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B2VC08 (HUTI_ERWT9) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Imidazolonepropionase
EC=3.5.2.7
Alternative name(s):
Imidazolone-5-propionate hydrolase
Gene names
Name:hutI
Ordered Locus Names:ETA_22200
OrganismErwinia tasmaniensis (strain DSM 17950 / Et1/99) [Complete proteome] [HAMAP]
Taxonomic identifier338565 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Erwinia

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+. HAMAP MF_00372

Cofactor

Binds 1 zinc or iron ion per subunit By similarity. HAMAP MF_00372

Pathway

Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. HAMAP MF_00372

Subcellular location

Cytoplasm Potential HAMAP MF_00372.

Sequence similarities

Belongs to the HutI family.

Ontologies

Keywords
   Biological processHistidine metabolism
   Cellular componentCytoplasm
   LigandIron
Metal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processhistidine catabolic process to glutamate and formamide

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionimidazolonepropionase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 405405Imidazolonepropionase HAMAP MF_00372
PRO_1000121542

Sites

Metal binding721Zinc or iron By similarity
Metal binding741Zinc or iron By similarity
Metal binding2421Zinc or iron By similarity
Metal binding3171Zinc or iron By similarity
Binding site811Substrate By similarity
Binding site941Substrate By similarity
Binding site1441Substrate By similarity
Binding site1771Substrate By similarity
Binding site2451Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B2VC08 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 8FF2AD6996BEBF8A

FASTA40543,695
        10         20         30         40         50         60 
MNQQLSCDHL WFGADIVTMQ NGRYGIIEQG AIAVSGQQII WVGPYADSAH IQARQRTDLG 

        70         80         90        100        110        120 
GGIVTPGLVD CHTHLVFGGD RSDEFEQRLN GVSYSEIAAQ VGGILATVRA TRSASQAELV 

       130        140        150        160        170        180 
DAARQRLQHL LAEGVTTVEI KSGYGLEVAS ELRMLQAIRQ LAQQVPAQIQ ATCLAAHAVP 

       190        200        210        220        230        240 
PEYRHDPEAW VDVICDQLLP QVAAEGLADA VDAFCEHLAF SPDQVRRVFI AAKALGFALK 

       250        260        270        280        290        300 
LHAEQLSSLG GSALAAEFDA LSADHVEYAT ESDVAAMAQH GTVAVLLPGA FYLLREKQRP 

       310        320        330        340        350        360 
PVELFRRYQV PMALASDANP GTSPALSLRL MMNMGCTLFG MTPEEALAGV TLHAARALGL 

       370        380        390        400 
AQRIGSLESG KMADFVHWPL ARPAELVYWL GGQLPCRVIF RGEER

« Hide

References

[1]"The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia."
Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K.
Environ. Microbiol. 10:2211-2222(2008) [PubMed: 18462403] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17950 / Et1/99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU468135 Genomic DNA. Translation: CAO97266.1.
RefSeqYP_001908144.1. NC_010694.1.

3D structure databases

ProteinModelPortalB2VC08.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6299171.
GenomeReviewsGene locus ETA_22200 in contig CU468135_GR.
PATRIC20430283. VBIErwTas9546_2305.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG686142.
OMAMNMACTL.
ProtClustDBPRK09356.

Family and domain databases

HAMAPMF_00372. HutI.
[Tree]
InterProIPR013108. Amidohydro_3.
IPR005920. HutI.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
PANTHERPTHR22642. PTHR22642. 1 hit.
PfamPF07969. Amidohydro_3. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR01224. HutI. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHUTI_ERWT9
AccessionPrimary (citable) accession number: B2VC08
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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