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Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Sulfurihydrogenibium sp. (strain YO3AOP1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).By similarity

Miscellaneous

The active site is located at the dimer interface.By similarity

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Pathwayi: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.By similarity
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 4-hydroxythreonine-4-phosphate dehydrogenase (pdxA)
  5. Pyridoxine 5'-phosphate synthase (pdxJ)
This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei131SubstrateBy similarity1
Binding sitei132SubstrateBy similarity1
Metal bindingi161Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi206Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi259Divalent metal cation; shared with dimeric partnerBy similarity1
Binding sitei267SubstrateBy similarity1
Binding sitei276SubstrateBy similarity1
Binding sitei285SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridoxine biosynthesis
LigandMetal-binding, NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenaseBy similarity (EC:1.1.1.262By similarity)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenaseBy similarity
Gene namesi
Name:pdxABy similarity
Ordered Locus Names:SYO3AOP1_0946
OrganismiSulfurihydrogenibium sp. (strain YO3AOP1)
Taxonomic identifieri436114 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
Proteomesi
  • UP000001201 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001464931 – 3224-hydroxythreonine-4-phosphate dehydrogenaseAdd BLAST322

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi436114.SYO3AOP1_0946.

Structurei

3D structure databases

ProteinModelPortaliB2V9E6.
SMRiB2V9E6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.Curated

Phylogenomic databases

eggNOGiENOG4105CEZ. Bacteria.
COG1995. LUCA.
HOGENOMiHOG000221591.
KOiK00097.
OMAiLTIHIPY.
OrthoDBiPOG091H03XD.

Family and domain databases

InterProiView protein in InterPro
IPR005255. PdxA.
PANTHERiPTHR30004. PTHR30004. 1 hit.
PfamiView protein in Pfam
PF04166. PdxA. 1 hit.
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

B2V9E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLAITLGD PSGINSEILL KALNKLPKRN ISYVIYGSKK ALEKAKKLTG
60 70 80 90 100
VDLNIKEIKS INDVVKSGIY LINLYDLDVE FGSSSKETGK ASVVYLENAV
110 120 130 140 150
KDVLEKKADA LITLPISKQW IMESGFPYAG HTDYLAEVSG AKEYAMVLMC
160 170 180 190 200
KKLKVALITT HIPLKDVPSQ ITKEKIISKV RLINREFKEK FGISKPKIAI
210 220 230 240 250
LGLNPHASDN GNIGNEEQNI ILPAVKTLRE DGIEITDPLS PDTAFNRYKD
260 270 280 290 300
FDIYVAMYHD QGLIPLKLLC FRKAVNITLG LPFIRTSPDH GTGYDIAGKN
310 320
IADPSSTIEA VELAILLKRV RK
Length:322
Mass (Da):35,609
Last modified:July 1, 2008 - v1
Checksum:iB5AFA28A3EAECBEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001080 Genomic DNA. Translation: ACD66569.1.
RefSeqiWP_012459640.1. NC_010730.1.

Genome annotation databases

EnsemblBacteriaiACD66569; ACD66569; SYO3AOP1_0946.
KEGGisul:SYO3AOP1_0946.
PATRICi23766709. VBISulSp94719_0986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001080 Genomic DNA. Translation: ACD66569.1.
RefSeqiWP_012459640.1. NC_010730.1.

3D structure databases

ProteinModelPortaliB2V9E6.
SMRiB2V9E6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi436114.SYO3AOP1_0946.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD66569; ACD66569; SYO3AOP1_0946.
KEGGisul:SYO3AOP1_0946.
PATRICi23766709. VBISulSp94719_0986.

Phylogenomic databases

eggNOGiENOG4105CEZ. Bacteria.
COG1995. LUCA.
HOGENOMiHOG000221591.
KOiK00097.
OMAiLTIHIPY.
OrthoDBiPOG091H03XD.

Enzyme and pathway databases

UniPathwayiUPA00244; UER00312.

Family and domain databases

InterProiView protein in InterPro
IPR005255. PdxA.
PANTHERiPTHR30004. PTHR30004. 1 hit.
PfamiView protein in Pfam
PF04166. PdxA. 1 hit.
TIGRFAMsiTIGR00557. pdxA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPDXA_SULSY
AccessioniPrimary (citable) accession number: B2V9E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 1, 2008
Last modified: May 10, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.