B2V704 (LPXB_SULSY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	SYO3AOP1_0140

Organism

Sulfurihydrogenibium sp. (strain YO3AOP1) [Complete proteome] [HAMAP]

Taxonomic identifier

436114 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Aquificae › Aquificae › Aquificales › Hydrogenothermaceae › Sulfurihydrogenibium

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392		PRO_1000123067

Sequences

	Sequence		Length	Mass (Da)
	B2V704 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 1976F1C53872FAD3	FASTA	388	43,452
	10 20 30 40 50 60 MKKIFLSVGE ISGDNYASEL AKHLKEYQIT GITGPKMRAI GVKPVANLED ISVVGLTEAL 70 80 90 100 110 120 SKYKKIKEVF KQSVQALKSG VDLLIVVDFP GFNIKLLKEA KKLGIKTVYF ISPQVWAWGS 130 140 150 160 170 180 GRVKEIVENT DLLISILPFE EEIYKPYVSD KFKFAYVGHP LLDIIKIYEN EDSFKQKLNI 190 200 210 220 230 240 PKNKRIIGLL AGSRESEVNV ILPILIEAAR LLTKTFDDLH FVIPATVNMV DRVLEKVNFS 250 260 270 280 290 300 LPITVITSNL SDKNLPKFEN PSYEVMKNAV FSIITSGTAT LEAAIIGNPF IIVYKVSPIT 310 320 330 340 350 360 YFIGKKLVKI NYLGLPNIIA GNEIVPELLQ DRCNPLDIAN KTLEFLTDKN LYKTQKRNLE 370 380 IVRKSLGKKG AIERASNLIR TLLEKGQA

References

[1]

"Complete and draft genome sequences of six members of the Aquificales." Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A. J. Bacteriol. 191:1992-1993(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YO3AOP1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001080 Genomic DNA. Translation: ACD65786.1.
RefSeq	YP_001930340.1. NC_010730.1.
3D structure databases
ProteinModelPortal	B2V704.
ModBase	Search...
Protein-protein interaction databases
STRING	436114.SYO3AOP1_0140.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACD65786; ACD65786; SYO3AOP1_0140.
GeneID	6331338.
KEGG	sul:SYO3AOP1_0140.
PATRIC	23764965. VBISulSp94719_0149.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HOG000018004.
KO	K00748.
OMA	IARMLVN.
ProtClustDB	CLSK2479322.
Enzyme and pathway databases
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB.
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. lpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_SULSY

Accession

Primary (citable) accession number: B2V704

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 1, 2008
Last modified:	May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program