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B2V7R0

- B2V7R0_SULSY

UniProt

B2V7R0 - B2V7R0_SULSY

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Protein

3-isopropylmalate dehydratase small subunit

Gene

leuD

Organism
Sulfurihydrogenibium sp. (strain YO3AOP1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.UniRule annotation

Catalytic activityi

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 3-isopropylmalate dehydratase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciSSP436114:GI6I-354-MONOMER.
UniPathwayiUPA00048; UER00071.

Names & Taxonomyi

Protein namesi
Recommended name:
3-isopropylmalate dehydratase small subunitUniRule annotation (EC:4.2.1.33UniRule annotation)
Alternative name(s):
Alpha-IPM isomeraseUniRule annotation
Isopropylmalate isomeraseUniRule annotation
Gene namesi
Name:leuDUniRule annotation
Ordered Locus Names:SYO3AOP1_0338Imported
OrganismiSulfurihydrogenibium sp. (strain YO3AOP1)Imported
Taxonomic identifieri436114 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
ProteomesiUP000001201: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. 3-isopropylmalate dehydratase complex Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Heterodimer of LeuC and LeuD.UniRule annotation

Protein-protein interaction databases

STRINGi436114.SYO3AOP1_0338.

Structurei

3D structure databases

ProteinModelPortaliB2V7R0.
SMRiB2V7R0. Positions 1-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LeuD family. LeuD type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0066.
HOGENOMiHOG000222940.
KOiK01704.
OMAiYCMEDAR.
OrthoDBiEOG6PZXB8.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
HAMAPiMF_01032. LeuD_type2.
InterProiIPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR011827. IsopropMal_deHydtase_ssu.
IPR011824. IsopropMal_deHydtase_ssu_bac.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00694. Aconitase_C. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR02084. leud. 1 hit.
TIGR02087. LEUD_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

B2V7R0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIRGRVWKFK DDVDTDQIIP ARYLVTTDPK ELAKHVMEDA DPTFPSKVKE
60 70 80 90 100
GDILVAGKNF GCGSSREHAP LAIKGAGIAA VVAESFARIF FRNAINLGLL
110 120 130 140 150
IIESPEAARE AEEGDILEID INQGVIRNVT KNKEYKIKPL PENLQAILKA
160
GGLMEYAKEK IKNAS
Length:165
Mass (Da):18,146
Last modified:July 1, 2008 - v1
Checksum:i345698F080CC802A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001080 Genomic DNA. Translation: ACD65983.1.
RefSeqiYP_001930537.1. NC_010730.1.

Genome annotation databases

EnsemblBacteriaiACD65983; ACD65983; SYO3AOP1_0338.
GeneIDi6332711.
KEGGisul:SYO3AOP1_0338.
PATRICi23765383. VBISulSp94719_0350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001080 Genomic DNA. Translation: ACD65983.1 .
RefSeqi YP_001930537.1. NC_010730.1.

3D structure databases

ProteinModelPortali B2V7R0.
SMRi B2V7R0. Positions 1-161.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436114.SYO3AOP1_0338.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD65983 ; ACD65983 ; SYO3AOP1_0338 .
GeneIDi 6332711.
KEGGi sul:SYO3AOP1_0338.
PATRICi 23765383. VBISulSp94719_0350.

Phylogenomic databases

eggNOGi COG0066.
HOGENOMi HOG000222940.
KOi K01704.
OMAi YCMEDAR.
OrthoDBi EOG6PZXB8.

Enzyme and pathway databases

UniPathwayi UPA00048 ; UER00071 .
BioCyci SSP436114:GI6I-354-MONOMER.

Family and domain databases

Gene3Di 3.20.19.10. 1 hit.
HAMAPi MF_01032. LeuD_type2.
InterProi IPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR011827. IsopropMal_deHydtase_ssu.
IPR011824. IsopropMal_deHydtase_ssu_bac.
[Graphical view ]
PANTHERi PTHR11670. PTHR11670. 1 hit.
Pfami PF00694. Aconitase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52016. SSF52016. 1 hit.
TIGRFAMsi TIGR02084. leud. 1 hit.
TIGR02087. LEUD_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YO3AOP1Imported.

Entry informationi

Entry nameiB2V7R0_SULSY
AccessioniPrimary (citable) accession number: B2V7R0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 1, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3