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B2V9E6

- PDXA_SULSY

UniProt

B2V9E6 - PDXA_SULSY

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Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Sulfurihydrogenibium sp. (strain YO3AOP1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei131 – 1311SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Metal bindingi161 – 1611Divalent metal cation; shared with dimeric partnerUniRule annotation
Metal bindingi206 – 2061Divalent metal cation; shared with dimeric partnerUniRule annotation
Metal bindingi259 – 2591Divalent metal cation; shared with dimeric partnerUniRule annotation
Binding sitei267 – 2671SubstrateUniRule annotation
Binding sitei276 – 2761SubstrateUniRule annotation
Binding sitei285 – 2851SubstrateUniRule annotation

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD binding Source: InterPro

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, NADP

Enzyme and pathway databases

BioCyciSSP436114:GI6I-989-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
Gene namesi
Name:pdxAUniRule annotation
Ordered Locus Names:SYO3AOP1_0946
OrganismiSulfurihydrogenibium sp. (strain YO3AOP1)
Taxonomic identifieri436114 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
ProteomesiUP000001201: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3223224-hydroxythreonine-4-phosphate dehydrogenasePRO_1000146493Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi436114.SYO3AOP1_0946.

Structurei

3D structure databases

ProteinModelPortaliB2V9E6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221591.
KOiK00097.
OMAiAPINKHN.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

B2V9E6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKLAITLGD PSGINSEILL KALNKLPKRN ISYVIYGSKK ALEKAKKLTG
60 70 80 90 100
VDLNIKEIKS INDVVKSGIY LINLYDLDVE FGSSSKETGK ASVVYLENAV
110 120 130 140 150
KDVLEKKADA LITLPISKQW IMESGFPYAG HTDYLAEVSG AKEYAMVLMC
160 170 180 190 200
KKLKVALITT HIPLKDVPSQ ITKEKIISKV RLINREFKEK FGISKPKIAI
210 220 230 240 250
LGLNPHASDN GNIGNEEQNI ILPAVKTLRE DGIEITDPLS PDTAFNRYKD
260 270 280 290 300
FDIYVAMYHD QGLIPLKLLC FRKAVNITLG LPFIRTSPDH GTGYDIAGKN
310 320
IADPSSTIEA VELAILLKRV RK
Length:322
Mass (Da):35,609
Last modified:July 1, 2008 - v1
Checksum:iB5AFA28A3EAECBEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001080 Genomic DNA. Translation: ACD66569.1.
RefSeqiWP_012459640.1. NC_010730.1.
YP_001931123.1. NC_010730.1.

Genome annotation databases

EnsemblBacteriaiACD66569; ACD66569; SYO3AOP1_0946.
GeneIDi6331017.
KEGGisul:SYO3AOP1_0946.
PATRICi23766709. VBISulSp94719_0986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001080 Genomic DNA. Translation: ACD66569.1 .
RefSeqi WP_012459640.1. NC_010730.1.
YP_001931123.1. NC_010730.1.

3D structure databases

ProteinModelPortali B2V9E6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436114.SYO3AOP1_0946.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD66569 ; ACD66569 ; SYO3AOP1_0946 .
GeneIDi 6331017.
KEGGi sul:SYO3AOP1_0946.
PATRICi 23766709. VBISulSp94719_0986.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221591.
KOi K00097.
OMAi APINKHN.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci SSP436114:GI6I-989-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YO3AOP1.

Entry informationi

Entry nameiPDXA_SULSY
AccessioniPrimary (citable) accession number: B2V9E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 1, 2008
Last modified: November 26, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3