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B2V8L5 (B2V8L5_SULSY) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
EC=2.2.1.7 HAMAP MF_00315
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase HAMAP MF_00315
Gene names
Name:dxs HAMAP MF_00315
Ordered Locus Names:SYO3AOP1_0652
OrganismSulfurihydrogenibium sp. (strain YO3AOP1) [Complete proteome] [HAMAP]
Taxonomic identifier436114 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Hydrogenothermaceae › Sulfurihydrogenibium

Protein attributes

Sequence length631 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315 SAAS SAAS001017

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315 SAAS SAAS001017

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP MF_00315 SAAS SAAS001017

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315 SAAS SAAS001017

Subunit structure

Homodimer By similarity. HAMAP MF_00315 SAAS SAAS001017

Sequence similarities

Belongs to the transketolase family. DXPS subfamily. HAMAP MF_00315

Sequences

Sequence LengthMass (Da)Tools
B2V8L5 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 2BE09019C8C565CD

FASTA63170,563
        10         20         30         40         50         60 
MKDYPMLEKI NNYKDLKNLN KEEIEKLCED IRSYIIDVTS LNGGHIGPSL GTVELTVALL 

        70         80         90        100        110        120 
MAFDPEKDKI VWDVGHQTYA YKILTDRKEQ FRTLRQYKGI SGFSKIKESK YDHFGTGHSS 

       130        140        150        160        170        180 
TSISAALGFR VGKDLKKDDV YTIAVIGDGA MTAGQAFEGL NNAGWLDPSR FIVILNDNQM 

       190        200        210        220        230        240 
SISPNVGAIY TYFNKIITKQ VFQKPRQKLK EAINKIFGEQ GVKIFRKIEE YTKGLFAPGL 

       250        260        270        280        290        300 
IFEELGFTYV GPIDGHSLFD LEQTLENIKQ MRGPILLHVI TQKGKGYKYA EENPTTFHGV 

       310        320        330        340        350        360 
SPFDKISGVF NKSSNLPTYS KVFGDALVEL AEKDDKIVAI TPAMKEGSGL VKFAEKFPDR 

       370        380        390        400        410        420 
FFDVGIAEQH AATFAGALAL EGFKPVAAYY STFLQRAYDQ VIHDIALQEL PVFFAIDRGG 

       430        440        450        460        470        480 
LVGDDGPTHH GVFDIAFLRP IPNMIIASPK DEQELRDLLY IGLNSKRPFA LRYPRGTGYG 

       490        500        510        520        530        540 
VKIEGFNTIE IGSWEILDEG RDIAILAVGK YVYRALEVKK QLRLKGFNPT VVNARFIKPM 

       550        560        570        580        590        600 
DENLLNKLLK THEFVITAED GVLNGGFGSA VAEFVIDNGY SNKVLRFGIP DKFIEHGKVE 

       610        620        630 
LLERDLGLDV NSMVNKIEEF LKVKKAVLNT A

« Hide

References

[1]"Complete and draft genome sequences of six members of the Aquificales."
Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.
J. Bacteriol. 191:1992-1993(2009) [PubMed: 19136599] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001080 Genomic DNA. Translation: ACD66288.1.
RefSeqYP_001930842.1. NC_010730.1.

3D structure databases

ProteinModelPortalB2V8L5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2V8L5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6331121.
GenomeReviewsGene locus SYO3AOP1_0652 in contig CP001080_GR.
KEGGsul:SYO3AOP1_0652.
PATRIC23766045. VBISulSp94719_0673.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG571647.
OMADPILYHG.
ProtClustDBPRK05444.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR001017. DH_E1.
IPR005477. Dxylulose-5-P_synthase.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB2V8L5_SULSY
AccessionPrimary (citable) accession number: B2V8L5
Entry history
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info