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Protein

Catalase-peroxidase

Gene

katG

Organism
Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei105 – 1051Transition state stabilizerUniRule annotation
Active sitei109 – 1091Proton acceptorUniRule annotation
Metal bindingi270 – 2701Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciETAS465817:GI36-1463-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:ETA_14080
OrganismiErwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Taxonomic identifieri465817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeErwinia
Proteomesi
  • UP000001726 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Catalase-peroxidasePRO_0000354774Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki108 ↔ 229Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-255)UniRule annotation
Cross-linki229 ↔ 255Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-108)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi465817.ETA_14080.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2VFG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAHNTNESA VGKCPFHEQK EEKSVLARGA GGGTSNRDWW PEQLRVDLLN
60 70 80 90 100
QHSRRSNPLN EHFNYREEFA KLDYPQLKAD LKSLLNDSQE WWPADWGSYI
110 120 130 140 150
GLFIRMAWHS AGTYRTVDGR GGSGRGQQRF APLNAWPDNV SLDKARRLLW
160 170 180 190 200
PVKQKYGQKI SWADLYILAG NVALENSGFR TFGFAAGRED VWEPDLDINW
210 220 230 240 250
GEEKEWLTHR HPESLANAPL GATEMGLIYV NPEGPEASGN PASAAPAIRA
260 270 280 290 300
TFGNMGMNDE EIVALIAGGH TLGKTHGAGE ASHVGVDPEA APLESQGLGW
310 320 330 340 350
TSSYGSGSGA DAITSGLEVI WTQTPTQWSN YFFENLFKYE WVQTHSPAGA
360 370 380 390 400
IQFEAQDAQA SIPDPFDADK KRKPTMLVTD LTLRFDPEFE KISRRFLQDP
410 420 430 440 450
QSFNEAFARA WFKLTHRDMG PKARYLGPEV PKEDLIWQDP LPAPVHQPSP
460 470 480 490 500
GEINDVKAQI AQSGLSVSEL VSVAWASAST FRGGDKRGGA NGARLALAPQ
510 520 530 540 550
KEWPVNAIAS RALPQLQAIQ QASGKISLAD TLVLAGVVGI EQAAAAAGVS
560 570 580 590 600
IDVPFTPGRV DARQEQTDID SFDLLQPLAD GFRNYRRVTG GPSTETLLID
610 620 630 640 650
KAQQLTLSTP ELTVLVGGLR VLGTNFDGGK HGVLTEHAGV LSNDFFVNLL
660 670 680 690 700
DMRTAWRAAD DSAELFEGYD RKSGEVRYSA TRADLVFGSN AILRASAEVY
710 720
ASADAQQKFI TDFVAAWGKV MDLDRFDIR
Length:729
Mass (Da):79,907
Last modified:July 1, 2008 - v1
Checksum:i9C6C92EB95411F44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA. Translation: CAO96454.1.
RefSeqiWP_012441148.1. NC_010694.1.

Genome annotation databases

EnsemblBacteriaiCAO96454; CAO96454; ETA_14080.
KEGGieta:ETA_14080.
PATRICi20428576. VBIErwTas9546_1464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA. Translation: CAO96454.1.
RefSeqiWP_012441148.1. NC_010694.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi465817.ETA_14080.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAO96454; CAO96454; ETA_14080.
KEGGieta:ETA_14080.
PATRICi20428576. VBIErwTas9546_1464.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciETAS465817:GI36-1463-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia."
    Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K.
    Environ. Microbiol. 10:2211-2222(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17950 / CIP 109463 / Et1/99.

Entry informationi

Entry nameiKATG_ERWT9
AccessioniPrimary (citable) accession number: B2VFG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 1, 2008
Last modified: July 6, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.