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B2VBM4

- SYL_ERWT9

UniProt

B2VBM4 - SYL_ERWT9

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Protein

Leucine--tRNA ligase

Gene
leuS, ETA_23470
Organism
Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciETAS465817:GI36-2427-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:ETA_23470
OrganismiErwinia tasmaniensis (strain DSM 17950 / Et1/99)
Taxonomic identifieri338565 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeErwinia
ProteomesiUP000001726: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Leucine--tRNA ligaseUniRule annotationPRO_1000091317Add
BLAST

Proteomic databases

PRIDEiB2VBM4.

Interactioni

Protein-protein interaction databases

STRINGi465817.ETA_23470.

Structurei

3D structure databases

ProteinModelPortaliB2VBM4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi619 – 6235"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2VBM4-1 [UniParc]FASTAAdd to Basket

« Hide

MQEQYRPEEI ESNVQQHWDE KQTFKVTEDE GKEKYYCLSM LPYPSGRLHM    50
GHVRNYTIGD VISRYQRMLG KNVLQPIGWD AFGLPAEGAA VKNNTAPAPW 100
TYANIDYMKN QLKLLGFGYD WNRELATCQP EYYRWEQWFF TKLYEKGLVY 150
KKTSAVNWCP HDMTVLANEQ VIDGCCWRCD SKVERKEIPQ WFVKITDYAD 200
ELLNDLDKLE SWPEQVKTMQ RNWIGRSEGV EIEFTVLNSE EKLSVYTTRP 250
DTFMGVTYLA VAAGHPLAAQ AALNNPALAD FIAECRNTKV AEADMATMEK 300
KGMATGLFAA HPLTGEKVPV WVANFVLMEY GTGAVMAVPG HDQRDWEFAS 350
KYSLPIKPVI LAADGSEPDL SGSAMTEKGT LFNSGEFDGL SHEAGFDAIA 400
AKLADKGVGE RKVNYRLRDW GVSRQRYWGA PIPMVTLEDG TVMPTPEDQL 450
PVILPEDVVM DGITSPIKAD AEWAKTTVNG QPALRETDTF DTFMESSWYY 500
ARYTCPNYDK GMLDPAAANY WLPVDQYVGG IEHAIMHLLY FRFFHKLLRD 550
TGLVNSDEPA KRLLCQGMVL ADAFYFTGSN GERNWVSPTD VSVERDEKGR 600
ITKATDNDGN ELIYAGMSKM SKSKNNGIDP QVMVERYGAD TVRLFMMFAS 650
PAEMTLEWQE SGVEGANRFL KRVWRLAFEH TEKGPTVALD LDALNDEQKA 700
LRRDLHKTIS KVSDDIGRRQ TFNTAIAAIM ELMNKLARAP QETEQDRALM 750
QEALLAVVRM LNPFTPHASF VLWQALGGAG EIDNAPWPQA EEAAMVEDSL 800
LVVVQVNGKV RGKITVAADA TQEQVQARAA QEHLVAKYLD GVTIRKVIFV 850
PGKLLNLVVG 860
Length:860
Mass (Da):96,742
Last modified:July 1, 2008 - v1
Checksum:iEE1F9F215ED7E12F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU468135 Genomic DNA. Translation: CAO97393.1.
RefSeqiYP_001908271.1. NC_010694.1.

Genome annotation databases

EnsemblBacteriaiCAO97393; CAO97393; ETA_23470.
GeneIDi6300353.
KEGGieta:ETA_23470.
PATRICi20430559. VBIErwTas9546_2431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU468135 Genomic DNA. Translation: CAO97393.1 .
RefSeqi YP_001908271.1. NC_010694.1.

3D structure databases

ProteinModelPortali B2VBM4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 465817.ETA_23470.

Proteomic databases

PRIDEi B2VBM4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAO97393 ; CAO97393 ; ETA_23470 .
GeneIDi 6300353.
KEGGi eta:ETA_23470.
PATRICi 20430559. VBIErwTas9546_2431.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ETAS465817:GI36-2427-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic bacterium in the genus Erwinia."
    Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R., Geider K.
    Environ. Microbiol. 10:2211-2222(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17950 / Et1/99.

Entry informationi

Entry nameiSYL_ERWT9
AccessioniPrimary (citable) accession number: B2VBM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi