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Protein

3-isopropylmalate dehydratase small subunit

Gene

leuD

Organism
Sulfurihydrogenibium sp. (strain YO3AOP1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.UniRule annotation

Catalytic activityi

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.UniRule annotation

Pathway:iL-leucine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. 2-isopropylmalate synthase (leuA)
  2. 3-isopropylmalate dehydratase small subunit (leuD), 3-isopropylmalate dehydratase large subunit (leuC)
  3. 3-isopropylmalate dehydrogenase (leuB)
  4. no protein annotated in this organism
This subpathway is part of the pathway L-leucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate, the pathway L-leucine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciSSP436114:GI6I-354-MONOMER.
UniPathwayiUPA00048; UER00071.

Names & Taxonomyi

Protein namesi
Recommended name:
3-isopropylmalate dehydratase small subunitUniRule annotation (EC:4.2.1.33UniRule annotation)
Alternative name(s):
Alpha-IPM isomeraseUniRule annotation
Isopropylmalate isomeraseUniRule annotation
Gene namesi
Name:leuDUniRule annotation
Ordered Locus Names:SYO3AOP1_0338Imported
OrganismiSulfurihydrogenibium sp. (strain YO3AOP1)Imported
Taxonomic identifieri436114 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
ProteomesiUP000001201 Componenti: Chromosome

Interactioni

Subunit structurei

Heterodimer of LeuC and LeuD.UniRule annotation

Protein-protein interaction databases

STRINGi436114.SYO3AOP1_0338.

Structurei

3D structure databases

ProteinModelPortaliB2V7R0.
SMRiB2V7R0. Positions 1-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LeuD family. LeuD type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0066.
HOGENOMiHOG000222940.
KOiK01704.
OMAiEYRIRPY.
OrthoDBiEOG6PZXB8.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
HAMAPiMF_01032. LeuD_type2.
InterProiIPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR011824. LeuD/DmdB_bac.
IPR011827. LeuD_type2/HacB/DmdB.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00694. Aconitase_C. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR02084. leud. 1 hit.
TIGR02087. LEUD_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

B2V7R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRGRVWKFK DDVDTDQIIP ARYLVTTDPK ELAKHVMEDA DPTFPSKVKE
60 70 80 90 100
GDILVAGKNF GCGSSREHAP LAIKGAGIAA VVAESFARIF FRNAINLGLL
110 120 130 140 150
IIESPEAARE AEEGDILEID INQGVIRNVT KNKEYKIKPL PENLQAILKA
160
GGLMEYAKEK IKNAS
Length:165
Mass (Da):18,146
Last modified:July 1, 2008 - v1
Checksum:i345698F080CC802A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001080 Genomic DNA. Translation: ACD65983.1.
RefSeqiWP_007547897.1. NC_010730.1.

Genome annotation databases

EnsemblBacteriaiACD65983; ACD65983; SYO3AOP1_0338.
KEGGisul:SYO3AOP1_0338.
PATRICi23765383. VBISulSp94719_0350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001080 Genomic DNA. Translation: ACD65983.1.
RefSeqiWP_007547897.1. NC_010730.1.

3D structure databases

ProteinModelPortaliB2V7R0.
SMRiB2V7R0. Positions 1-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi436114.SYO3AOP1_0338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD65983; ACD65983; SYO3AOP1_0338.
KEGGisul:SYO3AOP1_0338.
PATRICi23765383. VBISulSp94719_0350.

Phylogenomic databases

eggNOGiCOG0066.
HOGENOMiHOG000222940.
KOiK01704.
OMAiEYRIRPY.
OrthoDBiEOG6PZXB8.

Enzyme and pathway databases

UniPathwayiUPA00048; UER00071.
BioCyciSSP436114:GI6I-354-MONOMER.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
HAMAPiMF_01032. LeuD_type2.
InterProiIPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR011824. LeuD/DmdB_bac.
IPR011827. LeuD_type2/HacB/DmdB.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00694. Aconitase_C. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR02084. leud. 1 hit.
TIGR02087. LEUD_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YO3AOP1Imported.

Entry informationi

Entry nameiB2V7R0_SULSY
AccessioniPrimary (citable) accession number: B2V7R0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 22, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.