Reviewed, UniProtKB/Swiss-Prot B2VDM3 (NAGZ_ERWT9)

Names and origin

Protein names

Recommended name:
    Beta-hexosaminidase
    EC=3.2.1.52
Alternative name(s):
    N-acetyl-beta-glucosaminidase
    Beta-N-acetylhexosaminidase

Gene names

Name:	nagZ
Ordered Locus Names:	ETA_20090

Organism

Erwinia tasmaniensis (strain DSM 17950 / Et1/99) [Complete proteome] [HAMAP]

Taxonomic identifier

338565 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Erwinia

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides By similarity. HAMAP MF_00364
Catalytic activity	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP MF_00364
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP MF_00364
Subcellular location	Cytoplasm By similarity HAMAP MF_00364.
Sequence similarities	Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Beta-hexosaminidase HAMAP MF_00364		PRO_1000121061
Sites
	Active site	248	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2VDM3-1 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: C04A9677E8D6563F	FASTA	343	37,958
	10 20 30 40 50 60 MGPVMLDVLG CELDAEEREI LQHPLTGGLI LFSRNYHDPA QLRELVRQIR AASRHRLVVA 70 80 90 100 110 120 VDQEGGRVQR FREGFTRLPA MQAFSALNPS AEAETLAQQA GWLMASEMIA MDIDISFAPV 130 140 150 160 170 180 LDIGYGSAAI GERSFHEDPA IALQMARCFI RGMREAGMKT TGKHFPGHGA VSADSHKETP 190 200 210 220 230 240 RDTRSEAEIR RHDMPIFQQL IAERALDAIM PAHVIYTEVD PRPASGSSHW LKTVLRQELG 250 260 270 280 290 300 FDGVIFSDDL SMEGAAIMGS YAERGQAALD AGCDMILVCN NREGAVSVLD NLPAMEADRV 310 320 330 340 ARLYHRGDFT RQQLIDSSRW KETSVALDRL QGRWLNHKAA AGR

References

[1]

"The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia." Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K. Environ. Microbiol. 10:2211-2222(2008) [PubMed: 18462403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU468135 Genomic DNA. Translation: CAO97055.1.
RefSeq	YP_001907938.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6299458.
GenomeReviews	Gene locus ETA_20090 in contig CU468135_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG617255.
OMA	VERSIRM.
Family and domain databases
HAMAP	MF_00364. NagZ. [Tree]
InterPro	IPR019800. Glyco_hydro_3_AS. IPR001764. Glyco_hydro_3_N. IPR017853. Glyco_hydro_catalytic_core. [Graphical view]
Gene3D	G3DSA:3.20.20.300. Glyco_hydro_3_N. 1 hit.
Pfam	PF00933. Glyco_hydro_3. 1 hit. [Graphical view]
PROSITE	PS00775. GLYCOSYL_HYDROL_F3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGZ_ERWT9

Accession

Primary (citable) accession number: B2VDM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 1, 2008
Last modified:	January 19, 2010
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)