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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Sulfurihydrogenibium sp. (strain YO3AOP1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi484MagnesiumUniRule annotation1
Metal bindingi490MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:SYO3AOP1_0790
OrganismiSulfurihydrogenibium sp. (strain YO3AOP1)
Taxonomic identifieri436114 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
Proteomesi
  • UP000001201 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001857581 – 703Polyribonucleotide nucleotidyltransferaseAdd BLAST703

Proteomic databases

PRIDEiB2V900.

Interactioni

Protein-protein interaction databases

STRINGi436114.SYO3AOP1_0790.

Structurei

3D structure databases

ProteinModelPortaliB2V900.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini551 – 610KHUniRule annotationAdd BLAST60
Domaini620 – 688S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218327.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2V900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEIKIETVV NGAPYSIETG YFAKQANGAV IVRQGDTAVL VAAVMSEEPQ
60 70 80 90 100
ADIDFLPLTV EYREKYYAYG KIPGGFVKRE GKPSEREILV ARNIDRPIRP
110 120 130 140 150
LFPKGFYNDV IITAYTLSAD DQYDPDVLGI VGASAALHIS DIPFEGPIAG
160 170 180 190 200
VRVCRVDGQF IVNPTYQQKA KSDLEIVVAG SKDAIVMVEG GAKEVPEEVI
210 220 230 240 250
LEAMLFGHQE IKKLIELQEE LRAKYGKEKI EIPIDEEEIL LKEKFKELAY
260 270 280 290 300
VRIKEAFNIS DKKERNKQIN AIFEEIKTTL EIPEEKVKKA SFVYKDVVSN
310 320 330 340 350
VMRDLVLYEN IRIDGRKPEE IRPIWIKVGV FPRNHGSAIF TRGQTQAFVT
360 370 380 390 400
VTLGSPSEGQ IEESIEAGET LKRFMLHYNF PPFSTGEAKP PRPVSRREIG
410 420 430 440 450
HGNLAERALE PLIPSEEEFP YVIRVVSDIL ESNGSTSMAT VCGGSLALFD
460 470 480 490 500
AGVPMKKHVA GIAMGLIKSE DKFVVLSDIL GDEDHLGDMD FKVAGTRDGV
510 520 530 540 550
TSIQMDIKVK GLTREILQKA LEQAREGRNY ILDLMYQAIP EPRKELSPYA
560 570 580 590 600
PTVTTLRVLP EKISVIIGPA GKNIKKIIEE TGVKIDLDPT GLVKIYATSK
610 620 630 640 650
IAAEKAIDMI NQLIMDIELG EVYLGKVTRV EDYGAFVELM PGKLSLLHVS
660 670 680 690 700
QISSERLKSA KDVVKVGDVL KVKVSEIDDQ GRIKVSLKDV PENVEAKNKF

LFE
Length:703
Mass (Da):78,162
Last modified:July 1, 2008 - v1
Checksum:i5B41D20BA4D86FB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001080 Genomic DNA. Translation: ACD66423.1.
RefSeqiWP_012459500.1. NC_010730.1.

Genome annotation databases

EnsemblBacteriaiACD66423; ACD66423; SYO3AOP1_0790.
KEGGisul:SYO3AOP1_0790.
PATRICi23766357. VBISulSp94719_0816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001080 Genomic DNA. Translation: ACD66423.1.
RefSeqiWP_012459500.1. NC_010730.1.

3D structure databases

ProteinModelPortaliB2V900.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi436114.SYO3AOP1_0790.

Proteomic databases

PRIDEiB2V900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD66423; ACD66423; SYO3AOP1_0790.
KEGGisul:SYO3AOP1_0790.
PATRICi23766357. VBISulSp94719_0816.

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218327.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPNP_SULSY
AccessioniPrimary (citable) accession number: B2V900
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 1, 2008
Last modified: November 2, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.