B2V6Y1 (B2V6Y1_SULSY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP MF_00388
EC=3.5.1.- HAMAP MF_00388

Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase HAMAP MF_00388

Gene names

Name:	lpxC HAMAP MF_00388
Ordered Locus Names:	SYO3AOP1_1715

Organism

Sulfurihydrogenibium sp. (strain YO3AOP1) [Complete proteome] [HAMAP]

Taxonomic identifier

436114 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Hydrogenothermaceae › Sulfurihydrogenibium

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00388 SAAS SAAS015870
Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP MF_00388 SAAS SAAS015870
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP MF_00388 SAAS SAAS015870
Sequence similarities	Belongs to the LpxC family. HAMAP MF_00388

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00388 SAAS SAAS015870 Lipid synthesis
Molecular function	Hydrolase HAMAP MF_00388 SAAS SAAS015870
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2V6Y1 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 8C64289D74C86CFE	FASTA	297	33,685
	10 20 30 40 50 60 MICQFQRTIK KPIIIEGIGL HSGDNVKIKL FPANKNEGIN FIKNNVVIPA KIDYAHSFEY 70 80 90 100 110 120 STTLYKDGVS VRTIEHLMAA LYFTGIDNVY IELIGEELPI LDGSSKGFVE RIKEAGIKTL 130 140 150 160 170 180 NEEKLYAVLE EPVKVEIEDK FIMAKPSNEI KITYQANYNN DIIGNKSFTY IPYEKESYEG 190 200 210 220 230 240 VYTARTYCFL EEVEYLKKNG LAKGGSLENA VVFHNNQVIN EEGLRFEDEP VRHKVLDLIG 250 260 270 280 290 DLYLLGYPLV AEVYSFKGGH RLNAMFVKTL VENSLFTIKP ASEVLNFIPN YKEALVG

References

[1]

"Complete and draft genome sequences of six members of the Aquificales." Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S., Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A., Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A. J. Bacteriol. 191:1992-1993(2009) [PubMed: 19136599] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001080 Genomic DNA. Translation: ACD67313.1.
RefSeq	YP_001931867.1. NC_010730.1.
3D structure databases
ProteinModelPortal	B2V6Y1.
ModBase	Search...
Protein-protein interaction databases
STRING	B2V6Y1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6331439.
GenomeReviews	Gene locus SYO3AOP1_1715 in contig CP001080_GR.
KEGG	sul:SYO3AOP1_1715.
PATRIC	23768311. VBISulSp94719_1778.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG482342.
OMA	KAYKSGH.
ProtClustDB	PRK13186.
Family and domain databases
HAMAP	MF_00388. LpxC. [Tree]
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR004463. UDP-acyl_GlcNac_deAcase. IPR011334. UDP-acyl_GlcNac_deAcase_C. IPR015870. UDP-acyl_N-AcGlcN_deAcase_N. [Graphical view]
Gene3D	G3DSA:3.30.1700.10. UDP-acyl_N-AcGlcN_deAcase_C. 1 hit. G3DSA:3.30.230.20. UDP-acyl_N-AcGlcN_deAcase_N. 1 hit.
KO	K02535.
Pfam	PF03331. LpxC. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMs	TIGR00325. LpxC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B2V6Y1_SULSY

Accession

Primary (citable) accession number: B2V6Y1

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)