Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:ETA_21230
OrganismiErwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Taxonomic identifieri465817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeErwinia
Proteomesi
  • UP000001726 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001294731 – 401Nicotinate phosphoribosyltransferaseAdd BLAST401

Proteomic databases

PRIDEiB2VC92

Interactioni

Protein-protein interaction databases

STRINGi465817.ETA_21230

Structurei

3D structure databases

ProteinModelPortaliB2VC92
SMRiB2VC92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284928
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG091H0197

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

B2VC92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRHAAPILT TLLDTDAYKL HMQQAVFHRY YDVTVTAEFR CRGEDMLGIY
60 70 80 90 100
ADELVQQIAN MASLTLTDNE FAYLSSLPFF KTDYLNWLRT FRYNPEQVTV
110 120 130 140 150
QNLQGKLDIR ISGPWREVIL WEVPLLALIS EVVHRHRSPQ ITPEQAVSRL
160 170 180 190 200
KSKLEQFKRL TCDLDMSRFR LMDFGTRRRF SHDVQLAVVS TLKQDFPWLV
210 220 230 240 250
GSSNYDIARR LNIAPVGTQA HEWFQAHQQI SPTLENCQRA ALQAWLDEYP
260 270 280 290 300
DRLGIALTDC ITTDAFLRDF GSEFAHAYQG LRHDSGDPFE WGEKAIAHYQ
310 320 330 340 350
QLNIDPLSKT LVFSDNLDLD KAVGLYRHFE QRINVIFGIG TRLSCDIPQV
360 370 380 390 400
KPLNIVIKLV ECNGKPVAKL SDSPGKTICH DKAFVRALRK AFDLPRVKKA

S
Length:401
Mass (Da):46,055
Last modified:July 1, 2008 - v1
Checksum:i9B5B884278C4F1F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA Translation: CAO97169.1
RefSeqiWP_012441840.1, NC_010694.1

Genome annotation databases

EnsemblBacteriaiCAO97169; CAO97169; ETA_21230
KEGGieta:ETA_21230

Similar proteinsi

Entry informationi

Entry nameiPNCB_ERWT9
AccessioniPrimary (citable) accession number: B2VC92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health