B2VCH7 (MTLD_ERWT9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	ETA_34190

Organism

Erwinia tasmaniensis (strain DSM 17950 / Et1/99) [Complete proteome] [HAMAP]

Taxonomic identifier

338565 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Erwinia

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000099192
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2VCH7 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 45104C836AD4D935	FASTA	382	41,195
	10 20 30 40 50 60 MKALHFGAGN IGRGFIGKLL ADAGVQLTFA DVNQAVLDAL NARGTYPVHV VGEQAQIEIV 70 80 90 100 110 120 NGVNAVHSSS DDIIALIAEV DIVTTAVGPQ ILERIAAGMA QGIAKRSDNA NSRPLNIIAC 130 140 150 160 170 180 ENMVRGTTQL KAHVLKALPE RYHAWLEEHV GFVDSAVDRI VPPSAADSSD PLEVTVETFS 190 200 210 220 230 240 EWIVDKTQFK GEPPTIPGME LTDNLMAFVE RKLFTLNTGH AIAAYLGQLA GHKTIREAIM 250 260 270 280 290 300 DKKVRAIVQG AMEESGAVLI KRYGFAADKH AAYIQKIINR FENPYLIDDV ERVGRQPLRK 310 320 330 340 350 360 LSAGDRLIKP TLGTLEYHLP NNNLVTGIAA ALLYRNEGDP QAIELAGLLS RQDVATTLVH 370 380 ISGLDKDSDV VKAVVKAVNA LA

References

[1]

"The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia." Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K. Environ. Microbiol. 10:2211-2222(2008) [PubMed: 18462403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17950 / Et1/99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU468135 Genomic DNA. Translation: CAO98465.1.
RefSeq	YP_001909325.1. NC_010694.1.
3D structure databases
ProteinModelPortal	B2VCH7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6299408.
GenomeReviews	Gene locus ETA_34190 in contig CU468135_GR.
PATRIC	20432765. VBIErwTas9546_3509.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG568825.
OMA	WIVNINQ.
ProtClustDB	PRK02318.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR023027. Mannitol_DH_CS. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_ERWT9

Accession

Primary (citable) accession number: B2VCH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program