA
Length:494
Mass (Da):54,728
Last modified:July 1, 2008 - v1
Checksum:i164A4574EE6E56D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA Translation: CAO95239.1
RefSeqiWP_012439959.1, NC_010694.1

Genome annotation databases

EnsemblBacteriaiCAO95239; CAO95239; ETA_01930
KEGGieta:ETA_01930

Similar proteinsi

Entry informationi

Entry nameiGPPA_ERWT9
AccessioniPrimary (citable) accession number: B2VG72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health