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Protein

NAD kinase

Gene

nadK

Organism
Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Proton acceptorUniRule annotation1
Binding sitei158NADUniRule annotation1
Binding sitei175NADUniRule annotation1
Binding sitei177NADUniRule annotation1
Binding sitei247NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi73 – 74NADUniRule annotation2
Nucleotide bindingi147 – 148NADUniRule annotation2
Nucleotide bindingi188 – 193NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:ETA_09770
OrganismiErwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Taxonomic identifieri465817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeErwinia
Proteomesi
  • UP000001726 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001208601 – 292NAD kinaseAdd BLAST292

Interactioni

Protein-protein interaction databases

STRINGi465817.ETA_09770.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
HOGENOMiHOG000227221.
KOiK00858.
OMAiKLHWHEY.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

B2VEC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKPFSCIGI VGHPRHPTAL TTHEMLYRWL TAKGYQVIIE QQIARELKLE
60 70 80 90 100
GVQTGTLAEI GRTADLAVVV GGDGNMLGAA RVLARYDIKV IGINRGNLGF
110 120 130 140 150
LTDLDPDNAQ QQLADVLEGD YFVESRFLLE AQVCRQSGTP RIGTAINEVV
160 170 180 190 200
LHPGKVAHMI EFEVYIDENF AFSQRSDGLI ISTPTGSTAY SLSAGGPILT
210 220 230 240 250
PSLDAIALVP MFPHTLSARP LVINSSSTIR LRFSHMRSDL EISCDSQIAL
260 270 280 290
PIQQSEDVLI RRSDYHLNLI HPKNYNYFNT LSSKLGWSKK LF
Length:292
Mass (Da):32,250
Last modified:July 1, 2008 - v1
Checksum:iC76E1DC1BA6C79DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA. Translation: CAO96023.1.
RefSeqiWP_012440724.1. NC_010694.1.

Genome annotation databases

EnsemblBacteriaiCAO96023; CAO96023; ETA_09770.
KEGGieta:ETA_09770.
PATRICi20427660. VBIErwTas9546_1017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA. Translation: CAO96023.1.
RefSeqiWP_012440724.1. NC_010694.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi465817.ETA_09770.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAO96023; CAO96023; ETA_09770.
KEGGieta:ETA_09770.
PATRICi20427660. VBIErwTas9546_1017.

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
HOGENOMiHOG000227221.
KOiK00858.
OMAiKLHWHEY.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADK_ERWT9
AccessioniPrimary (citable) accession number: B2VEC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: November 30, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.