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B2V969 (FMT_SULSY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methionyl-tRNA formyltransferase

EC=2.1.2.9
Gene names
Name:fmt
Ordered Locus Names:SYO3AOP1_0864
OrganismSulfurihydrogenibium sp. (strain YO3AOP1) [Complete proteome] [HAMAP]
Taxonomic identifier436114 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity. HAMAP-Rule MF_00182

Catalytic activity

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet). HAMAP-Rule MF_00182

Sequence similarities

Belongs to the Fmt family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionmethionyl-tRNA formyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Methionyl-tRNA formyltransferase HAMAP-Rule MF_00182
PRO_1000098452

Regions

Region110 – 1134Tetrahydrofolate (THF) binding By similarity

Sequences

Sequence LengthMass (Da)Tools
B2V969 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: B225A628E31491E1

FASTA31134,979
        10         20         30         40         50         60 
MKVLFWGTPD FAVKSLKALI ESNHQVVGVI TQPDKPRGRG QKIQPTPVKE EALKHNIPVF 

        70         80         90        100        110        120 
QPEKIKNNQE ILETIKKLNP DISVVVAYGK ILPEEIINIP KYKTINVHAS LLPEYRGAAP 

       130        140        150        160        170        180 
IQRAIMEGKD KTGVCIMEII KELDAGDVYA CREVEITEDD DIISLHDKLA EEGARLLIKV 

       190        200        210        220        230        240 
LDKIEKGEID KKPQDHEKAT YAKPIEKSEG KIDFSRSAKE IFNQIRALKV WPKAYAKFRD 

       250        260        270        280        290        300 
EEVKILDAKI VECNLNALPG EIIKADEKEG IVVKTGDGCL LLKIIQFPNS KPITTQDAIR 

       310 
GYKIKAGERF E 

« Hide

References

[1]"Complete and draft genome sequences of six members of the Aquificales."
Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.
J. Bacteriol. 191:1992-1993(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YO3AOP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001080 Genomic DNA. Translation: ACD66492.1.
RefSeqYP_001931046.1. NC_010730.1.

3D structure databases

ProteinModelPortalB2V969.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING436114.SYO3AOP1_0864.

Proteomic databases

PRIDEB2V969.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD66492; ACD66492; SYO3AOP1_0864.
GeneID6331646.
KEGGsul:SYO3AOP1_0864.
PATRIC23766517. VBISulSp94719_0895.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0223.
HOGENOMHOG000261177.
KOK00604.
OMAVRGMNPF.
OrthoDBEOG6B09WV.
ProtClustDBCLSK2479570.

Enzyme and pathway databases

BioCycSSP436114:GI6I-902-MONOMER.

Family and domain databases

Gene3D3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPMF_00182. Formyl_trans.
InterProIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view]
PANTHERPTHR11138. PTHR11138. 1 hit.
PfamPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsTIGR00460. fmt. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFMT_SULSY
AccessionPrimary (citable) accession number: B2V969
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families