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B2V790

- PYRF_SULSY

UniProt

B2V790 - PYRF_SULSY

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Sulfurihydrogenibium sp. (strain YO3AOP1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei9 – 91SubstrateUniRule annotation
    Binding sitei30 – 301SubstrateUniRule annotation
    Active sitei59 – 591Proton donorUniRule annotation
    Binding sitei114 – 1141SubstrateUniRule annotation
    Binding sitei175 – 1751SubstrateUniRule annotation
    Binding sitei184 – 1841SubstrateUniRule annotation
    Binding sitei204 – 2041Substrate; via amide nitrogenUniRule annotation
    Binding sitei205 – 2051SubstrateUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciSSP436114:GI6I-1775-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:SYO3AOP1_1724
    OrganismiSulfurihydrogenibium sp. (strain YO3AOP1)
    Taxonomic identifieri436114 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
    ProteomesiUP000001201: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Orotidine 5'-phosphate decarboxylasePRO_1000138566Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi436114.SYO3AOP1_1724.

    Structurei

    3D structure databases

    ProteinModelPortaliB2V790.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni57 – 6610Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000226071.
    KOiK01591.
    OMAiRPITQSA.
    OrthoDBiEOG6N6815.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01200_B. OMPdecase_type1_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2V790-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKLALALDV NDINQALEIV DEIQDKIIIK IGYNLFIKGG INFVKQIKDR    50
    GFDIFLDLKL HDIPNTVYNG VKAVSEIGVN YLTIHSLGGQ EMIQQAVKAK 100
    EGTDLKILAV TILTSHDENY PKLLGSSLSV PDLAYRLADM AVSNGSDGIV 150
    CSSHEVKFLK EHIQKPFIAV VPGIRLTKEK TDDQTRIATP EEALRDGADI 200
    IVVGRPILKA EDRNKIIKEM LSVIEEL 227
    Length:227
    Mass (Da):25,128
    Last modified:July 1, 2008 - v1
    Checksum:iECC29E443DB45C51
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001080 Genomic DNA. Translation: ACD67321.1.
    RefSeqiWP_012460376.1. NC_010730.1.
    YP_001931875.1. NC_010730.1.

    Genome annotation databases

    EnsemblBacteriaiACD67321; ACD67321; SYO3AOP1_1724.
    GeneIDi6331471.
    KEGGisul:SYO3AOP1_1724.
    PATRICi23768331. VBISulSp94719_1788.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001080 Genomic DNA. Translation: ACD67321.1 .
    RefSeqi WP_012460376.1. NC_010730.1.
    YP_001931875.1. NC_010730.1.

    3D structure databases

    ProteinModelPortali B2V790.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 436114.SYO3AOP1_1724.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD67321 ; ACD67321 ; SYO3AOP1_1724 .
    GeneIDi 6331471.
    KEGGi sul:SYO3AOP1_1724.
    PATRICi 23768331. VBISulSp94719_1788.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000226071.
    KOi K01591.
    OMAi RPITQSA.
    OrthoDBi EOG6N6815.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci SSP436114:GI6I-1775-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01200_B. OMPdecase_type1_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YO3AOP1.

    Entry informationi

    Entry nameiPYRF_SULSY
    AccessioniPrimary (citable) accession number: B2V790
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3