B2V9P8 (SYGA_SULSY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycine--tRNA ligase alpha subunit
EC=6.1.1.14

Alternative name(s):
Glycyl-tRNA synthetase alpha subunit
Short name=GlyRS

Gene names

Name:	glyQ
Ordered Locus Names:	SYO3AOP1_1052

Organism

Sulfurihydrogenibium sp. (strain YO3AOP1) [Complete proteome] [HAMAP]

Taxonomic identifier

436114 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Hydrogenothermaceae › Sulfurihydrogenibium

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). HAMAP MF_00254
Subunit structure	Tetramer of two alpha and two beta subunits By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_00254.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Glycine--tRNA ligase alpha subunit HAMAP MF_00254		PRO_1000101240

Sequences

	Sequence		Length	Mass (Da)
	B2V9P8 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 67125AB1E219D99E	FASTA	297	34,629
	10 20 30 40 50 60 MTFQDIIMTL QKFWVEKGCI LWQPYDIEVG AGTMNPATFL RVLGPEPWNV CYVEPSRRPK 70 80 90 100 110 120 DGRYGENPNR LQHYYQFQVI LKPTPENPHE LYLESLQALG IDLTMHDIRF VEDDWESPTL 130 140 150 160 170 180 GAWGLGWEVW LDGMEITQFT YFQQAGSLDL PEISVEITYG LERIATYLQG KDSVYDIVWA 190 200 210 220 230 240 EGLTYGDIYK EAERQWSIHN FEVVDVDFLI KTFDMYEQEG YKLISLNLPI PAYDYALKCS 250 260 270 280 290 HTFNLLDARG ALSVNERARY IARVRNLARE CAKAFVKHRE ELGYPLIKRR DDEVLST

References

[1]

"Complete and draft genome sequences of six members of the Aquificales." Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A. J. Bacteriol. 191:1992-1993(2009) [PubMed: 19136599] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YO3AOP1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001080 Genomic DNA. Translation: ACD66671.1.
RefSeq	YP_001931225.1. NC_010730.1.
3D structure databases
ProteinModelPortal	B2V9P8.
SMR	B2V9P8. Positions 1-277.
ModBase	Search...
Protein-protein interaction databases
STRING	B2V9P8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6332783.
GenomeReviews	Gene locus SYO3AOP1_1052 in contig CP001080_GR.
KEGG	sul:SYO3AOP1_1052.
PATRIC	23766931. VBISulSp94719_1096.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285316.
OMA	CRRPTDG.
ProtClustDB	PRK09348.
Family and domain databases
HAMAP	MF_00254. Gly_tRNA_synth_alpha. [Tree]
InterPro	IPR006194. Gly-tRNA-synth_II_heterodimer. IPR002310. Gly-tRNA_synth_IIc_asu. [Graphical view]
KO	K01878.
Pfam	PF02091. tRNA-synt_2e. 1 hit. [Graphical view]
PRINTS	PR01044. TRNASYNTHGA.
TIGRFAMs	TIGR00388. GlyQ. 1 hit.
PROSITE	PS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYGA_SULSY

Accession

Primary (citable) accession number: B2V9P8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program