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B2V7R0

- B2V7R0_SULSY

UniProt

B2V7R0 - B2V7R0_SULSY

Protein

3-isopropylmalate dehydratase small subunit

Gene

leuD

Organism
Sulfurihydrogenibium sp. (strain YO3AOP1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.UniRule annotation

    Catalytic activityi

    (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 3-isopropylmalate dehydratase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LyaseUniRule annotation

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisUniRule annotation

    Enzyme and pathway databases

    BioCyciSSP436114:GI6I-354-MONOMER.
    UniPathwayiUPA00048; UER00071.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-isopropylmalate dehydratase small subunitUniRule annotation (EC:4.2.1.33UniRule annotation)
    Alternative name(s):
    Alpha-IPM isomeraseUniRule annotation
    Isopropylmalate isomeraseUniRule annotation
    Gene namesi
    Name:leuDUniRule annotation
    Ordered Locus Names:SYO3AOP1_0338Imported
    OrganismiSulfurihydrogenibium sp. (strain YO3AOP1)Imported
    Taxonomic identifieri436114 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
    ProteomesiUP000001201: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. 3-isopropylmalate dehydratase complex Source: InterPro

    Interactioni

    Subunit structurei

    Heterodimer of LeuC and LeuD.UniRule annotation

    Protein-protein interaction databases

    STRINGi436114.SYO3AOP1_0338.

    Structurei

    3D structure databases

    ProteinModelPortaliB2V7R0.
    SMRiB2V7R0. Positions 1-161.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LeuD family. LeuD type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0066.
    HOGENOMiHOG000222940.
    KOiK01704.
    OMAiYCMEDAR.
    OrthoDBiEOG6PZXB8.

    Family and domain databases

    Gene3Di3.20.19.10. 1 hit.
    HAMAPiMF_01032. LeuD_type2.
    InterProiIPR015937. Acoase/IPM_deHydtase.
    IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
    IPR011827. IsopropMal_deHydtase_ssu.
    IPR011824. IsopropMal_deHydtase_ssu_bac.
    [Graphical view]
    PANTHERiPTHR11670. PTHR11670. 1 hit.
    PfamiPF00694. Aconitase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52016. SSF52016. 1 hit.
    TIGRFAMsiTIGR02084. leud. 1 hit.
    TIGR02087. LEUD_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2V7R0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIRGRVWKFK DDVDTDQIIP ARYLVTTDPK ELAKHVMEDA DPTFPSKVKE    50
    GDILVAGKNF GCGSSREHAP LAIKGAGIAA VVAESFARIF FRNAINLGLL 100
    IIESPEAARE AEEGDILEID INQGVIRNVT KNKEYKIKPL PENLQAILKA 150
    GGLMEYAKEK IKNAS 165
    Length:165
    Mass (Da):18,146
    Last modified:July 1, 2008 - v1
    Checksum:i345698F080CC802A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001080 Genomic DNA. Translation: ACD65983.1.
    RefSeqiYP_001930537.1. NC_010730.1.

    Genome annotation databases

    EnsemblBacteriaiACD65983; ACD65983; SYO3AOP1_0338.
    GeneIDi6332711.
    KEGGisul:SYO3AOP1_0338.
    PATRICi23765383. VBISulSp94719_0350.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001080 Genomic DNA. Translation: ACD65983.1 .
    RefSeqi YP_001930537.1. NC_010730.1.

    3D structure databases

    ProteinModelPortali B2V7R0.
    SMRi B2V7R0. Positions 1-161.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 436114.SYO3AOP1_0338.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD65983 ; ACD65983 ; SYO3AOP1_0338 .
    GeneIDi 6332711.
    KEGGi sul:SYO3AOP1_0338.
    PATRICi 23765383. VBISulSp94719_0350.

    Phylogenomic databases

    eggNOGi COG0066.
    HOGENOMi HOG000222940.
    KOi K01704.
    OMAi YCMEDAR.
    OrthoDBi EOG6PZXB8.

    Enzyme and pathway databases

    UniPathwayi UPA00048 ; UER00071 .
    BioCyci SSP436114:GI6I-354-MONOMER.

    Family and domain databases

    Gene3Di 3.20.19.10. 1 hit.
    HAMAPi MF_01032. LeuD_type2.
    InterProi IPR015937. Acoase/IPM_deHydtase.
    IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
    IPR011827. IsopropMal_deHydtase_ssu.
    IPR011824. IsopropMal_deHydtase_ssu_bac.
    [Graphical view ]
    PANTHERi PTHR11670. PTHR11670. 1 hit.
    Pfami PF00694. Aconitase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52016. SSF52016. 1 hit.
    TIGRFAMsi TIGR02084. leud. 1 hit.
    TIGR02087. LEUD_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YO3AOP1Imported.

    Entry informationi

    Entry nameiB2V7R0_SULSY
    AccessioniPrimary (citable) accession number: B2V7R0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3