B2V845 (B2V845_SULSY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Ordered Locus Names:

SYO3AOP1_0477

Organism

Sulfurihydrogenibium sp. (strain YO3AOP1) [Complete proteome] [HAMAP]

Taxonomic identifier

436114 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Hydrogenothermaceae › Sulfurihydrogenibium

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862 EMBL ACD66118.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2V845 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 1F4DE78A5F15323A	FASTA	291	33,135
	10 20 30 40 50 60 MKIIDKLKNT KVSISFEFFP PKTEEAEKTL FETISNLQPL NPTFVSVTYG AGGSTREKTR 70 80 90 100 110 120 DIVKKIHEET KLTVMAHLTC IGHSKQEILS ILDDYEKIGI ENILALRGDI PLNFEKSDIL 130 140 150 160 170 180 SDGCKHASEL VSLIRETYKD YFCIAVASYP EGHPESPNLE REILYFKKKV EVGADFSITQ 190 200 210 220 230 240 MFFDNSYFYE FLEKCEIAGI NIPIIPGIMP ITNFNQIKKF ASLCGATIPE EVVQKFEKYA 250 260 270 280 290 DNPEETKKIG IEFATLQCMD LIKHGVKGLH FYTLNKSDAT IKIYENIKDY L

References

[1]

"Complete and draft genome sequences of six members of the Aquificales." Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A. J. Bacteriol. 191:1992-1993(2009) [PubMed: 19136599] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001080 Genomic DNA. Translation: ACD66118.1.
RefSeq	YP_001930672.1. NC_010730.1.
3D structure databases
ProteinModelPortal	B2V845.
ModBase	Search...
Protein-protein interaction databases
STRING	B2V845.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6331483.
GenomeReviews	Gene locus SYO3AOP1_0477 in contig CP001080_GR.
KEGG	sul:SYO3AOP1_0477.
PATRIC	23765679. VBISulSp94719_0491.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG649727.
OMA	ITQMFFD.
ProtClustDB	CLSK2299700.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B2V845_SULSY

Accession

Primary (citable) accession number: B2V845

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)