B2V8P5 (NTPA_SULSY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-canonical purine NTP pyrophosphatase
EC=3.6.1.19

Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name=NTPase

Gene names

Ordered Locus Names:

SYO3AOP1_0682

Organism

Sulfurihydrogenibium sp. (strain YO3AOP1) [Complete proteome] [HAMAP]

Taxonomic identifier

436114 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Hydrogenothermaceae › Sulfurihydrogenibium

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405
Cofactor	Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.
Subunit structure	Homodimer By similarity. HAMAP MF_01405
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro nucleoside-triphosphate diphosphatase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Non-canonical purine NTP pyrophosphatase HAMAP MF_01405		PRO_1000145499
Regions
	Region	7 – 12	6	Substrate binding By similarity
	Region	69 – 70	2	Substrate binding By similarity
Sites
	Metal binding	40	1	Magnesium or manganese By similarity
	Metal binding	69	1	Magnesium or manganese By similarity
	Binding site	165	1	Substrate By similarity
	Binding site	185	1	Substrate By similarity
	Binding site	191	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2V8P5 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: B728C5FDC1596440	FASTA	206	23,614
	10 20 30 40 50 60 MKILLATTNE GKVRELRQLL KDLDIEILSL KDMDKKLEVE EDKETFLENA IKKATSYAKF 70 80 90 100 110 120 YKLPVIAEDS GLEVDALNGL PGIYSARFFD IEFGKEVLKE IPENLSKDEK NNLKLLRLLE 130 140 150 160 170 180 NQTNRKARYK TALVFYNFDY GIWTEGVCEG QIAYKPEGNQ GFGYDPIFIP EGYNKTMAQL 190 200 TPEEKNKISH RGKAVSKLVE ILKKVL

References

[1]

"Complete and draft genome sequences of six members of the Aquificales." Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A. J. Bacteriol. 191:1992-1993(2009) [PubMed: 19136599] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YO3AOP1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001080 Genomic DNA. Translation: ACD66318.1.
RefSeq	YP_001930872.1. NC_010730.1.
3D structure databases
ProteinModelPortal	B2V8P5.
ModBase	Search...
Protein-protein interaction databases
STRING	B2V8P5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6331961.
GenomeReviews	Gene locus SYO3AOP1_0682 in contig CP001080_GR.
KEGG	sul:SYO3AOP1_0682.
PATRIC	23766111. VBISulSp94719_0703.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG697237.
OMA	GVYTADW.
ProtClustDB	PRK14824.
Family and domain databases
HAMAP	MF_01405. Non_canon_purine_NTPase. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
KO	K02428.
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. TIGR00042. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_SULSY

Accession

Primary (citable) accession number: B2V8P5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program