B2VC92 (PNCB_ERWT9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	ETA_21230

Organism

Erwinia tasmaniensis (strain DSM 17950 / Et1/99) [Complete proteome] [HAMAP]

Taxonomic identifier

338565 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Erwinia

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570		PRO_1000129473

Sequences

	Sequence		Length	Mass (Da)
	B2VC92 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 9B5B884278C4F1F0	FASTA	401	46,055
	10 20 30 40 50 60 MTRHAAPILT TLLDTDAYKL HMQQAVFHRY YDVTVTAEFR CRGEDMLGIY ADELVQQIAN 70 80 90 100 110 120 MASLTLTDNE FAYLSSLPFF KTDYLNWLRT FRYNPEQVTV QNLQGKLDIR ISGPWREVIL 130 140 150 160 170 180 WEVPLLALIS EVVHRHRSPQ ITPEQAVSRL KSKLEQFKRL TCDLDMSRFR LMDFGTRRRF 190 200 210 220 230 240 SHDVQLAVVS TLKQDFPWLV GSSNYDIARR LNIAPVGTQA HEWFQAHQQI SPTLENCQRA 250 260 270 280 290 300 ALQAWLDEYP DRLGIALTDC ITTDAFLRDF GSEFAHAYQG LRHDSGDPFE WGEKAIAHYQ 310 320 330 340 350 360 QLNIDPLSKT LVFSDNLDLD KAVGLYRHFE QRINVIFGIG TRLSCDIPQV KPLNIVIKLV 370 380 390 400 ECNGKPVAKL SDSPGKTICH DKAFVRALRK AFDLPRVKKA S

References

[1]

"The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia." Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K. Environ. Microbiol. 10:2211-2222(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 17950 / Et1/99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU468135 Genomic DNA. Translation: CAO97169.1.
RefSeq	YP_001908047.1. NC_010694.1.
3D structure databases
ProteinModelPortal	B2VC92.
ModBase	Search...
Protein-protein interaction databases
STRING	465817.ETA_21230.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAO97169; CAO97169; ETA_21230.
GeneID	6299581.
KEGG	eta:ETA_21230.
PATRIC	20430083. VBIErwTas9546_2205.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1488.
HOGENOM	HOG000284928.
KO	K00763.
OMA	SFGWGTN.
ProtClustDB	PRK05321.
Enzyme and pathway databases
BioCyc	ETAS465817:GI36-2815-MONOMER.
UniPathway	UPA00253; UER00457.
Family and domain databases
HAMAP	MF_00570. NAPRTase.
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
PANTHER	PTHR11098:SF1. PTHR11098:SF1. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_ERWT9

Accession

Primary (citable) accession number: B2VC92

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 1, 2008
Last modified:	May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program