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B2V955 (HEMH_SULSY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:SYO3AOP1_0845
OrganismSulfurihydrogenibium sp. (strain YO3AOP1) [Complete proteome] [HAMAP]
Taxonomic identifier436114 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Hydrogenothermaceae › Sulfurihydrogenibium

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Ferrochelatase HAMAP MF_00323
PRO_1000116086

Sites

Metal binding2111Iron By similarity
Metal binding2901Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B2V955 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 510ABD71DD8189D8

FASTA33539,188
        10         20         30         40         50         60 
MTKEKIGVVL LNMGGPDSLD AIQPFLYNLF SDHDIIQIPK PIQKPVAFLI SRLRAKKTKK 

        70         80         90        100        110        120 
YYEIMGGKSP QKEQTLQQAQ KLQEKLEEDY KVVVAMRYWH PFTEEALNQL FQEKIKKIIL 

       130        140        150        160        170        180 
LPLYPQYSRT TTGSSFNEFD RRVKRYINPG KFAVLSTLKG TKDPYYYFSN IPIAKINCYF 

       190        200        210        220        230        240 
DNPLYIKAMV ENIKENLPED YKDYYFLFTA HSLPEKIILD GDPYKKQTET TVKLIMEHFP 

       250        260        270        280        290        300 
NVKYSLAYQS KVGPVKWLEP FTDQEIERLI KEGYKKLIVI PVSFVSEHSE TLYELDYLYG 

       310        320        330 
NIAKELGAES YIRIPTLKSH PMFIETLKEL VIKNS

« Hide

References

[1]"Complete and draft genome sequences of six members of the Aquificales."
Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.
J. Bacteriol. 191:1992-1993(2009) [PubMed: 19136599] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YO3AOP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001080 Genomic DNA. Translation: ACD66478.1.
RefSeqYP_001931032.1. NC_010730.1.

3D structure databases

ProteinModelPortalB2V955.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2V955.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6331222.
GenomeReviewsGene locus SYO3AOP1_0845 in contig CP001080_GR.
KEGGsul:SYO3AOP1_0845.
PATRIC23766469. VBISulSp94719_0871.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMALQKPLAW.
ProtClustDBCLSK2299560.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_SULSY
AccessionPrimary (citable) accession number: B2V955
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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