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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
Ordered Locus Names:ETA_22700
OrganismiErwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Taxonomic identifieri465817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeErwinia
Proteomesi
  • UP000001726 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001481581 – 3306-phosphogluconolactonaseAdd BLAST330

Interactioni

Protein-protein interaction databases

STRINGi465817.ETA_22700

Structurei

3D structure databases

ProteinModelPortaliB2VBU3
SMRiB2VBU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105HHQ Bacteria
COG2706 LUCA
HOGENOMiHOG000257418
KOiK07404
OMAiEGNWPRD
OrthoDBiPOG091H07R3

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_01605 6P_gluconolactonase, 1 hit
InterProiView protein in InterPro
IPR022528 6-phosphogluconolactonase_YbhE
IPR019405 Lactonase_7-beta_prop
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit
SUPFAMiSSF50974 SSF50974, 1 hit

Sequencei

Sequence statusi: Complete.

B2VBU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQVVYTASP ESQQIHAWQL NNEGALTLLQ VVDAPGQVQP MVVSPDKSFL
60 70 80 90 100
YVGVRPDFRV VAYQIDAEGK LKEAGHAPLP GSPTHISTDR QGRFIFVGSY
110 120 130 140 150
NDACVSVTPI GENGLPGEPL QVVKGLEGCH SANIDLNNQT LFVPALKQDR
160 170 180 190 200
IALFSLDKQG KLTPRAQAEV KTRSGAGPRH MAFHPNQRYA YSVNELDSSV
210 220 230 240 250
DVWDISGDEV KKVQSVDALP EGFSDTRWAA DIHITPDGRH LYSCDRTASN
260 270 280 290 300
ITIFSISAEG SSLKVEGYQP TETQPRGFNI DHSGQYLVAA GQKSHHIEVY
310 320 330
KISADRGLLQ PLARYAVGQG PMWVVINKLD
Length:330
Mass (Da):36,085
Last modified:July 1, 2008 - v1
Checksum:i958312E7CDC42D57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA Translation: CAO97316.1
RefSeqiWP_012441985.1, NC_010694.1

Genome annotation databases

EnsemblBacteriaiCAO97316; CAO97316; ETA_22700
KEGGieta:ETA_22700

Similar proteinsi

Entry informationi

Entry namei6PGL_ERWT9
AccessioniPrimary (citable) accession number: B2VBU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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