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B2V704

- LPXB_SULSY

UniProt

B2V704 - LPXB_SULSY

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Sulfurihydrogenibium sp. (strain YO3AOP1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSSP436114:GI6I-147-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:SYO3AOP1_0140
OrganismiSulfurihydrogenibium sp. (strain YO3AOP1)
Taxonomic identifieri436114 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaeSulfurihydrogenibium
ProteomesiUP000001201: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Lipid-A-disaccharide synthasePRO_1000123067Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi436114.SYO3AOP1_0140.

Structurei

3D structure databases

ProteinModelPortaliB2V704.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B2V704-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKIFLSVGE ISGDNYASEL AKHLKEYQIT GITGPKMRAI GVKPVANLED
60 70 80 90 100
ISVVGLTEAL SKYKKIKEVF KQSVQALKSG VDLLIVVDFP GFNIKLLKEA
110 120 130 140 150
KKLGIKTVYF ISPQVWAWGS GRVKEIVENT DLLISILPFE EEIYKPYVSD
160 170 180 190 200
KFKFAYVGHP LLDIIKIYEN EDSFKQKLNI PKNKRIIGLL AGSRESEVNV
210 220 230 240 250
ILPILIEAAR LLTKTFDDLH FVIPATVNMV DRVLEKVNFS LPITVITSNL
260 270 280 290 300
SDKNLPKFEN PSYEVMKNAV FSIITSGTAT LEAAIIGNPF IIVYKVSPIT
310 320 330 340 350
YFIGKKLVKI NYLGLPNIIA GNEIVPELLQ DRCNPLDIAN KTLEFLTDKN
360 370 380
LYKTQKRNLE IVRKSLGKKG AIERASNLIR TLLEKGQA
Length:388
Mass (Da):43,452
Last modified:July 1, 2008 - v1
Checksum:i1976F1C53872FAD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001080 Genomic DNA. Translation: ACD65786.1.
RefSeqiWP_012458876.1. NC_010730.1.
YP_001930340.1. NC_010730.1.

Genome annotation databases

EnsemblBacteriaiACD65786; ACD65786; SYO3AOP1_0140.
GeneIDi6331338.
KEGGisul:SYO3AOP1_0140.
PATRICi23764965. VBISulSp94719_0149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001080 Genomic DNA. Translation: ACD65786.1 .
RefSeqi WP_012458876.1. NC_010730.1.
YP_001930340.1. NC_010730.1.

3D structure databases

ProteinModelPortali B2V704.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436114.SYO3AOP1_0140.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACD65786 ; ACD65786 ; SYO3AOP1_0140 .
GeneIDi 6331338.
KEGGi sul:SYO3AOP1_0140.
PATRICi 23764965. VBISulSp94719_0149.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci SSP436114:GI6I-147-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YO3AOP1.

Entry informationi

Entry nameiLPXB_SULSY
AccessioniPrimary (citable) accession number: B2V704
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3