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Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei80UniRule annotation1
Active sitei143UniRule annotation1
Active sitei165UniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC15.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidaseUniRule annotation (EC:3.4.19.3UniRule annotation)
Alternative name(s):
5-oxoprolyl-peptidaseUniRule annotation
Pyroglutamyl-peptidase IUniRule annotation
Short name:
PGP-IUniRule annotation
Short name:
PyraseUniRule annotation
Gene namesi
Name:pcpUniRule annotation
Ordered Locus Names:ETA_23110
OrganismiErwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Taxonomic identifieri465817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeErwinia
Proteomesi
  • UP000001726 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001239951 – 213Pyrrolidone-carboxylate peptidaseAdd BLAST213

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi465817.ETA_23110.

Structurei

3D structure databases

ProteinModelPortaliB2VBP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108KN7. Bacteria.
COG2039. LUCA.
HOGENOMiHOG000242641.
KOiK01304.
OMAiVCNHIMY.
OrthoDBiPOG091H07B8.

Family and domain databases

CDDicd00501. Peptidase_C15. 1 hit.
Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase. 1 hit.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
IPR033694. PGPEP1_Cys_AS.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2VBP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVLITAFE PFDGERINPS WEAVSRLHNR LIGGAEIVAK RLPCAFGTSL
60 70 80 90 100
EVLYATIDAV KPDLVIAVGQ AGGRADMSIE RVAINVDDAR IPDNAGAQPI
110 120 130 140 150
DEPVLSGGPA ALFSTLPIKA LVAGIREAGI PASVSQTAGT FVCNHVMYGL
160 170 180 190 200
LHYLRRRKAR GGFIHIPYLP EQAINHPGAP SMALATVILA LEMAVSISLA
210
VEEDMRLAGG ATH
Length:213
Mass (Da):22,537
Last modified:July 1, 2008 - v1
Checksum:iAED274608E1F06B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA. Translation: CAO97357.1.
RefSeqiWP_012442026.1. NC_010694.1.

Genome annotation databases

EnsemblBacteriaiCAO97357; CAO97357; ETA_23110.
KEGGieta:ETA_23110.
PATRICi20430473. VBIErwTas9546_2394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA. Translation: CAO97357.1.
RefSeqiWP_012442026.1. NC_010694.1.

3D structure databases

ProteinModelPortaliB2VBP1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi465817.ETA_23110.

Protein family/group databases

MEROPSiC15.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAO97357; CAO97357; ETA_23110.
KEGGieta:ETA_23110.
PATRICi20430473. VBIErwTas9546_2394.

Phylogenomic databases

eggNOGiENOG4108KN7. Bacteria.
COG2039. LUCA.
HOGENOMiHOG000242641.
KOiK01304.
OMAiVCNHIMY.
OrthoDBiPOG091H07B8.

Family and domain databases

CDDicd00501. Peptidase_C15. 1 hit.
Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase. 1 hit.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
IPR033694. PGPEP1_Cys_AS.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCP_ERWT9
AccessioniPrimary (citable) accession number: B2VBP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: November 30, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.