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B2V900

- PNP_SULSY

UniProt

B2V900 - PNP_SULSY

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Sulfurihydrogenibium sp. (strain YO3AOP1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi484 – 4841MagnesiumUniRule annotation
    Metal bindingi490 – 4901MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciSSP436114:GI6I-827-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:SYO3AOP1_0790
    OrganismiSulfurihydrogenibium sp. (strain YO3AOP1)
    Taxonomic identifieri436114 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
    ProteomesiUP000001201: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 703703Polyribonucleotide nucleotidyltransferasePRO_1000185758Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi436114.SYO3AOP1_0790.

    Structurei

    3D structure databases

    ProteinModelPortaliB2V900.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini551 – 61060KHUniRule annotationAdd
    BLAST
    Domaini620 – 68869S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218327.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2V900-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEIKIETVV NGAPYSIETG YFAKQANGAV IVRQGDTAVL VAAVMSEEPQ    50
    ADIDFLPLTV EYREKYYAYG KIPGGFVKRE GKPSEREILV ARNIDRPIRP 100
    LFPKGFYNDV IITAYTLSAD DQYDPDVLGI VGASAALHIS DIPFEGPIAG 150
    VRVCRVDGQF IVNPTYQQKA KSDLEIVVAG SKDAIVMVEG GAKEVPEEVI 200
    LEAMLFGHQE IKKLIELQEE LRAKYGKEKI EIPIDEEEIL LKEKFKELAY 250
    VRIKEAFNIS DKKERNKQIN AIFEEIKTTL EIPEEKVKKA SFVYKDVVSN 300
    VMRDLVLYEN IRIDGRKPEE IRPIWIKVGV FPRNHGSAIF TRGQTQAFVT 350
    VTLGSPSEGQ IEESIEAGET LKRFMLHYNF PPFSTGEAKP PRPVSRREIG 400
    HGNLAERALE PLIPSEEEFP YVIRVVSDIL ESNGSTSMAT VCGGSLALFD 450
    AGVPMKKHVA GIAMGLIKSE DKFVVLSDIL GDEDHLGDMD FKVAGTRDGV 500
    TSIQMDIKVK GLTREILQKA LEQAREGRNY ILDLMYQAIP EPRKELSPYA 550
    PTVTTLRVLP EKISVIIGPA GKNIKKIIEE TGVKIDLDPT GLVKIYATSK 600
    IAAEKAIDMI NQLIMDIELG EVYLGKVTRV EDYGAFVELM PGKLSLLHVS 650
    QISSERLKSA KDVVKVGDVL KVKVSEIDDQ GRIKVSLKDV PENVEAKNKF 700
    LFE 703
    Length:703
    Mass (Da):78,162
    Last modified:July 1, 2008 - v1
    Checksum:i5B41D20BA4D86FB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001080 Genomic DNA. Translation: ACD66423.1.
    RefSeqiWP_012459500.1. NC_010730.1.
    YP_001930977.1. NC_010730.1.

    Genome annotation databases

    EnsemblBacteriaiACD66423; ACD66423; SYO3AOP1_0790.
    GeneIDi6332685.
    KEGGisul:SYO3AOP1_0790.
    PATRICi23766357. VBISulSp94719_0816.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001080 Genomic DNA. Translation: ACD66423.1 .
    RefSeqi WP_012459500.1. NC_010730.1.
    YP_001930977.1. NC_010730.1.

    3D structure databases

    ProteinModelPortali B2V900.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 436114.SYO3AOP1_0790.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD66423 ; ACD66423 ; SYO3AOP1_0790 .
    GeneIDi 6332685.
    KEGGi sul:SYO3AOP1_0790.
    PATRICi 23766357. VBISulSp94719_0816.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218327.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci SSP436114:GI6I-827-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YO3AOP1.

    Entry informationi

    Entry nameiPNP_SULSY
    AccessioniPrimary (citable) accession number: B2V900
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3