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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei622ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:ETA_23470
OrganismiErwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Taxonomic identifieri465817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeErwinia
Proteomesi
  • UP000001726 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913171 – 860Leucine--tRNA ligaseAdd BLAST860

Proteomic databases

PRIDEiB2VBM4

Interactioni

Protein-protein interaction databases

STRINGi465817.ETA_23470

Structurei

3D structure databases

ProteinModelPortaliB2VBM4
SMRiB2VBM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi619 – 623"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B2VBM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEQYRPEEI ESNVQQHWDE KQTFKVTEDE GKEKYYCLSM LPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VISRYQRMLG KNVLQPIGWD AFGLPAEGAA VKNNTAPAPW
110 120 130 140 150
TYANIDYMKN QLKLLGFGYD WNRELATCQP EYYRWEQWFF TKLYEKGLVY
160 170 180 190 200
KKTSAVNWCP HDMTVLANEQ VIDGCCWRCD SKVERKEIPQ WFVKITDYAD
210 220 230 240 250
ELLNDLDKLE SWPEQVKTMQ RNWIGRSEGV EIEFTVLNSE EKLSVYTTRP
260 270 280 290 300
DTFMGVTYLA VAAGHPLAAQ AALNNPALAD FIAECRNTKV AEADMATMEK
310 320 330 340 350
KGMATGLFAA HPLTGEKVPV WVANFVLMEY GTGAVMAVPG HDQRDWEFAS
360 370 380 390 400
KYSLPIKPVI LAADGSEPDL SGSAMTEKGT LFNSGEFDGL SHEAGFDAIA
410 420 430 440 450
AKLADKGVGE RKVNYRLRDW GVSRQRYWGA PIPMVTLEDG TVMPTPEDQL
460 470 480 490 500
PVILPEDVVM DGITSPIKAD AEWAKTTVNG QPALRETDTF DTFMESSWYY
510 520 530 540 550
ARYTCPNYDK GMLDPAAANY WLPVDQYVGG IEHAIMHLLY FRFFHKLLRD
560 570 580 590 600
TGLVNSDEPA KRLLCQGMVL ADAFYFTGSN GERNWVSPTD VSVERDEKGR
610 620 630 640 650
ITKATDNDGN ELIYAGMSKM SKSKNNGIDP QVMVERYGAD TVRLFMMFAS
660 670 680 690 700
PAEMTLEWQE SGVEGANRFL KRVWRLAFEH TEKGPTVALD LDALNDEQKA
710 720 730 740 750
LRRDLHKTIS KVSDDIGRRQ TFNTAIAAIM ELMNKLARAP QETEQDRALM
760 770 780 790 800
QEALLAVVRM LNPFTPHASF VLWQALGGAG EIDNAPWPQA EEAAMVEDSL
810 820 830 840 850
LVVVQVNGKV RGKITVAADA TQEQVQARAA QEHLVAKYLD GVTIRKVIFV
860
PGKLLNLVVG
Length:860
Mass (Da):96,742
Last modified:July 1, 2008 - v1
Checksum:iEE1F9F215ED7E12F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU468135 Genomic DNA Translation: CAO97393.1
RefSeqiWP_012442062.1, NC_010694.1

Genome annotation databases

EnsemblBacteriaiCAO97393; CAO97393; ETA_23470
KEGGieta:ETA_23470

Similar proteinsi

Entry informationi

Entry nameiSYL_ERWT9
AccessioniPrimary (citable) accession number: B2VBM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health